Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

Inhibition of Heat Shock Protein 90 Prevents HIV Rebound

(2016) Pheroze Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent developments in the effort to cure HIV infection: going beyond N = 1

(2016) Janet D. Siliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Heptad-Specific Phosphorylation of RNA Polymerase II CTD

(2016) Roland Schüller et al.   MOLECULAR CELL

Direct Analysis of Phosphorylation Sites on the Rpb1 C-Terminal Domain of RNA Polymerase II

(2016) Hyunsuk Suh et al.   MOLECULAR CELL

An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb

(2016) Lydia Kobbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

(2016) Ursula Schulze-Gahmen et al.   eLife

PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation

(2015) Swapna Aravind Gudipaty et al.   MOLECULAR AND CELLULAR BIOLOGY

THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing

(2015) Kyle A. Nilson et al.   MOLECULAR CELL

Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression

(2015) Uri R. Mbonye et al.   PROTEOMICS

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

(2014) J. K. Jadlowsky et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

(2013) Ryan P. McNamara et al.   Cell Reports

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

(2013) Uri R. Mbonye et al.   PLoS Pathogens

Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+ T Cells

(2012) S. Budhiraja et al.   JOURNAL OF VIROLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

(2012) Koh Fujinaga et al.   NUCLEIC ACIDS RESEARCH

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4+ T cells and inhibits HIV-1 gene expression

(2012) Sona Budhiraja et al.   Retrovirology

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway

(2011) Rajesh Ramakrishnan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

(2011) Young Kyeung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes

(2011) K. Chiang et al.   JOURNAL OF VIROLOGY

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

(2011) Tatiana Ammosova et al.   PLoS One

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrestin Vivo

(2010) Bonnie Tillotson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription

(2010) Tatiana Ammosova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Organization and Dynamics of 7SK RNA in Regulating Gene Expression

(2010) Kannanganattu V. Prasanth et al.   MOLECULAR BIOLOGY OF THE CELL

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK

(2010) Brian J. Krueger et al.   PLoS One

Geldanamycin and its anti-cancer activities

(2009) Yayoi Fukuyo et al.   CANCER LETTERS

Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes

(2009) Rajesh Ramakrishnan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evolution of 7SK RNA and Its Protein Partners in Metazoa

(2009) M. Marz et al.   MOLECULAR BIOLOGY AND EVOLUTION

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY