Article
Fisheries
Xiuqin Tang, Meijun Yang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv, Huihui Liu
Summary: A novel isoform of MyD88, NaMyD88, was identified and functionally characterized in Nibea albiflora. This protein shared high identity with known MyD88 and was found to interact with NaTLR9 in the cytoplasm. Expression of NaMyD88 was detected in various tissues and up-regulated after infection, indicating its involvement in the immune response of N.albiflora.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Shaoshuai Tang, Xinlan Xu, Dapeng Yu, Meng Long, Hongli Xia, Yishan Lu, Zhen Gan
Summary: This study characterizes the immune functions of amphibian MyD88 and reveals the functional conservation of MyD88 in early tetrapods.
Review
Biochemistry & Molecular Biology
Hammad Ahmed, Mahtab Ahmad Khan, Ulf Dietrich Kahlert, Mika Niemela, Daniel Haenggi, Shafqat Rasul Chaudhry, Sajjad Muhammad
Summary: MyD88 is an inflammatory adaptor protein in the Toll-like receptor 4 signaling pathway, playing a crucial role in SAH-related neuroinflammation. Research suggests that inhibition of MyD88 can reduce inflammation caused by SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Xiaoting Gong, Min Li, Lili Zhang, Shiyu Huang, Guodong Wang
Summary: In this study, the MyD88 gene from Haliotis diversicolor was identified and its expression patterns during early embryonic development were analyzed. The results showed that MyD88 exhibited constitutive expression throughout all developmental stages, with the highest expression level at the 8 cell stage. Furthermore, knockdown of MyD88 resulted in a significant decrease in its expression, indicating its importance in the early innate immunity of abalone larvae.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Meike von Wulffen, Veronika Luehrmann, Stefanie Robeck, Antonella Russo, Lena Fischer-Riepe, Martijn van den Bosch, Peter van Lent, Karin Loser, Dmitry I. Gabrilovich, Sven Hermann, Johannes Roth, Thomas Vogl
Summary: This study demonstrates the crucial role of endogenous alarmin S100A8/A9 in autoimmune arthritis by reprogramming myeloid cells to a T cell suppressing phenotype. The reprogramming process is dependent on Toll-like receptor 4.
Article
Hematology
Wanqiao Wang, Xin Li, Xia Qin, Yan Miao, Yingwen Zhang, Shanshan Li, Ruen Yao, Yi Yang, Lisha Yu, Hua Zhu, Lili Song, Shengqiao Mao, Xiumin Wang, Jing Chen, Haizhong Feng, Yanxin Li
Summary: Juvenile myelomonocytic leukaemia (JMML) is a pediatric leukemia characterized by mutations in RAS pathway genes, including NF1 gene, which drive the disease's progression. While germline NF1 mutations primarily cause benign tumors, the underlying mechanism for JMML development remains unclear. This study reveals that reduced NF1 gene dose promotes immune cells in anti-tumor immune response, with NF1 mutations or knockout recapitulating JMML's pathological characteristics. The study also suggests a potential cell immunotherapy for JMML patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Naval Daver, Alexander E. Perl, Joseph Maly, Mark Levis, Ellen Ritchie, Mark Litzow, James McCloskey, Catherine C. Smith, Gary Schiller, Terrence Bradley, Ramon Tiu, Kiran Naqvi, Monique Dail, Deanna Brackman, Satya Siddani, Jing Wang, Brenda Chyla, Paul Lee, Jessica K. Altman
Summary: Combining gilteritinib with venetoclax has shown promising results in treating relapsed/refractory FLT3-mutated AML, with high rates of response and molecular remission regardless of prior FLT3 inhibitor therapy.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jenny Furlanetto, Volker Moebus, Andreas Schneeweiss, Kerstin Rhiem, Hans Tesch, Jens-Uwe Blohmer, Kristina Luebbe, Michael Untch, Christoph Salat, Jens Huober, Peter Klare, Rita Schmutzler, Fergus J. Couch, Bianca Lederer, Bernd Gerber, Dirk-Michael Zahm, Ingo Bauerfeind, Valentina Nekljudova, Claus Hanusch, Christian Jackisch, Theresa Link, Eric Hahnen, Sibylle Loibl, Peter A. Fasching
Summary: The study found that patients with germline BRCA1/2 mutations undergoing standard chemotherapy for early triple-negative breast cancer did not have a higher risk of severe hematological toxicities. However, under treatment with taxanes, patients with BRCA1/2 mutations may have a higher risk of hematological toxicities, suggesting the need for further research.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Immunology
Tengfei Song, Yonghong Yao, Julien Papoin, Barbara Sherry, Betty Diamond, Hua Gu, Lionel Blanc, Yong-Rui Zou
Summary: Infection can enhance myeloid output even after it is cleared, and TIMP1 plays a role in sustaining this effect by suppressing the activation of the Notch signaling pathway.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Yingfen Ying, Jinbin Ye, Yaming Chen, Qishu Chen, Yilu Chen, Xiaosheng Lu, Haitao Xi, Feng Gu, Deng Pan, Junzhao Zhao
Summary: Through clinical and genetic characteristics examination of ELANE mutation in a 3-year-old male, it was found that the mutation was inherited from his father, who had germline mosaicism. The study showed that CRISPR/Cas9-mediated homology-directed repair technology can partially correct the mutation in 293-ELANE cells.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Mingyao Zhou, Wei Yuan, Bing Yang, Wei Pei, Jie Ma, Qiang Feng
Summary: This study investigated the impact of Clostridium butyricum (CB) on colorectal cancer (CRC) and found that CB could restrain the progression of CRC, improve inflammation, alter gut microbiota composition, and regulate related signaling pathways.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Evolutionary Biology
Francesco Catania, Rebecca Rothering, Valerio Vitali
Summary: The study examines somatic genome plasticity in Paramecium tetraurelia through Mutation Accumulation (MA) experiments. Results show that the polyploid somatic genome of P. tetraurelia accrues hundreds of intervening DNA segments (IESs), affecting somatic DNA copies and producing IES excision/retention polymorphisms. These findings suggest a relationship between the organism's high germline DNA replication fidelity and pervasive somatic genome plasticity, highlighting the importance of MA regimes in studying developmental plasticity, somatic mutations, and epimutations in ecology and evolution.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Evolutionary Biology
Francesco Catania, Rebecca Rothering, Valerio Vitali
Summary: MA experiments reveal extraordinary germline genome stability in Paramecium tetraurelia, but the polyploid somatic genome of isogenic P. tetraurelia lines propagated for >40 sexual cycles in nutrient-rich medium accumulated numerous intervening DNA segments (IESs) that exhibit diversity and are epigenetically controlled.
GENOME BIOLOGY AND EVOLUTION
(2021)
Article
Immunology
Amelia C. Trombetta, Guilherme B. Farias, Andre M. C. Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M. Conceicao, Joel Laia, Diana F. Santos, Afonso R. M. Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E. Sousa, Susana M. Fernandes
Summary: This study found that the acquisition of an immune-regulatory myeloid cell phenotype may contribute to recovery in severe COVID-19 patients, and therapeutic agents favoring an innate immune system regulatory shift could be the best strategy at this stage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Miguel Reyes, Michael R. Filbin, Roby P. Bhattacharyya, Abraham Sonny, Arnav Mehta, Kianna Billman, Kyle R. Kays, Mayra Pinilla-Vera, Maura E. Benson, Lisa A. Cosimi, Deborah T. Hung, Bruce D. Levy, Alexandra-Chloe Villani, Moshe Sade-Feldman, Rebecca M. Baron, Marcia B. Goldberg, Paul C. Blainey, Nir Hacohen
Summary: The study found an expanded CD14(+) monocyte state, MS1, in patients with bacterial sepsis and severe COVID-19, with the gene expression program of MS1 correlating with sepsis severity and being up-regulated in monocytes from severe COVID-19 patients. In vitro induction of MS1 cells from healthy bone marrow HSPCs showed that plasma from sepsis or COVID-19 patients could induce myelopoiesis and expression of the MS1 gene program. The study also demonstrated that systemic cytokines such as IL-6 and IL-10 played a role in inducing myelopoiesis during severe bacterial or SARS-CoV-2 infection.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
