The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide

Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure

(2014) Lei Shang et al.   BMC NEUROSCIENCE

Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish

(2014) I A Viringipurampeer et al.   CELL DEATH AND DIFFERENTIATION

B-9-3, a novel β-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro

(2014) Abdelkader Daoud et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia–reperfusion-induced retinal damage

(2014) Galina Dvoriantchikova et al.   EXPERIMENTAL EYE RESEARCH

Chemical profile- and pharmacokinetics-based investigation of the synergistic property of Platycodonis Radix in Traditional Chinese Medicine formula Shengxian Decoction

(2014) Feng Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Characterization of TNF-induced caspase-independent necroptosis

(2014) Hirofumi Sawai   LEUKEMIA RESEARCH

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells

(2014) Weiping Lin et al.   TUMOR BIOLOGY

A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma

(2013) Ning Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel necroptosis inhibitor—necrostatin-21 and its SAR study

(2013) Zhijie Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response

(2013) Ju-Fang Huang et al.   BMC NEUROSCIENCE

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis

(2013) Justyna Sosna et al.   Cell Communication and Signaling

Protective effects of timosaponin B-II on high glucose-induced apoptosis in human umbilical vein endothelial cells

(2013) Changrun Guo et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol

(2013) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability

(2012) Sungwoon Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Timosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina

(2012) Ju-Fang Huang et al.   BMC Complementary and Alternative Medicine

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

(2012) S Jouan-Lanhouet et al.   CELL DEATH AND DIFFERENTIATION

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation

(2011) L Cabon et al.   CELL DEATH AND DIFFERENTIATION

Multiple death pathways in TNF-treated fibroblasts: RIP3- and RIP1-dependent and independent routes

(2011) Duan-Wu Zhang et al.   CELL RESEARCH

Necroptosis: An emerging form of programmed cell death

(2011) Wei Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

(2011) Marion C. Bonnet et al.   IMMUNITY

RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons

(2011) Wei-Wei Chen et al.   JOURNAL OF NEUROCHEMISTRY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri

(2011) K.-J. SONG et al.   PARASITE IMMUNOLOGY

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

(2011) N Vanlangenakker et al.   Cell Death & Disease

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

(2010) Y-T Wu et al.   CELL DEATH AND DIFFERENTIATION

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells

(2009) Wen-Quan Lu et al.   ARCHIVES OF PHARMACAL RESEARCH

Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-κB and p38 pathways

(2009) Ji-Yeon Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

(2009) Frank W. King et al.   PLoS One

Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7

(2008) Weihong Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells

(2008) L.-K. Sy et al.   CANCER RESEARCH