Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor

Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling

(2018) Aurelie Nguyen Dinh Cat et al.   Scientific Reports

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

(2018) Jaime Ibarrola et al.   Scientific Reports

Parkin-mediated mitophagy is downregulated in browning of white adipose tissue

(2017) David Taylor et al.   Obesity

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2

(2017) Gabriel Wagner et al.   Scientific Reports

Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in ObesityHighlights

(2016) Laura J. Den Hartigh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction

(2016) José Pedro Castro et al.   BIOLOGICAL CHEMISTRY

AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity

(2016) Ting Luo et al.   DIABETES

Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase

(2016) Aurelie Nguyen Dinh Cat et al.   DIABETES

PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

(2016) Sun-Sil Choi et al.   DIABETES

Increased Energy Expenditure,Ucp1Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)

(2016) Kevin Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo

(2016) Srinivas Mummidi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet

(2016) Noemí Arias et al.   Obesity

Potential Modulation of Sirtuins by Oxidative Stress

(2016) Leonardo Santos et al.   Oxidative Medicine and Cellular Longevity

Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue

(2016) Umesh D. Wankhade et al.   Biomed Research International

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice

(2016) Michella S. Coelho et al.   PLoS One

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

(2015) Kristin I. Stanford et al.   DIABETES

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 SynthaseNovelty and Significance

(2015) Riccardo Urbanet et al.   HYPERTENSION

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

(2015) S Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

How Effective Are Antioxidant Supplements in Obesity and Diabetes?

(2015) Daniyal Abdali et al.   MEDICAL PRINCIPLES AND PRACTICE

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy in adipose tissue of patients with obesity and type 2 diabetes

(2015) J. Kosacka et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells Both In Vitro and In Vivo

(2014) Nina Queisser et al.   ANTIOXIDANTS & REDOX SIGNALING

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Mitochondrial target of thiazolidinediones

(2014) J. R. Colca et al.   DIABETES OBESITY & METABOLISM

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

(2014) Andrea Armani et al.   FASEB JOURNAL

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

(2014) F. Romana Auciello et al.   FEBS LETTERS

The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes

(2014) M-J Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria

(2014) Jessica Soto Hernández et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cross talk between angiotensin-(1–7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice

(2014) João Marcus Oliveira Andrade et al.   PEPTIDES

Imbalance between Pro and Anti-Oxidant Mechanisms in Perivascular Adipose Tissue Aggravates Long-Term High-Fat Diet-Derived Endothelial Dysfunction

(2014) Marta Gil-Ortega et al.   PLoS One

Effects of aldosterone on insulin sensitivity and secretion

(2014) James M. Luther   STEROIDS

Mineralocorticoid receptor in adipocytes and macrophages: A promising target to fight metabolic syndrome

(2014) Vincenzo Marzolla et al.   STEROIDS

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

State of the art paper Biochemistry of adipose tissue: an endocrine organ

(2013) Marisa Coelho et al.   Archives of Medical Science

Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity

(2013) Mi-Jeong Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

(2013) Tamara Tchkonia et al.   Cell Metabolism

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice

(2013) P. Luo et al.   DIABETOLOGIA

Abnormal Aldosterone Physiology and Cardiometabolic Risk Factors

(2013) Anand Vaidya et al.   HYPERTENSION

Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice

(2013) Kyeong-Mi Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

(2013) Maria S. Fernández-Alfonso et al.   International Journal of Endocrinology

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

(2013) V. C. De Giusti et al.   Frontiers in Physiology

Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury

(2012) Alan R. Collins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Contribution of glucocorticoid–mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

(2012) Ayumu Hirata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice

(2012) Su-Jung Cho et al.   BRITISH JOURNAL OF NUTRITION

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms

(2012) Nishan S. Kalupahana et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Extrarenal effects of aldosterone

(2012) Aurelie Nguyen Dinh Cat et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Aldosterone, Mineralocorticoid Receptor and the Metabolic Syndrome:Role of the Mineralocorticoid Receptor Antagonists

(2012) Vanessa Ronconi et al.   Current Vascular Pharmacology

Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes

(2012) Chih-Hao Wang et al.   FEBS Journal

Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways

(2012) Ana M. Briones et al.   HYPERTENSION

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

(2012) X. Julia Xu et al.   JOURNAL OF LIPID RESEARCH

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

(2012) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Adipose tissue stem cells: the great WAT hope

(2012) William P. Cawthorn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

(2011) Chunhua Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice

(2011) Soyoung Kim et al.   BIOCHEMICAL PHARMACOLOGY

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

(2011) Kathryn V. Tormos et al.   Cell Metabolism

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets

(2011) J. M. Luther et al.   DIABETOLOGIA

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preferential Fat Deposition in SubcutaneousVersusVisceral Depots Is Associated with Insulin Sensitivity

(2011) Tracey McLaughlin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Mitochondrial dysfunction in obesity

(2011) Juan C Bournat et al.   Current Opinion in Endocrinology Diabetes and Obesity

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Aldosteronism in Causing Obesity-Related Cardiovascular Risk

(2010) David A. Calhoun et al.   CARDIOLOGY CLINICS

Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice

(2010) Juha Ketonen et al.   CIRCULATION JOURNAL

Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome

(2010) Amir Tirosh et al.   CURRENT HYPERTENSION REPORTS

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Spironolactone Improves Glucose and Lipid Metabolism by Ameliorating Hepatic Steatosis and Inflammation and Suppressing Enhanced Gluconeogenesis Induced by High-Fat and High-Fructose Diet

(2010) Tsutomu Wada et al.   ENDOCRINOLOGY

Antiadipogenic Effects of the Mineralocorticoid Receptor Antagonist Drospirenone: Potential Implications for the Treatment of Metabolic Syndrome

(2010) Massimiliano Caprio et al.   ENDOCRINOLOGY

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aldosterone Production and Insulin Resistance in Healthy Adults

(2010) Rajesh Garg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension

(2010) Adam Whaley-Connell et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Impaired Mitochondrial Lipid Oxidation in Obesity

(2009) M. M. Rogge   Biological Research for Nursing

Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice

(2009) Ayumu Hirata et al.   CARDIOVASCULAR RESEARCH

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endothelial Nitric Oxide Synthase Uncoupling and Perivascular Adipose Oxidative Stress and Inflammation Contribute to Vascular Dysfunction in a Rodent Model of Metabolic Syndrome

(2009) Chiara Marchesi et al.   HYPERTENSION

Mineralocorticoid receptor activation in obesity hypertension

(2009) Miki Nagase et al.   HYPERTENSION RESEARCH

Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion

(2009) Haemi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses

(2009) J Hoppmann et al.   JOURNAL OF ENDOCRINOLOGY

The adipose renin–angiotensin system: Role in cardiovascular disease

(2009) Sean Thatcher et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Depot-Specific Differences in Adipogenic Progenitor Abundance and Proliferative Response to High-Fat Diet

(2009) Aaron W.B. Joe et al.   STEM CELLS

Mineralocorticoid receptors in the metabolic syndrome

(2009) Maria-Christina Zennaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

(2008) Ryohei Miyazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human Mesenteric Adipose Tissue Plays Unique Role Versus Subcutaneous and Omental Fat in Obesity Related Diabetes

(2008) Ying-Kui Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-γ, and Proinflammatory Adipokines

(2008) Christine Guo et al.   CIRCULATION

Role of Mitochondrial Dysfunction in Insulin Resistance

(2008) Jeong-a Kim et al.   CIRCULATION RESEARCH

Angiotensin II Reduces Mitochondrial Content in Skeletal Muscle and Affects Glycemic Control

(2008) M. Mitsuishi et al.   DIABETES

Aldosterone Inhibits Insulin-Induced Glucose Uptake by Degradation of Insulin Receptor Substrate (IRS) 1 and IRS2 via a Reactive Oxygen Species-Mediated Pathway in 3T3-L1 Adipocytes

(2008) Tsutomu Wada et al.   ENDOCRINOLOGY

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production

(2008) S DIKALOV et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte

(2008) Marie-Soleil Gauthier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase

(2008) Bettina Johanna Stuck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

General and Abdominal Adiposity and Risk of Death in Europe

(2008) T. Pischon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Primary aldosteronism: cardiovascular, renal and metabolic implications

(2008) Gian-Paolo Rossi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM