Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte

(2017) Letizia Mezzasoma et al.   MEDIATORS OF INFLAMMATION

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications

(2016) Roberto Bravo-Sagua et al.   Frontiers in Physiology

Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

(2015) Wenxiu Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Preadipocyte proliferation is elevated by calcium sensing receptor activation

(2015) Gladys Rocha et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Inflammation and the depot-specific secretome of human preadipocytes

(2015) Yi Zhu et al.   Obesity

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

(2014) M. G. Ghonime et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

(2013) K Leach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impact of Clinically Relevant Mutations on the Pharmacoregulation and Signaling Bias of the Calcium-Sensing Receptor by Positive and Negative Allosteric Modulators

(2013) Katie Leach et al.   ENDOCRINOLOGY

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

The role of the calcium-sensing receptor in human disease

(2012) Bryan K. Ward et al.   CLINICAL BIOCHEMISTRY

Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue

(2012) Mariana Cifuentes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

(2012) Clare M. Reynolds et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Biased agonism of the calcium-sensing receptor

(2011) Alex Rojas Bie Thomsen et al.   CELL CALCIUM

The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

(2011) Tim B. Koenen et al.   ENDOCRINOLOGY

Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

(2011) Anna E. Davey et al.   ENDOCRINOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY