Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection

Endothelial dysfunction and immunothrombosis in sepsis

(2023) Eleni Maneta et al.   Frontiers in Immunology

Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors

(2022) Fabian Klein et al.   NATURE IMMUNOLOGY

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

(2021) Siroon Bekkering et al.   Annual Review of Immunology

Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity

(2021) Igor Dolgalev et al.   Frontiers in Cell and Developmental Biology

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

(2021) Francisco Caiado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efferocytosis fuels malignant pleural effusion through TIMP1

(2021) Lilan Zhao et al.   Science Advances

To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis

(2021) Han Leng Ng et al.   Biomolecules

The immunology of sepsis

(2021) Tom van der Poll et al.   IMMUNITY

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

(2020) Antoniana Batsivari et al.   NATURE CELL BIOLOGY

SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders

(2020) Alexander Kaiser et al.   LEUKEMIA

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

(2020) Simone J.C.F.M. Moorlag et al.   Cell Reports

Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding

(2020) Weike Pei et al.   Cell Stem Cell

Hematopoietic Stem Cell Metabolism during Development and Aging

(2020) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL CELL

Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

(2020) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

(2020) Ilaria Guccini et al.   CANCER CELL

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

(2019) Joachim L. Schultze et al.   IMMUNITY

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

The bone marrow microenvironment at single-cell resolution

(2019) Anastasia N. Tikhonova et al.   NATURE

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

(2019) Triantafyllos Chavakis et al.   NATURE IMMUNOLOGY

Infiltrating CCR2+ monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1

(2019) Naoki Kuroda et al.   Scientific Reports

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections

(2019) Eleonora Ciarlo et al.   JOURNAL OF INFECTIOUS DISEASES

Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization

(2019) Chiara Baccin et al.   NATURE CELL BIOLOGY

Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation

(2019) Patrick M. Helbling et al.   Cell Reports

Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis

(2018) Tomohiko Ishibashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis

(2018) Sara Duarte et al.   BLOOD

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Clonal analysis of lineage fate in native haematopoiesis

(2018) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Metabolism as master of hematopoietic stem cell fate

(2018) Kyoko Ito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

(2016) Asuka Terashima et al.   IMMUNITY

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

(2016) Nicola Vannini et al.   Nature Communications

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice

(2015) J. Kobuch et al.   HAEMATOLOGICA

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice

(2015) J. Kobuch et al.   HAEMATOLOGICA

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Association of Sepsis-Related Mortality with Early Increase of TIMP-1/MMP-9 Ratio

(2014) Leonardo Lorente et al.   PLoS One

The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice

(2013) H. Niu et al.   BLOOD

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

The Satb1 Protein Directs Hematopoietic Stem Cell Differentiation toward Lymphoid Lineages

(2013) Yusuke Satoh et al.   IMMUNITY

Animal models of sepsis

(2013) Mitchell P Fink   Virulence

Hematopoietic stem cells: to be or Notch to be

(2012) A. Bigas et al.   BLOOD

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs

(2011) L. Rossi et al.   BLOOD

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

(2011) M. Yoda et al.   BLOOD

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

(2011) Barbara Varnum-Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory signals regulate hematopoietic stem cells

(2011) Megan T. Baldridge et al.   TRENDS IN IMMUNOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

(2008) L. Tian et al.   INTERNATIONAL IMMUNOLOGY

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE