Article
Clinical Neurology
Noriaki Sakai, Seiji Nishino
Summary: Wake-promoting agents, such as solriamfetol and modafinil, can be used to manage excessive daytime sleepiness caused by narcolepsy. Both compounds showed potent wake-promoting effects in narcoleptic mice, but only modafinil induced locomotor activity and increased theta oscillation in a dose-dependent manner. Solriamfetol did not exhibit any psychomotor effects or induce anxiety-related behaviors. These findings suggest that solriamfetol is a promising therapeutic option for excessive daytime sleepiness without the negative side effects of modafinil.
Review
Biochemistry & Molecular Biology
Laura Gilardi, Lighea Simona Airo Farulla, Giuseppe Curigliano, Giovanni Corso, Maria Cristina Leonardi, Francesco Ceci
Summary: Invasive lobular cancer (ILC) is the second most common histological type of breast cancer, characterized by infiltrative growth and metastatic spread. FDG-PET/CT is widely used in oncology and breast cancer patient evaluation, but its efficacy in ILCs is considered suboptimal. This review aims to summarize the current literature on the use of FDG-PET/CT in ILC and discuss the potential of non-FDG radiotracers for precision medicine.
Review
Neurosciences
Xiaomin Huang, Yixun Su, Nan Wang, Hui Li, Zhigang Li, Guowei Yin, Hui Chen, Jianqin Niu, Chenju Yi
Summary: Astrocytes play a crucial role in maintaining the normal functions of the Central Nervous System (CNS). During neurodegenerative diseases, alterations in astrocytic connexin expression and function can affect disease progression by impacting neuronal function and survival. Targeting connexins may be a plausible therapeutic strategy for managing these neurodegenerative diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ting-Ting Yang, Feng Qian, Lian Liu, Xiao-Chun Peng, Jiang-Rong Huang, Bo-Xu Ren, Feng-Ru Tang
Summary: The astroglial network formed through gap junctions balanced the concentrations of ions and neurotransmitters around neurons. Dissociated gap junctions can lead to increased connexin hemichannel activity, triggering brain pathophysiological changes. Studies suggest that decreased connexin hemichannel coupling in astrocytes may play a key role in epileptogenesis.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Review
Biochemistry & Molecular Biology
Motohiro Okada, Tomoka Oka, Misaki Nakamoto, Kouji Fukuyama, Takashi Shiroyama
Summary: Mood disorders are still a major concern in global public health, and current pharmacotherapy is not sufficient to improve or prevent these disorders. This review summarizes the effects of antidepressants, mood-stabilising antipsychotics, and anticonvulsants on astroglial connexin, revealing progress in psychopharmacology for establishing a novel treatment strategy for mood disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Article
Biochemistry & Molecular Biology
Ivanka Jimenez-Dinamarca, Rachel Reyes-Lizana, Yordan Lemunao-Inostroza, Kevin Cardenas, Raimundo Castro-Lazo, Francisca Pena, Claudia M. Lucero, Juan Prieto-Villalobos, Mauricio Antonio Retamal, Juan Andres Orellana, Jimmy Stehberg
Summary: GABA plays a crucial role in regulating the excitatory/inhibitory balance in the brain by affecting the activity of neurons and astrocytes through different GABA receptors. This study specifically focuses on how GABA influences astroglial Cx43 hemichannel activity and its release of glutamate and ATP, providing insights into potential mechanisms underlying psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Giselle Cheung, Danijela Bataveljic, Josien Visser, Naresh Kumar, Julien Moulard, Glenn Dallerac, Daria Mozheiko, Astrid Rollenhagen, Pascal Ezan, Cedric Mongin, Oana Chever, Alexis-Pierre Bemelmans, Joachim Luebke, Isabelle Leray, Nathalie Rouach
Summary: The authors present a fluorescent probe that tracks glutamine in live cells and provide direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions. This study uncovers the importance of astroglial glutamine in physiological synaptic activity and memory.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ting Yang, Min-Hong Zou, Qiong Zou, Ju Jiao, Yong Zhang
Summary: In this article, we report a case of sarcomatoid hepatocellular carcinoma that achieved complete remission with PD-1 treatment, providing some assistance for the diagnosis and treatment of this rare subtype.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Medicine, General & Internal
Harim Kim, Girma M. Ayele, Rediet T. Atalay, Siham Hussien, Bereket Tewoldemedhin, Miriam B. Michael
Summary: Narcolepsy is a hypothalamic disorder characterized by sleep-wake disorders. This case report highlights the impact of postural orthostatic tachycardia syndrome (POTS) on the choice of pharmacotherapy for narcolepsy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cell Biology
Giselle Cheung, Oana Chever, Astrid Rollenhagen, Nicole Quenech'du, Pascal Ezan, Joachim H. R. Luebke, Nathalie Rouach
Summary: A study found that Connexin 43 (Cx43) is enriched in astroglial processes and plays a crucial role in synaptic transmission. It was discovered that Cx43 controls synaptic glutamate levels and allows for activity-dependent glutamine release to sustain normal synaptic transmission and cognition. However, its importance in synaptic vesicle release remains unanswered.
Article
Engineering, Biomedical
Xueqi Chen, Sulei Zhang, Jianhua Zhang, Lixin Chen, Rongfu Wang, Yun Zhou
Summary: The study evaluates an optimization approach based on Patlak plot with reduced blood samples for noninvasive quantification of dynamic F-18-FDG PET imaging. The results show that the method is reliable and can potentially be extended to further translational human studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Claudine Regis, Khadija Benali, Francois Rouzet
Summary: Sarcoidosis is a granulomatous disease of unknown origin that affects multiple systems. Diagnosis can be made through histological identification of non-caseous granulomas or a combination of clinical criteria. Treatment is often necessary to alleviate symptoms and prevent permanent organ dysfunction, particularly in cases of cardiac sarcoidosis. FDG-PET/CT and FDG-PET/MR have emerged as important imaging techniques for the diagnosis, staging, and guiding of biopsies in sarcoidosis. These imaging modalities can identify active inflammatory granulomas and serve as prognostic and therapeutic tools. This review highlights the critical roles of hybrid PET imaging in sarcoidosis and discusses potential future developments using other radiotracers and artificial intelligence applications.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yilong Cui, Hiroyuki Neyama, Di Hu, Tianliang Huang, Emi Hayashinaka, Yasuhiro Wada, Yasuyoshi Watanabe
Summary: In this study, several brain regions that are activated in response to mechanical allodynia in neuropathic pain rat models were successfully identified using FDG PET scanning. These regions include the medial prefrontal cortex, primary somatosensory cortex hindlimb region, and the centrolateral thalamic nucleus. Moreover, the brain activity in these regions was positively correlated with behavioral changes related to mechanical allodynia. These findings suggest that FDG PET imaging in neuropathic pain model rats can evaluate regional brain activity encoding the multidimensional aspects of pain, bridging the gap between preclinical and clinical investigations.
Article
Clinical Neurology
Yves Dauvilliers, Isabelle Arnulf, Nancy Foldvary-Schaefer, Anne Marie Morse, Karel Sonka, Michael J. Thorpy, Emmanuel Mignot, Patricia Chandler, Rupa Parvataneni, Jed Black, Amanda Sterkel, Dan Chen, Franck Skobieranda, Richard K. Bogan
Summary: Lower-sodium oxybate has been proven to be a safe and effective treatment for idiopathic hypersomnia.
Article
Environmental Sciences
L. Dufayet, J. Poupon, D. Vodovar, J. Langrand
Summary: Identifying the source of lead is crucial in managing childhood lead poisoning. By comparing lead isotopic ratios between potential sources and the patient's blood sample, the source of poisoning can be determined. This case report describes a 13-year-old girl who had lead poisoning from eating paint chips in her apartment.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Otorhinolaryngology
Magali Labadie, Jules-Antoine Vaucel, Arnaud Courtois, Patrick Nisse, Marion Legeay, Chantal Medernach, Anne-Marie Patat, Katharina Von Fabeck, Jean-Christophe Gallart, Christine Tournoud, Emmanuel Puskarczyk
Summary: This study aimed to identify factors related to esophageal obstruction caused by swallowed button batteries in children. A prospective multicentric observational cohort study called PilBouTox was conducted from June 1, 2016, to May 31, 2018, at French Poison Control Centers. The study included children aged 0-12 years who had swallowed button batteries. The causes of ingestion, clinical manifestations, medical management, and outcomes were recorded. The study found that anorexia, drooling, dyspnea, fever, hemodynamic instability, pallor, and pain were closely related to esophageal impaction with a relative risk greater than 30. Additionally, button batteries larger than 15 mm were associated with esophageal impaction with a relative risk of 19. The absence of initial symptoms was found to be a protective factor against esophageal impaction with a relative risk of 0.013. The study also identified dyspnea, cough, dysphagia, drooling, fever, hemodynamic instability, pain, pallor, and vomiting as symptoms closely related to major effects and death. The rapid recognition of these symptoms can help ensure prompt medical attention. The study recommended performing an X-ray as soon as possible to determine the position of the swallowed button battery.
Letter
Neurosciences
Laurent Seugnet, Christelle Anaclet, Magali Perier, Jean-Francois Ghersi-Egea, Jian-Sheng Lin
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjorn Bjorvatn, Charles M. Morin, Thomas Penzel, Christian Benedict, Adrijana Koscec Bjelajac, Ngan Yin Chan, Colin A. Espie, Harald Hrubos-Strom, Yuichi Inoue, Maria Korman, Anne-Marie Landtblom, Damien Leger, Kentaro Matsui, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Juliana Yordanova, Markku Partinen
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Sofiene Chenini, Anna Laura Rassu, Yves Dauvilliers
Summary: This study evaluated the feasibility, acceptability, and usefulness of home nocturnal infrared video recording in assessing the frequency and complexity of non-rapid eye movement sleep parasomnias in adults, as well as monitoring treatment response.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Anna Laura Rassu, Elisa Evangelista, Sofiene Chenini, Sabine Scholz, Isabelle Jaussent, Yves Dauvilliers
Summary: The study aims to evaluate alternative measures of the multiple sleep latency test (MSLT) for identifying hypocretin-deficiency in patients with hypersomnolence, including narcolepsy patients. The results show that compared to the current neurophysiological standard criteria, alternative MSLT measures are more effective in identifying hypocretin-deficient patients with hypersomnolence and narcolepsy. Daytime REM sleep duration is highlighted as a relevant neurophysiological biomarker of hypocretin-deficiency, which can be used in clinical and research settings.
Article
Clinical Neurology
Dieter Kunz, Yves Dauvilliers, Heike Benes, Diego Garcia-Borreguero, Giuseppe Plazzi, Dalma Seboek Kinter, Preciosa Coloma, Magdalene Rausch, Mouna Sassi-Sayadi, Stephen Thein
Summary: In this 40-week extension study, Daridorexant was found to be safe and well-tolerated for long-term treatment of insomnia disorder. It improved sleep and daytime functioning, with the most pronounced effects observed with the 50 mg dose.
Article
Medicine, General & Internal
Alisa M. Higgins, Lindsay R. Berry, Elizabeth Lorenzi, Srinivas Murthy, Zoe McQuilten, Paul R. Mouncey, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Abi Beane, Wilma Van Bentum-Puijk, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Aiden Burrell, Adrian Buzgau, Meredith Buxton, Walton N. Charles, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Elizabeth O. Fagbodun, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, Christopher M. Horvat, David T. Huang, Nao Ichihara, Francois Lamontagne, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Karen Parry-Billings, Sam E. C. Peters, Luis F. Reyes, Kathryn M. Rowan, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Lucy M. Stronach, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Anthony C. Gordon, Steve A. Webb, Patrick R. Lawler
Summary: The longer-term effects of therapies for critically ill COVID-19 patients are unknown. In this study, 4869 patients were randomized to receive different interventions, and it was found that treatment with IL-6 receptor antagonists and antiplatelet agents significantly improved survival rates after 180 days. These findings suggest that most therapies have consistent effects over a 6-month period.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Marie-Lou Rollin, Regis Lopez, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: One-third of patients with restless legs syndrome reported a decrease in symptoms during cognitive activities, and this improvement was confirmed during a sustained cognitive task.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Critical Care Medicine
Dominique Vodovar, Laurene Dufayet, Bruno Megarbane
AUSTRALIAN CRITICAL CARE
(2023)
Article
Clinical Neurology
Min Zhang, Marine Thieux, Laura Arvis, Jian-Sheng Lin, Aurore Guyon, Sabine Plancoulaine, Carine Villanueva, Patricia Franco
Summary: The prevalence of metabolic syndrome (MS) in children with narcolepsy was investigated, and their clinical and sleep characteristics were evaluated according to different components of MS. It was found that 17.2% of children with narcolepsy had MS, with insulin resistance being the core metabolic disturbance. Children with at least two components of MS had more severe daytime sleepiness and a higher prevalence of night-eating behaviors. Early evaluation and management may be beneficial for these children to prevent future complications.
Article
Clinical Neurology
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J. Thorpy, Anne Marie Morse, Asim Roy, Jordan Dubow, Jennifer Gudeman
Summary: This study evaluated the efficacy of extended-release once-nightly sodium oxybate (ON-SXB; FT218) compared to placebo for daytime sleepiness and disrupted nighttime sleep in narcolepsy type 1 (NT1) and 2 (NT2). The results showed significant improvements in sleep latency, sleep quality, nocturnal arousals, and daytime sleepiness for both NT1 and NT2 subgroups treated with ON-SXB compared to placebo.
Article
Clinical Neurology
Tobias Di Marco, Thomas E. Scammell, Michael Meinel, Dalma Seboek Kinter, Alexandre N. Datta, Gary Zammit, Yves Dauvilliers
Summary: The study aimed to explore the effect of daridorexant, a dual orexin receptor antagonist, on nighttime wake bouts and their correlation with daytime functioning. Results showed that daridorexant reduced the number and duration of long wake bouts during the night compared with placebo, corresponding with improved daytime functioning.
Review
Immunology
Roland S. Liblau, Daniela Latorre, Birgitte R. Kornum, Yves Dauvilliers, Emmanuel J. Mignot
Summary: Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by the loss of certain hypothalamic neurons. It is suspected to have an immune-mediated basis, supported by genetic evidence and increased incidence after vaccination. The search for antigens recognized by pathogenic T cell response in NT1 is ongoing, and animal models provide insights into the roles of autoreactive T cells.
NATURE REVIEWS IMMUNOLOGY
(2023)
