Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes

Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior

(2017) Dharma Rao Tompa et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Effects of helix and fingertip mutations on the thermostability of xyn11A investigated by molecular dynamics simulations and enzyme activity assays

(2017) Thana Sutthibutpong et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural, functional and molecular dynamics analysis of the native and mutated actin to study its effect on congenital myopathy

(2016) Faeze Sadat Mohajer et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation

(2016) Shabana Kouser Ali et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach

(2016) D. Thirumal Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Impact of disease-causing mutations on inter-domain interactions in cMyBP-C: a steered molecular dynamics study

(2016) Navaneethakrishnan Krishnamoorthy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

OUP accepted manuscript

(2016)   NUCLEIC ACIDS RESEARCH

Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer

(2016) Iris N. Smith et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Inherited PTEN mutations and the prediction of phenotype

(2016) Nicholas R. Leslie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders

(2015) Sean B. Johnston et al.   BIOCHEMISTRY

ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability

(2015) Vincent Frappier et al.   NUCLEIC ACIDS RESEARCH

Superdomains in the protein structure hierarchy: The case of PTP-C2

(2015) Donald T. Haynie et al.   PROTEIN SCIENCE

Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association

(2015) Brandon M. Butler et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

(2014) Laura Spinelli et al.   JOURNAL OF MEDICAL GENETICS

Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism

(2014) T W Frazier et al.   MOLECULAR PSYCHIATRY

A Coarse-Grained Elastic Network Atom Contact Model and Its Use in the Simulation of Protein Dynamics and the Prediction of the Effect of Mutations

(2014) Vincent Frappier et al.   PLoS Computational Biology

When Overgrowth Bumps Into Cancer: The PTEN-Opathies

(2013) JESSICA MESTER et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Cowden Syndrome-Related Mutations in PTEN Associate with Enhanced Proteasome Activity

(2013) X. He et al.   CANCER RESEARCH

Protein dynamics and motions in relation to their functions: several case studies and the underlying mechanisms

(2013) Li-Quan Yang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Role of N-terminal residues on folding and stability of C-phycoerythrin: simulation and urea-induced denaturation studies

(2013) Khalid Anwer et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Mechanisms of Disease-Causing Missense Mutations

(2013) Shannon Stefl et al.   JOURNAL OF MOLECULAR BIOLOGY

Predicting disease risks from highly imbalanced data using random forest

(2011) Mohammed Khalilia et al.   BMC Medical Informatics and Decision Making

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

(2011) Isabel Rodríguez-Escudero et al.   HUMAN MOLECULAR GENETICS

Validation of Proposed DSM-5 Criteria for Autism Spectrum Disorder

(2011) Thomas W. Frazier et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands

(2010) Min-Han Tan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly

(2010) Kim L. McBride et al.   Autism Research

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN—Demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN

(2010) Joel Yeong-Chit Chia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Performance of protein stability predictors

(2010) Sofia Khan et al.   HUMAN MUTATION

Accurate prediction of stability changes in protein mutants by combining machine learning with structure based computational mutagenesis

(2008) M. Masso et al.   BIOINFORMATICS

A three-state prediction of single point mutations on protein stability changes

(2008) Emidio Capriotti et al.   BMC BIOINFORMATICS