ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

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A genomic and epigenomic atlas of prostate cancer in Asian populations

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Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG

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FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

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Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer

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Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

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TMPRSS2-ERG controls luminal epithelial lineage and antiandrogen sensitivity inPTENandTP53-mutated prostate cancer

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Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis

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ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis

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TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer

(2017) Ken J Kron et al.   NATURE GENETICS

Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells

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SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

(2017) Ping Mu et al.   SCIENCE

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

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Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing

(2017) Qing Xie et al.   Nature Communications

The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

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BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions

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Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations

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Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer

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N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

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EMT: 2016

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Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer

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An Interaction with Ewing’s Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer

(2016) Vivekananda Kedage et al.   Cell Reports

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon

(2016) Dong Gao et al.   PLoS One

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(2015) Adam Abeshouse et al.   CELL

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

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(2015) Daehwan Kim et al.   NATURE METHODS

The oncogene ERG: a key factor in prostate cancer

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Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

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Single luminal epithelial progenitors can generate prostate organoids in culture

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ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells

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The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate

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ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

(2013) Yu Chen et al.   NATURE MEDICINE

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(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

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Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

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(2011) Brett S. Carver et al.   CANCER CELL

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells

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(2011) Michael F. Berger et al.   NATURE

TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model

(2011) Orit Leshem et al.   PLoS One

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

(2010) Ping Chi et al.   NATURE

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Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo

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A causal role for ERG in neoplastic transformation of prostate epithelium

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Role of the TMPRSS2-ERG Gene Fusion in Prostate Cancer

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