Journal
BRAIN RESEARCH BULLETIN
Volume 87, Issue 6, Pages 540-543Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2012.02.004
Keywords
Apelin; Paraventricular nucleus; c-Fos-like immunoreactivity; Brown adipose tissue; Sympathetic nerve activity
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Funding
- Japanese Ministry of Education, Science and Culture and Research on Measures for Intractable Diseases
- Japanese Ministry of Health, Welfare and Labor, Japan
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The aim of present study is to clarify the role of apelin in regulating energy homeostasis in brown adipose tissue (BAT). We examined the central effects of apelin-13 on the brain c-fos like immunoreactivity (c-FLI), BAT temperature and the activity of the sympathetic nerve activity innervating BAT in rats. In the hypothalamus, central infusion into the third cerebral ventricle (i3vt) of apelin-13 caused induction of c-FLI in the paraventricular nucleus (PVN) compared with the controls (PBS-treated) group. In addition, microinjection of apelin-13 into the PVN produced significant increases in BAT temperature. Furthermore, microinjection of apelin-13 treatment increased BAT sympathetic nerve activity compared with controls. We conclude that apelin-13 microinjection into PVN increases sympathetic nerve activity innervating BAT. (C) 2012 Elsevier Inc. All rights reserved.
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