Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Review
Biochemistry & Molecular Biology
Veronica Marrella, Amanda Facoetti, Barbara Cassani
Summary: Cellular senescence is an irreversible cell cycle arrest and inflammatory secretion phenomenon that affects various tissues, including lymphoid tissue, leading to chronic inflammation and immune dysfunction. Persistent microbial challenge or pathogenic microorganisms may accelerate cellular aging and premature senescence of immune cells. Therapeutic strategies targeting cellular senescence may improve immune dysfunctions in the elderly and reduce susceptibility to infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Katarzyna Malgorzata Kwiatkowska, Eleni Mavrogonatou, Adamantia Papadopoulou, Claudia Sala, Luciano Calzari, Davide Gentilini, Maria Giulia Bacalini, Daniele Dall'Olio, Gastone Castellani, Francesco Ravaioli, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Dimitris Kletsas
Summary: The aim of this study was to characterize DNA methylation patterns in replicative and induced senescence in different human cell types. Three epigenetic signatures were identified: cell type- and treatment-specific signature, cell type-specific senescence-related signature, and cell type-transversal replicative senescence-related signature. Cluster analysis revealed distinct DNA methylation patterns in replicative senescent cells, and enrichment in pathways related to the nervous system was shown. Despite no statistically significant evidence of age acceleration, a trend of increased biological age in replicative senescent cultures of all three cell types was observed. This work highlights the heterogeneity of senescent cells and their impact on tissue homeostasis.
Article
Biochemistry & Molecular Biology
Jae-Hyun Yang, Motoshi Hayano, Patrick T. Griffin, Joao A. Amorim, Michael S. Bonkowski, John K. Apostolides, Elias L. Salfati, Marco Blanchette, Elizabeth M. Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M. Ross, Giuseppe Coppotelli, Margarita V. Meer, Ryan Rogers-Hammond, Daniel L. Vera, Yuancheng Ryan Lu, Jeffrey W. Pippin, Michael L. Creswell, Zhixun Dou, Caiyue Xu, Sarah J. Mitchell, Abhirup Das, Brendan L. O'Connell, Sachin Thakur, Alice E. Kane, Qiao Su, Yasuaki Mohri, Emi K. Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A. Rego, Meredith Gregory-Ksander, Tatjana C. Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J. Wagers, Kazuo Tsubota, Stephen J. Bonasera, Carlos M. Palmeira, Jonathan G. Seidman, Christine E. Seidman, Norman S. Wolf, Jill A. Kreiling, John M. Sedivy, George F. Murphy, Richard E. Green, Benjamin A. Garcia, Shelley L. Berger, Philipp Oberdoerffer, Stuart J. Shankland, Vadim N. Gladyshev, Bruce R. Ksander, Andreas R. Pfenning, Luis A. Rajman, David A. Sinclair
Summary: All living things experience increased entropy, resulting in the loss of genetic and epigenetic information. In yeast, this loss occurs due to the relocation of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity and age. Through the ICE system, it is found that faithful DNA repair accelerates aging at multiple levels, including the erosion of the epigenetic landscape and DNA methylation. However, this aging process can be reversed by OSK-mediated rejuvenation, supporting the information theory of aging.
Article
Cell Biology
Claudia Magrin, Martina Bellafante, Martina Sola, Ester Piovesana, Marco Bolis, Luciano Cascione, Sara Napoli, Andrea Rinaldi, Stephanie Papin, Paolo Paganetti
Summary: In this study, we performed a bioinformatics analysis to better understand the possible role of Tau in regulation of chromatin compaction and gene expression. Our findings suggest that Tau depletion leads to deregulation of transcripts involved in the polycomb repressive complex 2, leading to decreased levels of core components of the complex and lower histone 3 trimethylation. These changes are associated with increased senescence induction in Tau-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuna Kim, Hyanggi Ji, Eunae Cho, Nok-Hyun Park, Kyeonghwan Hwang, Wonseok Park, Kwang-Soo Lee, Deokhoon Park, Eunsun Jung
Summary: Functional studies have shown that epigenetic changes can impact aging significantly. Non-coding RNA nc886 plays a key role in cellular senescence, with decreased expression associated with aging and potential for suppression of senescence. AbsoluTea Concentrate 2.0 (ATC) can increase nc886 expression and inhibit cellular senescence by targeting age-related biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, Jean E. Schaffer
Summary: The study identified SNORA73 as a protective factor against lipotoxicity and oxidative stress, showing that its deficiency leads to metabolic reprogramming and protection against steatohepatitis in mice. Specifically, disruption of SNORA73 causes resistance to lipid-induced cell death and oxidative stress in cultured cells, with knockdown of SNORA73 in vivo protecting against hepatic steatosis and lipid-induced oxidative stress and inflammation. This demonstrates a role for SNORA73 in regulating metabolism and lipotoxicity.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Stephanie St-Jean, Ariane Cristina De Castro, Mia Lecours, Christine Jones, Nathalie Rivard, Francis Rodier, Nathalie Perreault, Francois Boudreau
Summary: NCOR1 is essential for colorectal cancer cell growth, and its depletion leads to cellular senescence. Transcriptomic signatures confirm this and predict a potential pro-invasive phenotype. It plays a novel role in preventing cancer-associated senescence and could be a target for controlling colon cancer progression.
Article
Fisheries
Rahul Krishnan, Yo-Seb Jang, Jong -Oh Kim, Su-Young Yoon, Rahul Rajendran, Myung-Joo Oh
Summary: Changes in fish's thermal optima affect their physiology and immune response. Optimal temperature induces immune priming, while suboptimal temperature leads to trained immunity through epigenetic control.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biology
Woei-Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada
Summary: The study explores the unique mechanisms of cholesterol metabolism in naked mole-rat cells, which may contribute to their anti-senescent properties and longevity. Beta-catenin is identified as a key player in regulating cholesterol metabolism to offset senescence in naked mole-rats.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Heng Jiang, Hao Chen, Yao Wang, Yeben Qian, Pierluigi Toniutto, Kelvin K. Ng
Summary: This study investigated the heterogeneity of cuproptosis in patients with hepatocellular carcinoma (HCC) using publicly available databases and bioinformatics tools. The results revealed the existence of three HCC subtypes with differences in survival outcomes, genomic instability, senescence environment, and response to anticancer drugs. Three cuproptosis-related genes were identified, which could be used to design personalized therapeutic strategies for HCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Yan Wang, Jianji Gao, Fan Wu, Caiyun Lai, Yueqi Li, Gaoqiang Zhang, Xinyue Peng, Susu Yu, Jiani Yang, Wei Wang, Wenjuan Zhang, Xingfen Yang
Summary: The study revealed that in the senescence process of human embryonic lung fibroblasts, mitochondrial quantity decreased, mtDNA copy number increased, methyltransferases activity heightened, and acute ROS accumulation triggered premature senescence. In persistent premature senescence, ATP levels and mt-5-mC were higher than in replicative senescence, while 8-OHdG levels were lower. Alterations in mitochondrial biological functions and mtDNA features may serve as novel biomarkers for cellular senescence.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Carly A. Bobak, Abhimanyu, Harini Natarajan, Tanmay Gandhi, Sandra L. Grimm, Tomoki Nishiguchi, Kent Koster, Santiago Carrero Longlax, Qiniso Dlamini, Jacquiline Kahari, Godwin Mtetwa, Jeffrey D. Cirillo, James O'Malley, Jane E. Hill, Cristian Coarfa, Andrew R. DiNardo
Summary: The study found that tuberculosis disrupts epigenetic processes, promoting cellular aging and inflammation, which may explain the long-term detrimental health outcomes after tuberculosis.
Article
Neurosciences
Yonghe Hu, Xinxin Shen, Feifan Liu, Weiguo Zhu
Summary: Morphine dependence can lead to neurodegenerative disorders, but this study suggests that phoenixin-14 may have a beneficial effect against morphine-induced cellular senescence by regulating YAP expression.
NEUROTOXICITY RESEARCH
(2022)
Article
Oncology
Hua You, Zijun Y. Xu-Monette, Li Wei, Harry Nunns, Mate L. Nagy, Govind Bhagat, Xiaosheng Fang, Feng Zhu, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Fredrick B. Hagemeister, Jooryung Huh, Maurilio Ponzoni, Andres J. M. Ferreri, Michael B. Moller, Benjamin M. Parsons, J. Han Van Krieken, Miguel A. Piris, Jane N. Winter, Yong Li, Qingyan Au, Bing Xu, Maher Albitar, Ken H. Young
Summary: The study identified the associations of KMT2D and TP53 mutations with increased mutation numbers in DLBCL, and the poor clinical outcomes associated with high mutation numbers. The underlying mechanisms were revealed through gene-expression profiling and the correlation of MUThigh with decreased T cells in patients with DLBCL. Furthermore, MUThigh was linked to lower PD-1 and PD-L1 expression, suggesting a potential positive impact on immune responses in DLBCL patients.
Editorial Material
Biochemistry & Molecular Biology
Luisa Tasselli, Katrin F. Chua
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
M. Marchesini, R. Matocci, L. Tasselli, V. Cambiaghi, A. Orleth, L. Furia, C. Marinelli, S. Lombardi, G. Sammarelli, F. Aversa, S. Minucci, M. Faretta, P. G. Pelicci, F. Grignani
Editorial Material
Biochemistry & Molecular Biology
Luisa Tasselli, Katrin F. Chua
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Luisa Tasselli, Yuanxin Xi, Wei Zheng, Ruth I. Tennen, Zaneta Odrowaz, Federica Simeoni, Wei Li, Katrin F. Chua
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Correction
Biochemistry & Molecular Biology
M. Marchesini, R. Matocci, L. Tasselli, V. Cambiaghi, A. Orleth, L. Furia, C. Marinelli, S. Lombardi, G. Sammarelli, F. Aversa, S. Minucci, M. Faretta, P. G. Pelicci, F. Grignani
Article
Biochemistry & Molecular Biology
Luisa Tasselli, Yuanxin Xi, Wei Zheng, Ruth I. Tennen, Zaneta Odrowaz, Federica Simeoni, Wei Li, Katrin F. Chua
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2016)
Review
Endocrinology & Metabolism
Luisa Tasselli, Wei Zheng, Katrin F. Chua
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2017)
Editorial Material
Multidisciplinary Sciences
Luisa Tasselli, Katrin F. Chua
Article
Multidisciplinary Sciences
Matthew F. Barber, Eriko Michishita-Kioi, Yuanxin Xi, Luisa Tasselli, Mitomu Kioi, Zarmik Moqtaderi, Ruth I. Tennen, Silvana Paredes, Nicolas L. Young, Kaifu Chen, Kevin Struhl, Benjamin A. Garcia, Or Gozani, Wei Li, Katrin F. Chua
Article
Multidisciplinary Sciences
Federica Simeoni, Luisa Tasselli, Shinji Tanaka, Lidia Villanova, Mayumi Hayashi, Kazuishi Kubota, Fujio Isono, Benjamin A. Garcia, Eriko Michishita-Kioi, Katrin F. Chua
SCIENTIFIC REPORTS
(2013)
Article
Genetics & Heredity
Wei Zheng, Luisa Tasselli, Tie-mei Li, Katrin F. Chua
Summary: The modulation of dynamic histone acetylation states is crucial for gene expression and chromatin structure. SIRT6 controls nuclear levels of ACLY and regulates the expression of tumor suppressive genes by affecting nuclear acetyl-CoA pools.
Article
Oncology
Alessandra Venanzi, Andrea Marra, Gianluca Schiavoni, Sara G. Milner, Roberto Limongello, Alessia Santi, Valentina Pettirossi, Simona Ultimo, Luisa Tasselli, Alessandra Pucciarini, Lorenza Falini, Sofia Sciabolacci, Maria Paola Martelli, Paolo Sportoletti, Stefano Ascani, Brunangelo Falini, Enrico Tiacci
Summary: The study found that clonal hematopoiesis could be present in the tissue of classic Hodgkin lymphoma (cHL), give rise to the tumor clone, and spread to large parts of its microenvironment. Even when massive, clonal hematopoiesis does not always lead to the neoplastic clone of multiple myeloid and lymphoid neoplasms occurring in the same patient.
BLOOD CANCER DISCOVERY
(2021)