Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK

Targeting ADAM17 Sheddase Activity in Cancer

(2016) Armando Rossello et al.   CURRENT DRUG TARGETS

Phosphatidylserine exposure is required for ADAM17 sheddase function

(2016) Anselm Sommer et al.   Nature Communications

Control of ADAM17 activity by regulation of its cellular localisation

(2016) Inken Lorenzen et al.   Scientific Reports

High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells

(2015) Renzhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNFα Shedding in Mechanically Stressed Cardiomyocytes is Mediated by Src Activation of TACE

(2015) Airu Niu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

(2015) Sarah Louise Dombernowsky et al.   Nature Communications

Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH3 Interactions

(2015) Iivari Kleino et al.   PLoS One

Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms

(2014) Sariah Liu et al.   CANCER TREATMENT REVIEWS

Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells

(2014) Charles G. Miller et al.   MOLECULAR BIOLOGY OF THE CELL

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17

(2013) Jeanette Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Src Kinase Blocks High Glucose-Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice

(2013) K. Taniguchi et al.   DIABETES

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Src mediates the mechanical activation of myogenesis by activating TNF -converting enzyme

(2013) A. Niu et al.   JOURNAL OF CELL SCIENCE

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

(2013) Katherine J. Elliott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PI3Kγ contributes to MEK1/2 activation in oxidative glutamate toxicity via PDK1

(2013) Jong Seong Ha et al.   JOURNAL OF NEUROCHEMISTRY

A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by α5β1 Integrin in Kidney Mesangial Cells

(2012) Pal Gooz et al.   PLoS One

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

(2011) Thorsten Maretzky et al.   Nature Communications

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit

(2010) Arindam Saha et al.   GASTROENTEROLOGY

Stimulation of Platelet-derived Growth Factor Receptor β (PDGFRβ) Activates ADAM17 and Promotes Metalloproteinase-dependent Cross-talk between the PDGFRβ and Epidermal Growth Factor Receptor (EGFR) Signaling Pathways

(2010) Karen Mendelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

(2010) Victoria Bolós   OncoTargets and Therapy

ADAM17 as a Therapeutic Target in Multiple Diseases

(2009) Joaquin Arribas et al.   CURRENT PHARMACEUTICAL DESIGN

PKC- 1 Mediates Glucose-Induced Akt Activation and TGF- 1 Upregulation in Mesangial Cells

(2009) D. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE