期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 119, 期 7, 页码 5028-5042出版社
WILEY
DOI: 10.1002/jcb.26663
关键词
adoptive T cell transfer; chemokines; cytokines; immune surveillance; micro-environment
资金
- Indian Council of Medical Research (ICMR), New Delhi, India
- Dept of Science and Technology New Delhi [SB/4S/LS-107/2013]
Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that helps in progression. In between eliminating and establishment phase, equilibrium and escaping phase regulate the immune cells response. During immune-escaping, (1) the antigenic response generated is either inadequate, or focused entirely on tolerance, and (2) immune response generated is specific and effective, but the tumor skips immune recognition. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy.
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