Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association

Predictor performance with stratified data and imbalanced classes

(2014) Eric A Stone   NATURE METHODS

Structural dynamics flexibility informs function and evolution at a proteome scale

(2013) Zeynep Nevin Gerek et al.   Evolutionary Applications

Prediction of phenotypes of missense mutations in human proteins from biological assemblies

(2013) Qiong Wei et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Protein function and allostery: a dynamic relationship

(2012) Charalampos G. Kalodimos   Annals of the New York Academy of Sciences

Human genomic disease variants: A neutral evolutionary explanation

(2012) J. T. Dudley et al.   GENOME RESEARCH

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Evolutionary diagnosis method for variants in personal exomes

(2012) Sudhir Kumar et al.   NATURE METHODS

Dissipative electro-elastic network model of protein electrostatics

(2012) Daniel R Martin et al.   PHYSICAL BIOLOGY

The interface of protein structure, protein biophysics, and molecular evolution

(2012) David A. Liberles et al.   PROTEIN SCIENCE

Collective Dynamics Differentiates Functional Divergence in Protein Evolution

(2012) Tyler J. Glembo et al.   PLoS Computational Biology

Predicting disease-associated substitution of a single amino acid by analyzing residue interactions

(2011) Yizhou Li et al.   BMC BIOINFORMATICS

Protein-protein interaction sites are hot spots for disease-associated nonsynonymous SNPs

(2011) Alessia David et al.   HUMAN MUTATION

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations

(2011) Sudhir Kumar et al.   TRENDS IN GENETICS

Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

(2011) Z. Nevin Gerek et al.   PLoS Computational Biology

Global Dynamics of Proteins: Bridging Between Structure and Function

(2010) Ivet Bahar et al.   Annual Review of Biophysics

Using bioinformatics to predict the functional impact of SNVs

(2010) M. S. Cline et al.   BIOINFORMATICS

Human allelic variation: perspective from protein function, structure, and evolution

(2010) Daniel M Jordan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Analysis and Prediction of the Metabolic Stability of Proteins Based on Their Sequential Features, Subcellular Locations and Interaction Networks

(2010) Tao Huang et al.   PLoS One

Prediction of Deleterious Non-Synonymous SNPs Based on Protein Interaction Network and Hybrid Properties

(2010) Tao Huang et al.   PLoS One

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs

(2010) Ying Liu et al.   PLoS Computational Biology

Positional conservation and amino acids shape the correct diagnosis and population frequencies of benign and damaging personal amino acid mutations

(2009) S. Kumar et al.   GENOME RESEARCH

Structural Determinants of Protein Evolution Are Context-Sensitive at the Residue Level

(2009) E. A. Franzosa et al.   MOLECULAR BIOLOGY AND EVOLUTION

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

(2009) C. J. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A perturbative view of protein structural variation

(2009) Julián Echave et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Comparison of molecular dynamics and superfamily spaces of protein domain deformation

(2009) Javier A Velazquez-Muriel et al.   BMC STRUCTURAL BIOLOGY

Evolutionary divergence of protein structure: The linearly forced elastic network model

(2008) Julián Echave   CHEMICAL PHYSICS LETTERS

Prediction by Graph Theoretic Measures of Structural Effects in Proteins Arising from Non-Synonymous Single Nucleotide Polymorphisms

(2008) Tammy M. K. Cheng et al.   PLoS Computational Biology