Role of immune system in tumor progression and carcinogenesis

Adoptive Cell Transfer for Patients with Metastatic Melanoma: The Potential and Promise of Cancer Immunotherapy

(2017) Giao Q. Phan et al.   Cancer Control

MicroRNA-361-5p Inhibits Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma

(2016) Jian-Jun Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen

(2016) R. Andersen et al.   CLINICAL CANCER RESEARCH

Part I: Checkpoint inhibitors in cancer therapy

(2016) Adil I Daud   Immunotherapy

Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

(2016) Nicolas Jacquelot et al.   JOURNAL OF CLINICAL INVESTIGATION

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Analysis of histological and immunological parameters of metastatic lymph nodes from colon cancer patients reveals that T-helper 1 type immune response is associated with improved overall survival

(2016) Eran Nizri et al.   MEDICINE

CXCR6-CXCL16 axis promotes prostate cancer by mediating cytoskeleton rearrangement via Ezrin activation and αvβ3 integrin clustering

(2016) Rajesh Singh et al.   Oncotarget

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Immuno-oncology combinations: raising the tail of the survival curve

(2016) Samuel J. Harris et al.   Cancer Biology & Medicine

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance

(2015) Birgitte Grum-Schwensen et al.   BMC CANCER

IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment

(2015) Luciana Benevides et al.   CANCER RESEARCH

The Evolution of T-cell Therapies for Solid Malignancies

(2015) K. Fousek et al.   CLINICAL CANCER RESEARCH

Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling

(2015) J. S. Bowers et al.   CLINICAL CANCER RESEARCH

CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma

(2015) Sun Wook Cho et al.   ENDOCRINE-RELATED CANCER

Generation and Preclinical Characterization of an NKp80-Fc Fusion Protein for Redirected Cytolysis of Natural Killer (NK) Cells against Leukemia

(2015) Gang Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma

(2015) Carmela Rozera et al.   Journal of Translational Medicine

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

The STING pathway and the T cell-inflamed tumor microenvironment

(2015) Seng-Ryong Woo et al.   TRENDS IN IMMUNOLOGY

CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases

(2015) Hina Mir et al.   Oncotarget

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

(2015) Lotte Spel et al.   Oncotarget

STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis

(2015) C. Yue et al.   Cancer Immunology Research

Increased sMICA and TGFβ1levels in HNSCC patients impair NKG2D-dependent functionality of activated NK cells

(2015) Stephan Klöß et al.   OncoImmunology

Abstract 3615: IL-6/STAT3-dependent immunosuppressive function of tumor-infiltrating dendritic cells in colorectal cancer

(2015) Yosuke Ono et al.   CANCER RESEARCH

Abstract 4003: Clinical and biological significance of CXCR6 in lung cancer

(2015) Hina Mir et al.   CANCER RESEARCH

Chemokines in tumor progression and metastasis

(2015) Purvaba J. Sarvaiya et al.   Oncotarget

CCR9/CCL25 expression in non-small cell lung cancer correlates with aggressive disease and mediates key steps of metastasis

(2015) Pranav Gupta et al.   Oncotarget

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges

(2014) D. B. Hoelzinger et al.   CANCER RESEARCH

Effect of tumor cells and tumor microenvironment on NK-cell function

(2014) Massimo Vitale et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

IL-10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset

(2014) Duygu Sag et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1

(2014) Eliana Pivetta et al.   MATRIX BIOLOGY

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Tumor-Associated Neutrophils as a New Prognostic Factor in Cancer: A Systematic Review and Meta-Analysis

(2014) Meixiao Shen et al.   PLoS One

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful

(2014) H.-J. Kim et al.   Cancer Immunology Research

Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

(2014) T.-C. Wu et al.   Cancer Immunology Research

IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN-γRelease by Autologous NK Cells

(2014) Fabio Morandi et al.   Journal of Immunology Research

CXCL13–CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis

(2013) Subir Biswas et al.   BREAST CANCER RESEARCH AND TREATMENT

The chemokine system, and its CCR5 and CXCR4 receptors, as potential targets for personalized therapy in cancer

(2013) Polina Weitzenfeld et al.   CANCER LETTERS

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

(2013) Virna Cortez-Retamozo et al.   IMMUNITY

Tumor associated macrophages and neutrophils in cancer

(2013) Maria Rosaria Galdiero et al.   IMMUNOBIOLOGY

Lung tumor NF-κB signaling promotes T cell–mediated immune surveillance

(2013) Emily L. Hopewell et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of IL-1  in the Early Tumor Cell-Induced Angiogenic Response

(2013) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

T and NK cells: two sides of tumor immunoevasion

(2013) Doriana Fruci et al.   Journal of Translational Medicine

Programmed death ligand-1 expression in non-small cell lung cancer

(2013) Vamsidhar Velcheti et al.   LABORATORY INVESTIGATION

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Dendritic Cells in the Cancer Microenvironment

(2013) Yang Ma et al.   Journal of Cancer

Tumor-Primed NK Cells: Waiting for the Green Light

(2013) May Sabry et al.   Frontiers in Immunology

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

(2013) Joanna Baginska et al.   Frontiers in Immunology

Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?

(2012) Laura Kühnelt-Leddihn et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity

(2012) G. Pietra et al.   CANCER RESEARCH

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Improved Outcome of High-Risk Early HER2 Positive Breast Cancer With High CXCL13-CXCR5 Messenger RNA Expression

(2012) Evangelia Razis et al.   Clinical Breast Cancer

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

(2012) Jamie L Harden et al.   IMMUNOLOGICAL INVESTIGATIONS

CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid

(2012) Cho Rong Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A tale of two tumours: Comparison of the immune escape strategies of contagious cancers

(2012) Hannah V. Siddle et al.   MOLECULAR IMMUNOLOGY

TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk

(2012) Gisela Barbisan et al.   TUMOR BIOLOGY

Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix

(2012) Hélène Salmon et al.   OncoImmunology

Clinical implication of HLA class I expression in breast cancer

(2011) Koichi Kaneko et al.   BMC CANCER

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Maximal T Cell-Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells

(2011) A. Gonzalez-Martin et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response

(2011) Siew-Min Ong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prolonged Antitumor NK Cell Reactivity Elicited by CXCL10-Expressing Dendritic Cells Licensed by CD40L+CD4+ Memory T Cells

(2011) K. Shimizu et al.   JOURNAL OF IMMUNOLOGY

Role of CXCL13-CXCR5 Crosstalk Between Malignant Neuroblastoma Cells and Schwannian Stromal Cells in Neuroblastic Tumors

(2011) F. Del Grosso et al.   MOLECULAR CANCER RESEARCH

Murine Melanoma-Infiltrating Dendritic Cells Are Defective in Antigen Presenting Function Regardless of the Presence of CD4+CD25+ Regulatory T Cells

(2011) Haley Ataera et al.   PLoS One

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+ T lymphocytes

(2011) M. Gooden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Chemokines as mediators of tumor angiogenesis and neovascularization

(2010) Ellen C. Keeley et al.   EXPERIMENTAL CELL RESEARCH

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide

(2010) Praveen K. Sharma et al.   INTERNATIONAL JOURNAL OF CANCER

Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis

(2010) Xian-Zong Ye et al.   Journal of Genetics and Genomics

The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

CXCR4 and cancer

(2010) Bungo Furusato et al.   PATHOLOGY INTERNATIONAL

Biomarkers of suppressed natural killer (NK) cell function in metastatic melanoma: Decreased NKG2D and increased CD158a receptors on CD3–CD16+ NK cells

(2009) Gordana Konjević et al.   BIOMARKERS

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Toll-like receptor 9 agonists promote IL-8 and TGF-β1production via activation of nuclear factor κB in PC-3 cells

(2009) Jin-ming Di et al.   CANCER GENETICS AND CYTOGENETICS

Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion

(2009) Shailesh Singh et al.   CANCER LETTERS

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

(2009) Kellie A. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucins in ovarian cancer diagnosis and therapy

(2009) Subhash C Chauhan et al.   Journal of Ovarian Research

Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

(2008) Morgan O'Hayre et al.   BIOCHEMICAL JOURNAL

Inefficient presentation of tumor-derived antigen by tumor-infiltrating dendritic cells

(2008) Patrizia Stoitzner et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer related inflammation: The macrophage connection

(2008) Antonio Sica et al.   CANCER LETTERS

CX3CR1 Is Expressed by Prostate Epithelial Cells and Androgens Regulate the Levels of CX3CL1/Fractalkine in the Bone Marrow: Potential Role in Prostate Cancer Bone Tropism

(2008) W. L. Jamieson et al.   CANCER RESEARCH

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Activation of CCR9/CCL25 in Cutaneous Melanoma Mediates Preferential Metastasis to the Small Intestine

(2008) F. F. Amersi et al.   CLINICAL CANCER RESEARCH