Structure-guided design and functional characterization of an artificial red light–regulated guanylate/adenylate cyclase for optogenetic applications

Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases

(2017) Miriam Ziegler et al.   FEBS Journal

Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

(2017) Robert Lindner et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation

(2017) Irene Vercellino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of transmembrane signaling by sensor histidine kinases

(2017) Ivan Gushchin et al.   SCIENCE

Coiled Coils – A Model System for the 21st Century

(2017) Andrei N. Lupas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

(2017) Matthew A Churgin et al.   eLife

Long-range allosteric signaling in red light–regulated diguanylyl cyclases

(2017) Geoffrey Gourinchas et al.   Science Advances

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site

(2016) Silke Kleinboelting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase

(2016) Lavoisier Ramos-Espiritu et al.   Nature Chemical Biology

Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium

(2016) Mio Ohki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Deinococcus Phytochrome in the Photoactivated State Reveals a Cascade of Structural Rearrangements during Photoconversion

(2016) E. Sethe Burgie et al.   STRUCTURE

Status of the crystallography beamlines at PETRA III

(2016) Anja Burkhardt et al.   European Physical Journal Plus

Structural photoactivation of a full-length bacterial phytochrome

(2016) A. Bjo rling et al.   Science Advances

Natural Photoreceptors as a Source of Fluorescent Proteins, Biosensors, and Optogenetic Tools

(2015) Daria M. Shcherbakova et al.   Annual Review of Biochemistry

Signal Transduction in Histidine Kinases: Insights from New Structures

(2015) Manasi P. Bhate et al.   STRUCTURE

Structural Details of Light Activation of the LOV2-based Photoswitch PA-Rac1

(2014) Andreas Winkler et al.   ACS Chemical Biology

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

(2014) Susanne M. Saalau-Bethell et al.   ChemMedChem

Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes - implications for cyclase catalysis and evolution

(2014) Silke Kleinboelting et al.   FEBS Journal

Crystallographic and Electron Microscopic Analyses of a Bacterial Phytochrome Reveal Local and Global Rearrangements during Photoconversion

(2014) E. Sethe Burgie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyanobacteriochrome SesA Is a Diguanylate Cyclase That Induces Cell Aggregation inThermosynechococcus

(2014) Gen Enomoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexicon 2: Automated Processing of Hydrogen-Deuterium Exchange Mass Spectrometry Data with Improved Deuteration Distribution Estimation

(2014) Robert Lindner et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Signal amplification and transduction in phytochrome photosensors

(2014) Heikki Takala et al.   NATURE

Illuminating cell signalling with optogenetic tools

(2014) Doug Tischer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Engineering adenylate cyclases regulated by near-infrared window light

(2014) M.-H. Ryu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

(2014) S. Kleinboelting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase

(2014) C. Gasser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Codon adaptation–based control of protein expression in C. elegans

(2011) Stefanie Redemann et al.   NATURE METHODS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

Design and Signaling Mechanism of Light-Regulated Histidine Kinases

(2008) Andreas Möglich et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of the guanylyl cyclase Cya2

(2008) A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA