Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity

Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi

(2014) María V. Díaz et al.   ACTA TROPICA

Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice

(2014) José A. Jara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: A new therapeutic target?

(2014) V. Jimenez et al.   PHYTOMEDICINE

Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway

(2014) Lijun Huang et al.   PLoS One

The Effect of (-)-Epigallocatechin 3-O - Gallate In Vitro and In Vivo in Leishmania braziliensis: Involvement of Reactive Oxygen Species as a Mechanism of Action

(2014) Job D. F. Inacio et al.   PLoS Neglected Tropical Diseases

Benznidazole prevents endothelial damage in an experimental model of Chagas disease

(2013) Alfredo Molina-Berríos et al.   ACTA TROPICA

Mitochondria as a pharmacological target: Magnum overview

(2013) Anna Olszewska et al.   IUBMB LIFE

Maxima in Antioxidant Distributions and Efficiencies with Increasing Hydrophobicity of Gallic Acid and Its Alkyl Esters. The Pseudophase Model Interpretation of the “Cutoff Effect”

(2013) Sonia Losada Barreiro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK a: implications for the design of mitochondrial probes and therapies

(2012) Peter G. Finichiu et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Synthesis and Structure–Activity Analysis of New Phosphonium Salts with Potent Activity against African Trypanosomes

(2012) Andrea Taladriz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trypanocidal Action of (−)-Elatol Involves an Oxidative Stress Triggered by Mitochondria Dysfunction

(2012) Vânia Cristina Desoti et al.   Marine Drugs

Chagas Disease: “The New HIV/AIDS of the Americas”

(2012) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Mitochondria-Targeted Small Molecule Therapeutics and Probes

(2011) Robin A.J. Smith et al.   ANTIOXIDANTS & REDOX SIGNALING

The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

(2011) Lisvane Silva Paes et al.   CURRENT PHARMACEUTICAL DESIGN

O2 consumption rates along the growth curve: new insights into Trypanosoma cruzi mitochondrial respiratory chain

(2011) Thiago M. Silva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Antitrypanosomal Therapy for Chronic Chagas' Disease

(2011) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria and Trypanosomatids: Targets and Drugs

(2011) Lianet Monzote Fidalgo et al.   PHARMACEUTICAL RESEARCH

Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

(2010) Mariana Boiani et al.   BIOCHEMICAL PHARMACOLOGY

Symmetrical choline-derived dications display strong anti-kinetoplastid activity

(2010) Hasan M. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

(2010) J. Román Luque-Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

(2010) Despina Smirlis et al.   Parasites & Vectors

In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea

(2010) P. VEIGA-SANTOS et al.   PARASITOLOGY

Chagas disease: A Latin American health problem becoming a world health problem

(2009) Gabriel A. Schmunis et al.   ACTA TROPICA

The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction

(2009) Rubem F.S. Menna-Barreto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genes

(2009) Julio César Carranza et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Different cell death pathways induced by drugs in Trypanosoma cruzi: An ultrastructural study

(2008) Rubem F.S. Menna-Barreto et al.   MICRON