Article
Biotechnology & Applied Microbiology
Alyaa Farid, Dina Mohamed, Dina Mostafa, Rawan Tarek, Viola Sherif, Gehan Safwat
Summary: This study investigates the effectiveness of grape seed extract nanoparticles in protecting against amikacin-induced kidney injury. The results show that grape seed extract nanoparticles reduce oxidative stress and inflammation, and have a protective effect on the kidneys.
Article
Nutrition & Dietetics
Huirong Zhang, Guanjie Song, Wenrui Ma, Miaomiao Guo, Xiao Ling, Dan Yu, Weiqiang Zhou, Li Li
Summary: Sea buckthorn (Hippophae rhamnoides) seed oil, which is rich in unsaturated fatty acids, is susceptible to oxidation and rancidity. Microencapsulation technology was used to protect the active substances and prolong the deterioration time and shelf life. The study successfully prepared H. rhamnoides microcapsules using a spray-drying method and optimized the microencapsulation parameters.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Stacy Deshaies, Nicolas Sommerer, Francois Garcia, Laetitia Mouls, Cedric Saucier
Summary: This study analyzed B-type procyanidin dimers and (+)-catechin dimeric oxidation products in grape seed extracts and red wines using UHPLC-Q-Orbitrap MS. The results showed an increasing trend of oxidation markers during grape ripening, while a decreasing trend of these molecules was observed during wine ageing.
Article
Biochemistry & Molecular Biology
Eva Szabo, Tamas Marosvolgyi, Gabor Szilagyi, Laszlo Korosi, Janos Schmidt, Kristof Csepregi, Laszlo Mark, Agnes Bona
Summary: Research has shown a correlation between the polyphenol and fatty acid content and the antioxidant capacity in grape pomace, with different grape varieties exhibiting varying levels of antioxidant activity and polyphenol concentration; grape pomace is a more promising source for the production of nutraceuticals compared to native grape seeds.
Article
Chemistry, Multidisciplinary
Tianyou Wang, Qianqian Fan, Jiaxu Hong, Zhan Chen, Xujiao Zhou, Jianhua Zhang, Yiqin Dai, Hao Jiang, Zhipeng Gu, Yiyun Cheng, Yiwen Li
Summary: The study reports a direct fabrication strategy towards polyphenol nanoparticles with tunable size, excellent biocompatibility, and reactive oxygen species (ROS) scavenging capacities from grape seed via an enzymatic polymerization method. The resulting nanoparticles can efficiently prevent cell damage from ROS and exert promising in vivo antioxidant therapeutic effects on several oxidative stress-related diseases. This research can stimulate the development of more kinds of low-cost, safe, and efficient biomass-based antioxidative nanomaterials via similar fabrication methodologies.
Article
Veterinary Sciences
Sawsan M. A. El-Sheikh, Fatma M. Youssef, Haidi I. Mohamed, Gaber El-Saber Batiha, Ashraf Albrakati, Azza A. A. Galal
Summary: The study found that treating Pasteurella multocida infection in rabbits with grape seed extract (GSE) can improve infection-induced injuries and abnormal biomarkers, and effectively regulate physiological parameters such as body weight and blood parameters in rabbits. The results of this study endorse the administration of GSE for the treatment of Pasteurellosis in rabbits, and further research is needed to determine the optimal dosage and duration.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Engineering, Chemical
Ante Loncaric, Mico Patljak, Ante Blazevic, Antun Jozinovic, Jurislav Babic, Drago Subaric, Anita Pichler, Ivana Flanjak, Toni Kujundzic, Borislav Milicevic
Summary: The combination of grape alcohol and volatile compounds plays an important role in the quality and aroma of brandy production. This study explores the possibility of using different grape varieties to produce brandy and investigates the changes in volatile compounds during the production process.
Article
Biochemistry & Molecular Biology
Hongbin Wang, Qiyu Tian, Zhixin Xu, Min Du, Mei-Jun Zhu
Summary: Grape pomace (GP), a rich source of bioactive compounds, has protective effects against colorectal cancer (CRC) development by suppressing cell proliferation and modulating DNA methylation. This study used metabolomic analysis to profile fecal metabolomic changes in a mouse CRC model in response to GP supplementation. GP supplementation led to significant changes in various metabolites, including bile acids, amino acids, fatty acids, phenols/flavonoids, glycerolipids, carbohydrates, organic acids, and others. GP supplementation upregulated the expression of farnesoid X receptor (FXR) downstream genes, decreased fecal urease activity, upregulated the DNA repair enzyme MSH2, decreased the DNA damage marker gamma-H2AX, and decreased the ATM pathway protein MDM2. These findings provide valuable metabolic clues for understanding the protective effects of GP supplementation against CRC development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Shaowen Liu, Aijuan Bai, Le Song, Nan Zou, Yongtao Han, Li Zhou, Chuanshan Yu, Changjun Li, Canping Pan
Summary: A convenient and fast multi-residue method has been developed for the efficient identification and quantification of 72 pesticides in red and white grape wines. The method achieved consistent recoveries and reduced sample matrix compounds. It was successfully used to detect pesticide residues in commercial grape wines.
Article
Plant Sciences
Yongzhou Li, Liangliang He, Yinhua Song, Peng Zhang, Doudou Chen, Liping Guan, Sanjun Liu
Summary: In this study, volatile compounds in the pulp and skin of five table grape cultivars with different aroma types were qualitatively analyzed. The analysis identified 215 aroma compounds, including esters, terpenes, and alcohols. The transcriptomic analysis and terpene profiling data revealed several candidate genes and transcription factors involved in aroma biosynthetic regulation. The results provide new insights into the regulation of different aromas in grapes.
Article
Environmental Sciences
Ahmed Alsayadi, Nael Abutaha, Bader O. Almutairi, Fahd A. Al-Mekhlafi, Mohamed A. Wadaan
Summary: This research evaluates the antioxidant and anticancer activities of the polyherbal formulation HF6. The hexane extract (HF6H) showed significant cytotoxicity against cancer cell lines and moderate cytotoxicity against non-cancer cells, indicating its potential as a promising remedy. The phytochemical screening and GC-MS analysis revealed the presence of bioactive compounds in HF6H. Further investigation on animal models is recommended to determine its toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Venkatadri Babu, J. Irshad Ahamed, Agastian Paul, Sajad Ali, Irfan A. Rather, Jamal S. M. Sabir
Summary: This study evaluated the in vitro antibacterial, antioxidant, and anti-breast cancer properties of vegetable seed extracts using different solvents. The ethyl acetate extract exhibited strong inhibitory effects against bacteria and showed notable scavenging activity against DPPH and hydrogen peroxide. In addition, it demonstrated potential anticancer properties against human breast cancer cells. Molecular docking experiments identified a compound with promising binding energy, suggesting further investigation into its anticancer potential and pharmacological characteristics.
Article
Food Science & Technology
Raquel Torrijos, Laura Righetti, Martina Cirlini, Luca Calani, Jordi Manes, Giuseppe Meca, Chiara Dall'Asta
Summary: The objective of this study was to investigate the phytochemical profile of yellow and oriental mustard flour and bran fractions. The analysis revealed differences in volatile compounds and bioactive compounds between the two mustard species, with yellow mustard being richer in certain phenolic acids. Additionally, the volatile profile of yellow mustard seeds was described for the first time in this study. The findings suggest that the bran fraction, as a by-product of seed processing, is a valuable source of bioactive compounds for various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Raquel Torrijos, Laura Righetti, Martina Cirlini, Luca Calani, Jordi Manes, Giuseppe Meca, Chiara Dall Asta
Summary: The phytochemical profile and bioactive fraction of yellow mustard and oriental mustard were studied. Various volatile compounds and phenolic compounds were identified, distinguishing the two mustard species. The bran fraction was found to be rich in bioactive compounds and could be used for the recovery of polyphenols.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Dimitrina Krasteva, Yavor Ivanov, Zlatina Chengolova, Tzonka Godjevargova
Summary: The aim of this study was to evaluate the total phenolic content, composition, and antioxidant and antibacterial activities of four grape seed extracts (Cabernet Sauvignon, Marselan, Pinot Noir, and Tamyanka). The extracts showed high total phenolic content values and exhibited antioxidant and antibacterial properties. The individual components in the extracts were determined and high contents of catechin, epicatechin, and procyanidin B1 were found. The extracts also demonstrated significant antimicrobial activity against tested bacteria.
Article
Biotechnology & Applied Microbiology
Onder Aybastier, Sam Dawbaa, Cevdet Demir, Oguzhan Akgun, Engin Ulukaya, Ferda Ari
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2018)
Article
Biochemical Research Methods
Saliha Sahin, Onder Aybastier, Sam Dawbaa, Busra Karkar, Turgay cakmak
Article
Chemistry, Physical
Asaf Evrim Evren, Sam Dawbaa, Demokrat Nuha, Sule Aybuke Yavuz, Ulkuye Dudu Gul, Leyla Yurttas
Summary: The study focuses on the development of new antimicrobial agents, designed and synthesized new compounds, and elucidated their structures using various techniques. The research found valuable antibacterial effects of the compounds, and the structure-activity relationship study provided guidance for the discovery of new antimicrobials.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Analytical
Onder Aybastier, Cevdet Demir
Summary: The study focused on the oxidation of DNA due to exposure to reactive oxygen species (ROS) and its role in various diseases, including cancer and neurodegenerative diseases. A GC-MS/MS method was developed for ultrasensitive detection of individual DNA damage products, and multiple response surface methodology (MRSM) was used to optimize the derivatization conditions. The presence of antioxidants resulted in a significant decrease in DNA base damage products, as shown by the study.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Inorganic & Nuclear
Sam Dawbaa, Asaf Evrim Evren, Zerrin Canturk, Leyla Yurttas
Summary: Novel 2-heteroaryl-N-[4-(substituted aryl)thiazol-2-yl]propanamide derivatives were synthesized and tested for antimicrobial activity, with compounds 7e and 7f showing the highest antibacterial activity. Some derivatives displayed cytotoxic activity against human leukemia cells and monocytic leukemia cells.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2021)
Article
Chemistry, Medicinal
Asaf Evrim Evren, Demokrat Nuha, Sam Dawbaa, Begum Nurpelin Saglik, Leyla Yurttas
Summary: In this study, a new series of 2-thiazolyl hydrazone derivatives were synthesized and evaluated for their inhibitory effects on monoamine oxidase enzymes. Significant results were obtained, with several compounds showing potent and selective inhibition. Molecular docking, molecular dynamics simulations, and QSAR studies were performed to explore the structure-activity relationship. This study represents the first investigation of dual inhibitors on both MAO and aromatase enzymes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Arwa AL-Adhreai, Mohammed ALSaeedy, Ali Alrabie, Inas Al-Qadsy, Sam Dawbaa, ZabnAllah M. Alaizeri, Hisham A. Alhadlaq, Abdulrahman Al-Kubati, Maqusood Ahamed, Mazahar Farooqui
Summary: A new series of isoxazolidine compounds were designed, synthesized and characterized for their antimicrobial and antioxidant properties. The compounds showed significant activity against various bacterial species and fungi, with some compounds also exhibiting high antioxidant effects. Molecular docking studies indicated that the synthesized compounds had a better binding mode to the target protein compared to the standard drug.
Article
Chemistry, Medicinal
Sam Dawbaa, Asaf Evrim Evren, Begum Nurpelin Saglik, Nalan Gundogdu-Karaburun, Ahmet Cagri Karaburun
Summary: In this study, a series of hybrid molecules were designed as potential selective monoamine oxidase inhibitors for the treatment of Parkinson's disease. In vitro experiments showed that compounds 3a, 3c, and 3e demonstrated inhibitory activity against both MAO-A and MAO-B, with compound 3c exhibiting the most promising inhibition. Molecular dynamics simulation indicated that the stability of the complex formed between compound 3c and MAO-A was poor.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Sam Dawbaa, Demokrat Nuha, Asaf Evrim Evren, Meral Yilmaz Cankilic, Leyla Yurtta, Gulhan Turan
Summary: We synthesized a series of oxadiazole and triazole derivatives and tested their antimicrobial and antioxidant activity. The compounds were analyzed through NMR and HRMS, and their pharmacokinetic profile was predicted through in silico calculations. However, none of the compounds showed significant antibacterial or antifungal activity compared to reference agents. Some compounds exhibited antioxidant potency, but not equivalent to ascorbic acid. Molecular docking and molecular dynamics simulation studies were conducted to analyze the compounds' binding modes and mechanism of enzyme interaction.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Asaf Evrim Evren, Demokrat Nuha, Sam Dawbaa, Abdullah Burak Karaduman, Beguem Nurpelin Saglik, Leyla Yurttas
Summary: A new series of thiazole derivatives were synthesized and compounds 5a, 5b, and 5c showed promising anticancer activity against MCF7 cells, but not against A549 cells or L929 healthy cells. The acetamide moiety was found to play a pivotal role in the anticancer activity. Molecular docking and dynamics simulation studies revealed the binding modes and stability of the active compounds with the enzyme. The distance between the H-bond rich zone of the ligand and the heteroaryl ring system of the ligand was found to significantly impact the aromatase inhibitory activity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
