Article
Immunology
Sheryl Erica Fernandes, Deepak Kumar Saini
Summary: The study examined the roles of three major kinases in regulating nitric oxide levels in senescent cells, revealing differential regulation compared to non-senescent cells. Through infection assays, an inter-regulatory network unique to infected senescent cells was established, showing how key signalling networks may be rewired in senescent cells rendering them phenotypically different.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zheng Jia, Qian Liu, Ying Xie, Jie Wei, Xiaolin Sun, Fandi Meng, Bin Zhao, Zhenkun Yu, Li Zhao, Zhengjiang Xing
Summary: Coronary artery disease (CAD) is a major cause of death worldwide. The function and mechanism of the Klotho/FGF23 axis in CAD is not fully understood. This study found that levels of Klotho increased and FGF23 decreased after coronary artery bypass graft surgery in CAD patients. The Klotho/FGF23 axis plays a critical role in CAD progression by regulating the ERK/MAPK pathway in cardiomyocytes.
CARDIOVASCULAR TOXICOLOGY
(2023)
Article
Oncology
Hongxv Wang, Danyu Du, Jianwen Huang, Shuai Wang, Xv He, Shengtao Yuan, Jing Xiao
Summary: This study reveals the role of GPR27 in hepatocellular carcinoma (HCC) progression. The results demonstrate that downregulation of GPR27 inhibits cell proliferation and colony formation, while overexpression of GPR27 has the opposite effect. Furthermore, GPR27 expression affects the activation of the MAPK/ERK signaling pathway in HCC cells, thereby modulating cell proliferation.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jack Wellmerling, Rachael E. Rayner, Sheng-Wei Chang, Elizabeth L. Kairis, Sun Hee Kim, Amit Sharma, Prosper N. Boyaka, Estelle Cormet-Boyaka
Summary: Mutations in the CFTR gene lead to cystic fibrosis and the most common mutation F508del causes degradation of CFTR protein. The activation of EGFR-ERK signaling in CF patients was observed and targeting this pathway with ectoine stabilizes CFTR protein, increases its half-life, and improves chloride transport. Ectoine also reduces the production of inflammatory factors from CF cells. Therefore, targeting EGFR-ERK signaling with ectoine may be beneficial for cystic fibrosis patients.
Article
Biotechnology & Applied Microbiology
Chong-Yi Yang, Jie Wang, Jian-Qiu Zhang, Hong-miao Cai
Summary: This study investigated the role of human circular RNA circTXNDC11 in the progression of renal cell carcinoma (RCC), revealing that circTXNDC11 is overexpressed in RCC tissues and cells and associated with advanced cancer stages. Functional studies showed that circTXNDC11 promotes RCC growth and invasion by activating the MAPK/ERK pathway, suggesting circTXNDC11 as a potential therapeutic target for RCC treatment.
Article
Biochemistry & Molecular Biology
Zhen Hua, Rongfang Wei, Mengjie Guo, Zigen Lin, Xichao Yu, Xinying Li, Chunyan Gu, Ye Yang
Summary: This study highlights the role of the YTHDF2/STAT5A/MAP2K2/p-ERK axis in the proliferation of multiple myeloma (MM), and targeting YTHDF2 may be a promising therapeutic strategy.
Article
Cell Biology
Jelena Ostojic, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and CRTC1-3. In melanoma cells, CRTC3 deficiency leads to impaired differentiation and melanosome maturation. CRTC3 interacts with CREB to stimulate OCA2 expression, affecting pigmentation and melanoma risk, and is activated by ERK1/2 signaling.
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sumit Siddharth, Panjamurthy Kuppusamy, Qitong Wu, Arumugam Nagalingam, Neeraj K. Saxena, Dipali Sharma
Summary: Hepatocellular carcinoma (HCC) is a malignant tumor with increasing incidence and mortality rates, and there is a lack of effective therapeutic options for advanced HCC. This study found that the combination of low-dose sorafenib and non-toxic dose of metformin can effectively inhibit the growth and migration potential of HCC cells, enhance the efficacy of sorafenib, and inhibit the MAPK/ERK/Stat3 signaling pathway. The results of in vivo studies also supported these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao, Rong Zhou
Summary: This study found that TARID may inhibit trophoblast invasion and spiral artery remodeling through regulation of the CXCL3/ERK/MAPK pathway, making it a potential therapeutic target for preeclampsia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Longping Huang, Si Chen, Haijun Fan, Dawei Ji, Chuanping Chen, Weiwei Sheng
Summary: GINS2, as a newly discovered oncogene, is overexpressed in pancreatic cancer and positively associated with tumor progression. Its overexpression promotes epithelial-mesenchymal transition (EMT) through activation of ERK/MAPK signaling pathway, contributing to poor prognosis in PC patients.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Mingjie Xie, Huiting Guo, Guohua Lou, Jiping Yao, Yanning Liu, Yi Sun, Zhenggang Yang, Min Zheng
Summary: Hepatitis B virus (HBV) infection is a major public health problem, with a lack of effective antiviral therapy. The study found that MLN4924 has impressive anti-HBV activity by inhibiting HBV replication.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chao Zhang, Shutao Zhao, Yuen Tan, Siwei Pan, Wen An, Qingchuan Chen, Xudong Wang, Huimian Xu
Summary: The high expression of SKA3 in gastric cancer is negatively correlated with the low expression of DUSP2, and is associated with the malignant degree, peritoneal metastasis, and poor prognosis. Further experiments showed that silencing SKA3 expression can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of gastric cancer. Mechanistically, SKA3 negatively regulates DUSP2 and activates the MAPK/ERK pathway to promote gastric cancer progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gi-Hwan Jung, Jae-Han Lee, So-Hee Han, Joong-Seok Woo, Eun-Young Choi, Su-Ji Jeon, Eun-Ji Han, Soo-Hyun Jung, Young-Seok Park, Byung-Kwon Park, Byeong-Soo Kim, Sang-Ki Kim, Ji-Youn Jung
Summary: This study investigated the anticancer effect and mechanism of Chrysin against oral cancer. The results showed that Chrysin induced apoptosis and autophagy in oral cancer cells via the MAPK pathway, with autophagy exerting a cytoprotective effect. This study highlights the therapeutic potential of Chrysin for oral cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jianjun Li, Xuechun Xiao, Hang Wang, Wenhao Wang, Yang Ou, Zhaoyang Wang, Huimin Jiang, Yuxin Liu, Zhen Zhang, Shuang Yang
Summary: This study reveals that the overexpression of USP51 is associated with shorter overall survival in metastatic human lung adenocarcinoma. The study further demonstrates that the CDK4/6-USP51-ZEB1 signaling pathway plays a role in promoting lung adenocarcinoma metastasis.
CANCER GENE THERAPY
(2022)
Article
Oncology
Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L. Sawyers, Anuradha Gopalan, Yu Chen, Brett S. Carver
Article
Cell & Tissue Engineering
Juan Tang, Haixiao Wang, Xiuzhen Huang, Fei Li, Huan Zhu, Yan Li, Lingjuan He, Hui Zhang, Wenjuan Pu, Kuo Liu, Huan Zhao, Jacob Fog Bentzon, Ying Yu, Yong Ji, Yu Nie, Xueying Tian, Li Zhang, Dong Gao, Bin Zhou
Article
Cell Biology
Anand Vasudevan, Prasamit S. Baruah, Joan C. Smith, Zihua Wang, Nicole M. Sayles, Peter Andrews, Jude Kendall, Justin Leu, Narendra Kumar Chunduri, Dan Levy, Michael Wigler, Zuzana Storchova, Jason M. Sheltzer
DEVELOPMENTAL CELL
(2020)
Article
Oncology
Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Xiang Weng, Shruti Sharma, Pallavi Awate, Zhiyi Liu, Dong Gao, Nicholas Mitsiades, Joseph H. Schwab, Yu Chen, Rinath Jeselsohn, Aedin C. Culhane, Myles Brown, Irene Georgakoudi, Constantine S. Mitsiades
Summary: This study reveals the previously underappreciated dependency of tumor cells on HR signaling for anchorage-independent growth and how the metastatic microenvironment restores this malignant property of cancer cells during hormone therapy. The research showed distinct mechanisms of hormone-independent growth and hormone therapy resistance induced by bone marrow stromal cells in breast and prostate cancer cell cultures. Understanding these mechanisms could help refine treatment approaches for hormone therapy-resistant patients with metastatic tumors.
Article
Medicine, Research & Experimental
Fei Li, Qiuyue Yuan, Wei Di, Xinyi Xia, Zhuang Liu, Ninghui Mao, Lin Li, Chunfeng Li, Juan He, Yunguang Li, Wangxin Guo, Xiaoyu Zhang, Yiqin Zhu, Rebiguli Aji, Shangqian Wang, Xinyuan Tong, Hongbin Ji, Ping Chi, Brett Carver, Yong Wang, Yu Chen, Dong Gao
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Genetics & Heredity
Wangxin Guo, Lin Li, Juan He, Zhuang Liu, Ming Han, Fei Li, Xinyi Xia, Xiaoyu Zhang, Yao Zhu, Yu Wei, Yunguang Li, Rebiguli Aji, Hao Dai, Hui Wei, Chunfeng Li, Yu Chen, Luonan Chen, Dong Gao
Article
Oncology
Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Aziz Al'Khafaji, Juliette Bouyssou, Xiang Weng, Shruti Sharma, Joseline Raja, Pallavi Awate, Ryosuke Shirasaki, Huihui Tang, Brian J. Glassner, Zhiyi Liu, Dong Gao, Jordan Bryan, Samantha Bender, Jennifer Roth, Michal Scheffer, Rinath Jeselsohn, Nathanael S. Gray, Irene Georgakoudi, Francisca Vazquez, Aviad Tsherniak, Yu Chen, Alana Welm, Cihangir Duy, Ari Melnick, Boris Bartholdy, Myles Brown, Aedin C. Culhane, Constantine S. Mitsiades
Summary: Our study reveals that treatment-persistent tumor cells in cancer patients adopt a reversible transcriptional program similar to embryonic diapause, which allows them to resist chemotherapy-induced cytotoxicity. Inhibiting Myc activity or interfering with the diapause-like adaptation could be potential therapeutic strategies against chemotherapy-persistent tumor cells.
Article
Chemistry, Multidisciplinary
Yan Zhao, Zhi-Xuan Li, Yan-Jing Zhu, Jing Fu, Xiao-Fang Zhao, Ya-Ni Zhang, Shan Wang, Jian-Min Wu, Kai-Ting Wang, Rui Wu, Cheng-Jun Sui, Si-Yun Shen, Xuan Wu, Hong-Yang Wang, Dong Gao, Lei Chen
Summary: This study investigates the molecular heterogeneity and evolution of hepatobiliary tumors using single-cell RNA sequencing, revealing that certain tumor subpopulations exhibit broad-spectrum drug resistance. The CD44-positive population may play a key role in drug resistance. Shared metabolism advantage clusters across organoids and the combination of GAPDH and NDRG1 are proposed as independent predictors for patient survival.
Article
Cell Biology
Devon A. Lukow, Erin L. Sausville, Pavit Suri, Narendra Kumar Chunduri, Angela Wieland, Justin Leu, Joan C. Smith, Vishruth Girish, Ankith A. Kumar, Jude Kendall, Zihua Wang, Zuzana Storchova, Jason M. Sheltzer
Summary: The study found that transient chromosomal instability can accelerate the development of resistance to anti-cancer therapies in tumor cells, as well as provide phenotypic plasticity for them to adapt to various stressful environments. Furthermore, aneuploidy may be an underexplored cause of therapy failure in human tumors.
DEVELOPMENTAL CELL
(2021)
Article
Cell Biology
Yunqing Gu, Jun Cao, Xinyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Juan He, Xiaoyi Jiang, Jinlan Zhang, Guanghui Shen, Jie Yang, Xichen Zheng, Gaowei Hu, Yuanfei Zhu, Shujuan Du, Yunkai Zhu, Rong Zhang, Jianqing Xu, Fei Lan, Di Qu, Guoliang Xu, Yun Zhao, Dong Gao, Youhua Xie, Min Luo, Zhigang Lu
Summary: The study identified ASGR1 and KREMEN1 as alternative functional receptors for SARS-CoV-2, in addition to ACE2, which together play essential roles in virus entry. The combination of these receptors affects virus susceptibility across different cell types and displays a stronger correlation with virus susceptibility when expressed together. In human lung organoids, a cocktail of antibodies targeting these three receptors provides the most significant blockage of SARS-CoV-2 infection when compared to individual antibodies.
Article
Microbiology
Sha Wang, Siqi Liu, Jing Wang, Jiayue Tao, Mengjiao Wu, Wenfu Ma, Rufeng Wang
Summary: In this study, a new strain capable of cleaving C-glycosidic bonds was isolated from human gut microbiota, offering a practical approach to deglycosylate flavonoids.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pengfei He, Sha Wang, Sen Li, Siqi Liu, Shuqi Zhou, Jing Wang, Jiayue Tao, Dongdong Wang, Rufeng Wang, Wenfu Ma
Summary: Recently, scientists have discovered an enzyme called DgpA/B/C from a human intestinal bacterium that can specifically cleave the C-glycosidic bond of puerarin and also has the activity as a structure isomerase. Through crystal structure and biochemical characterization, they have revealed how DgpA recognizes and oxidizes puerarin and proposed a possible mechanistic model. These findings not only contribute to the understanding of enzyme-mediated C-glycosidic bond breakage and formation, but also have the potential to facilitate stereospecific C-glycoside synthesis in the pharmaceutical industry.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Oncology
Justin Leu, Meredith Akerman, Christopher Mendez, Jonathan W. Lischalk, Todd Carpenter, David Ebling, Jonathan A. Haas, Matthew Witten, Marissa Barbaro, Paul Duic, Lee Tessler, Michael C. Repka
Summary: This study found that stereotactic radiosurgery with concurrent immunotherapy can reduce the risk of local failure in the treatment of primary brain metastases. However, the time interval between diagnosis and treatment does not affect the incidence of radionecrosis or regional failure. Increased MRI maximum axial dimension and a history of previous whole brain radiation therapy are associated with an increased risk of radionecrosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Yiao Jiang, Jiayin Peng, Jiawen Song, Juan He, Man Jiang, Jia Wang, Liya Ma, Yuang Wang, Moubin Lin, Hailong Wu, Zhao Zhang, Dong Gao, Yun Zhao
Summary: The Hedgehog signalling pathway regulates liver lipid metabolism through a long non-coding RNA, Hilnc, which enhances Ppar gamma mRNA stability via the mRNA-binding protein IGF2BP2, thereby affecting obesity and liver steatosis.
Review
Cell Biology
Juan He, Xiaoyu Zhang, Xinyi Xia, Ming Han, Fei Li, Chunfeng Li, Yunguang Li, Dong Gao
JOURNAL OF MOLECULAR CELL BIOLOGY
(2020)