The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

(2016) Matthias R. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

(2015) Masatsugu Hiraki et al.   CHEMISTRY & BIOLOGY

Regulation of glucose metabolism by p53: Emerging new roles for the tumor suppressor

(2015) Esha Madan et al.   Oncotarget

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer

(2014) Kellie S. Rath et al.   CANCER RESEARCH

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118acetylation

(2013) Rajan Gogna et al.   EMBO Molecular Medicine

SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1-Trx Complex

(2013) E. Madan et al.   MOLECULAR AND CELLULAR BIOLOGY

Preferential Binding of Hot Spot Mutant p53 Proteins to Supercoiled DNA In Vitro and in Cells

(2013) Marie Brázdová et al.   PLoS One

A p38mapk-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells

(2013) Y Hadjal et al.   Cell Death & Disease

The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis

(2013) P. Yang et al.   Scientific Reports

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

p53 Ser15phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

(2012) Esha Madan et al.   BIOCHEMICAL JOURNAL

TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

(2012) E Madan et al.   BRITISH JOURNAL OF CANCER

HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells

(2012) Brent J. Tierney et al.   CANCER BIOLOGY & THERAPY

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

Targeting Mutant p53 in Human Tumors

(2012) Brian D. Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

(2012) Rainer Wilcken et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications

(2012) R Gogna et al.   Cell Death & Disease

Chaperoning of Mutant p53 Protein by Wild-type p53 Protein Causes Hypoxic Tumor Regression

(2011) Rajan Gogna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia

(2011) Martin Trbusek et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated p53 Tetramerization Domain Mutants

(2010) Rui Kamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered-Function p53 Missense Mutations Identified in Breast Cancers Can Have Subtle Effects on Transactivation

(2010) Jennifer J. Jordan et al.   MOLECULAR CANCER RESEARCH

HO-3867, a Synthetic Compound, Inhibits the Migration and Invasion of Ovarian Carcinoma Cells through Downregulation of Fatty Acid Synthase and Focal Adhesion Kinase

(2010) K. Selvendiran et al.   MOLECULAR CANCER RESEARCH

Anticancer Efficacy of a Difluorodiarylidenyl Piperidone (HO-3867) in Human Ovarian Cancer Cells and Tumor Xenografts

(2010) K. Selvendiran et al.   MOLECULAR CANCER THERAPEUTICS

Mutant p53 mediates survival of breast cancer cells

(2009) L Y Lim et al.   BRITISH JOURNAL OF CANCER

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions

(2009) D Walerych et al.   ONCOGENE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA