Biological functions of Elabela, a novel endogenous ligand of APJ receptor

ELABELA and an ELABELA Fragment Protect against AKI

(2017) Hong Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

(2017) Lena Ho et al.   SCIENCE

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders

(2017) Adrien Flahault et al.   Frontiers in Endocrinology

Targeting calcium signaling in cancer therapy

(2017) Chaochu Cui et al.   Acta Pharmaceutica Sinica B

Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions

(2016) Alexandre Murza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

(2016) Mireia Perez-Camps et al.   eLife

Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity

(2015) Juri Hamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart

(2015) Ábel Perjés et al.   BASIC RESEARCH IN CARDIOLOGY

Apelin: an antithrombotic factor that inhibits platelet function

(2015) F. Adam et al.   BLOOD

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

(2015) Mangmang Li et al.   Cell Stem Cell

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway

(2015) Lena Ho et al.   Cell Stem Cell

Apelin/APJ signaling in hypoxia-related diseases

(2015) Lu He et al.   CLINICA CHIMICA ACTA

Apelin receptors: From signaling to antidiabetic strategy

(2015) C. Chaves-Almagro et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling

(2015) Cheng Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central action of ELABELA reduces food intake and activates arginine vasopressin and corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus

(2015) Putra Santoso et al.   NEUROREPORT

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

(2015) Peiran Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems

(2015) Zhi Wang et al.   Scientific Reports

ELABELA: a novel hormone in cardiac development acting as a new endogenous ligand for the APJ receptor

(2014) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

(2014) Nigel A. Chapman et al.   Biochemistry and Cell Biology

Small proteins, big roles: The signaling protein Apela extends the complexity of developmental pathways in the early zebrafish embryo

(2014) Michal Reichman-Fried et al.   BIOESSAYS

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors

(2014) A. Pauli et al.   SCIENCE

Apelin-APJ Signaling Is a Critical Regulator of Endothelial MEF2 Activation in Cardiovascular Development

(2013) Yujung Kang et al.   CIRCULATION RESEARCH

ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor

(2013) Serene C. Chng et al.   DEVELOPMENTAL CELL

Increased Bone Mass in Mice Lacking the Adipokine Apelin

(2013) Lalita Wattanachanya et al.   ENDOCRINOLOGY

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

cAMP in the pituitary: an old messenger for multiple signals

(2013) Erika Peverelli et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of feeding behavior, gastrointestinal function and fluid homeostasis by apelin

(2013) Shuang-Yu Lv et al.   PEPTIDES

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

(2013) Wang Wang et al.   Journal of the American Heart Association

Apelin-13 microinjection into the paraventricular nucleus increased sympathetic nerve activity innervating brown adipose tissue in rats

(2012) Takayuki Masaki et al.   BRAIN RESEARCH BULLETIN

A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice

(2012) S. Sakimoto et al.   DEVELOPMENT

Involvement of the apelin receptor APJ in Fas-induced liver injury

(2012) Hiroaki Yasuzaki et al.   LIVER INTERNATIONAL

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Neuroprotection of apelin and its signaling pathway

(2012) Baohua Cheng et al.   PEPTIDES

Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release

(2011) Annabelle Reaux-Le Goazigo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

(2011) Suparna M. Chandra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice

(2011) Hong Chen et al.   PEPTIDES

Central apelin-13 inhibits food intake via the CRF receptor in mice

(2011) Shuang-Yu Lv et al.   PEPTIDES

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

(2010) Cédric Dray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity

(2010) A. Verma et al.   BLOOD

Identification and functional analysis of endothelial tip cell-enriched genes

(2010) R. del Toro et al.   BLOOD

Upregulation of the apelin–APJ pathway promotes neointima formation in the carotid ligation model in mouse

(2010) Yoko Kojima et al.   CARDIOVASCULAR RESEARCH

Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms

(2010) Patrick Yue et al.   ENDOCRINOLOGY

Stimulus-Specific Neuroendocrine Responses to Osmotic Challenges in Apelin Receptor Knockout Mice

(2010) E. M. Roberts et al.   JOURNAL OF NEUROENDOCRINOLOGY

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

(2010) S. L. Pitkin et al.   PHARMACOLOGICAL REVIEWS

Endogenous regulation of cardiovascular function by apelin-APJ

(2009) David N. Charo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

G Protein-Coupled Receptor APJ and Its Ligand Apelin Act Downstream of Cripto to Specify Embryonic Stem Cells Toward the Cardiac Lineage Through Extracellular Signal-Regulated Kinase/p70S6 Kinase Signaling Pathway

(2009) Cristina D'Aniello et al.   CIRCULATION RESEARCH

Abnormal fluid homeostasis in apelin receptor knockout mice

(2009) Emma M Roberts et al.   JOURNAL OF ENDOCRINOLOGY

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

(2009) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retardation of Retinal Vascular Development in Apelin-Deficient Mice

(2008) Atsushi Kasai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli

(2008) M. Azizi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of extracellular signal-regulated kinases (ERK) in leptin-induced hypertension

(2007) Grażyna Wójcicka et al.   LIFE SCIENCES