Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue

Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice

(2016) Marika Zietak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Central neural control of thermoregulation and brown adipose tissue

(2016) Shaun F. Morrison   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms

(2016) Padmamalini Baskaran et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

(2016) Katrin J. Svensson et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

(2016) Audrey Melvin et al.   Current Atherosclerosis Reports

β-Lapachone Prevents Diet-Induced Obesity by Increasing Energy Expenditure and Stimulating the Browning of White Adipose Tissue via Downregulation of miR-382 Expression

(2016) Won Hee Choi et al.   DIABETES

ALOX5AP Overexpression in Adipose Tissue Leads to LXA4Production and Protection Against Diet-Induced Obesity and Insulin Resistance

(2016) Ivet Elias et al.   DIABETES

PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

(2016) Sun-Sil Choi et al.   DIABETES

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

(2016) Ming Yan et al.   GENES & DEVELOPMENT

Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice

(2016) H Zhang et al.   INTERNATIONAL JOURNAL OF OBESITY

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Human Microbiome and its Association With Health and Diseases

(2016) Asmaa A. Althani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning

(2016) Dianxin Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

19: RESVERATROL IMPROVES INSULIN RESISTANCE WITH ANTI-INFLAMMATORY AND “BROWNING” EFFECTS IN ADIPOSE TISSUE OF OVERWEIGHT HUMANS

(2016) R Gospin et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

(2016) No-Joon Song et al.   Nature Chemical Biology

Effect of Chronic Athletic Activity on Brown Fat in Young Women

(2016) Vibha Singhal et al.   PLoS One

Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles

(2016) Yuan Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

(2016) Yong Chen et al.   Nature Communications

IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity

(2016) Mohd Shahid et al.   Scientific Reports

α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes

(2016) Shangang Zhao et al.   Cell Reports

PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns

(2016) Sandra Côté et al.   Clinical Epigenetics

Exercise Increases and Browns Muscle Lipid in High-Fat Diet-Fed Mice

(2016) Tiffany L. Morton et al.   Frontiers in Endocrinology

Liver X receptor β: new player in the regulatory network of thyroid hormone and ‘browning’ of white fat

(2016) Yifei Miao et al.   Adipocyte

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis

(2016) Verónica García-Alonso et al.   PLoS One

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular and neuroendocrine mechanisms of cancer cachexia

(2015) Maria Carolina S Mendes et al.   JOURNAL OF ENDOCRINOLOGY

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis

(2015) Wei Zhang et al.   Frontiers in Endocrinology

Surgical injury induces local and distant adipose tissue browning

(2015) Alban Longchamp et al.   Adipocyte

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Role of IL-6 in Exercise Training- and Cold-Induced UCP1 Expression in Subcutaneous White Adipose Tissue

(2014) Jakob G. Knudsen et al.   PLoS One

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Bone morphogenic proteins signaling in adipogenesis and energy homeostasis

(2013) Salvatore Modica et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

(2013) Mei Dong et al.   Cell Metabolism

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

(2013) M. K. Montgomery et al.   DIABETOLOGIA

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

(2013) Gwynneth Thomas et al.   Cell Reports

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

(2012) Yun-Hee Lee et al.   Cell Metabolism

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Association of Postburn Fatty Acids and Triglycerides with Clinical Outcome in Severely Burned Children

(2012) Robert Kraft et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

(2012) A. Vitali et al.   JOURNAL OF LIPID RESEARCH

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Sexual Dimorphic Regulation of Body Weight Dynamics and Adipose Tissue Lipolysis

(2012) Verena Benz et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia

(2012) Felipe E. Pedroso et al.   Journal of Cachexia Sarcopenia and Muscle

Central Control of Brown Adipose Tissue Thermogenesis

(2012) Shaun F. Morrison et al.   Frontiers in Endocrinology

New Powers of Brown Fat: Fighting the Metabolic Syndrome

(2011) Jan Nedergaard et al.   Cell Metabolism

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

High Prevalence of Brown Adipose Tissue in Adult Humans

(2011) Paul Lee et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice

(2011) Renaud Mestdagh et al.   JOURNAL OF PROTEOME RESEARCH

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

(2010) Lise Madsen et al.   PLoS One

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions

(2009) Francesca Forner et al.   Cell Metabolism

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

(2009) Tim J. Schulz et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The core gut microbiome, energy balance and obesity

(2009) Peter J. Turnbaugh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice

(2008) Takeshi Kanda et al.   JOURNAL OF CLINICAL INVESTIGATION

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE