Article
Multidisciplinary Sciences
Saulo Gil, Bruno Gualano, Adriana Ladeira de Araujo, Gersiel Nascimento de Oliveira Junior, Rodolfo Furlan Damiano, Fabio Pinna, Marta Imamura, Vanderson Rocha, Esper Kallas, Linamara Rizzo Batistella, Orestes Forlenza, Carlos R. R. de Carvalho, Geraldo Filho Busatto, Hamilton Roschel
Summary: The aim of this cohort study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. The study found that patients with one or more persistent PASC symptoms have greater odds of being physically inactive than those without any persistent symptoms. Dyspnea, fatigue, insomnia, post-traumatic stress, and severe muscle/joint pain were specifically associated with greater odds of physical inactivity. These findings suggest that PASC is associated with physical inactivity, which may have implications for interventions and patient care.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
Summary: The aim of this study was to investigate the relationship between serum magnesium levels and insomnia and excessive daytime sleepiness (EDS) in older adults. It found that hypomagnesemia was associated with a higher prevalence of EDS but not insomnia in older outpatients. Other health conditions such as hypertension and diabetes mellitus were also more common in the hypomagnesemia group. These findings suggest that hypomagnesemia should be considered when evaluating older adults with EDS.
Article
Clinical Neurology
Elisabetta Fasiello, Samantha Mombelli, Marco Sforza, Marco Zucconi, Francesca Casoni, Konstantina Chadia, Vincenza Castronovo, Paschalis Steiropoulos, Luigi De Gennaro, Luigi Ferini-Strambi, Andrea Galbiati
Summary: The study found that patients with insomnia disorder do not often report sleepiness, indicating an independent relationship between daytime functioning and sleepiness. Cognitive behavioral therapy can improve daytime consequences and fatigue, but it also increases sleepiness. These results suggest that patients with insomnia experience a heightened state of arousal even during wakefulness.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Tomi Sarkanen, Markku Partinen, Bjorn Bjorvatn, Ilona Merikanto, Christian Benedict, Michael R. Nadorff, Courtney J. Bolstad, Colin Espie, Kentaro Matsui, Frances Chung, Charles M. Morin, Yun Kwok Wing, Thomas Penzel, Taina Macedo, Sergio Mota-Rolim, Brigitte Holzinger, Giuseppe Plazzi, Luigi De Gennaro, Anne-Marie Landtblom, Yuichi Inoue, Mariuz Sieminski, Damien Leger, Yves Dauvilliers
Summary: The COVID-19 pandemic and related restriction measures have led to an increase in excessive daytime sleepiness, excessive quantity of sleep, and fatigue. Self-reported cases of COVID-19 are particularly associated with these sleep problems. Shorter sleep duration than desired, depressive symptoms, use of hypnotics, and having reported COVID-19 are strong predictors of excessive daytime sleepiness.
Article
Clinical Neurology
Markku Partinen, Bjorn Bjorvatn, Brigitte Holzinger, Frances Chung, Thomas Penzel, Colin A. Espie, Charles M. Morin
Summary: This international collaboration project aims to investigate the sleep habits and symptoms of adults from different countries during the COVID-19 pandemic. A harmonised questionnaire with multiple languages was developed for anonymous cross-sectional surveys and prospective research.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Zhen-Zhen Liu, Cun-Xian Jia, Xianchen Liu
Summary: The study found that insomnia symptoms and excessive daytime sleepiness were associated with suicidal behavior in adolescents, and excessive daytime sleepiness mediated the link between insomnia symptoms and suicidal behavior.
Review
Medicine, General & Internal
Shiva Rattan Ambardar, Stephanie L. Hightower, Nikhil A. Huprikar, Kevin K. Chung, Anju Singhal, Jacob F. Collen
Summary: This paper explores the long-term respiratory complications of severe COVID-19 infection, highlighting potential risks and discussing strategies for prevention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jacqueline E. Shanley, Andrew F. Valenciano, Garrett Timmons, Annalise E. Miner, Visesha Kakarla, Torge Rempe, Jennifer H. Yang, Amanda Gooding, Marc A. Norman, Sarah J. Banks, Michelle L. Ritter, Ronald J. Ellis, Lucy Horton, Jennifer S. Graves
Summary: This study aimed to assess the initial features and evolution of neurologic Postacute Sequelae of SARS-CoV-2 infection (neuro-PASC). The most common symptoms early in neuro-PASC were fatigue and headaches, while memory impairment and decreased concentration were most prominent at 6 months. Only one-third of participants had complete resolution of neuro-PASC at 6 months, although persistent symptoms showed improvement at follow-up.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Psychology, Social
Joshua Tutek, William K. Wohlgemuth, Kenneth L. Lichstein
Summary: The study investigated whether trait mindfulness predicts daytime impairment caused by poor sleep. Mindfulness was found to have strong negative correlations with nighttime and daytime sleep symptoms.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Biochemistry & Molecular Biology
Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A. Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L. Dai, Priyanka Baloni, Brett Smith, Venkata R. Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A. Algren, William R. Berrington, Julie A. Wallick, Rebecca A. Cochran, Mary E. Micikas, Terri Wrin, Christos J. Petropoulos, Hunter R. Cole, Trevan D. Fischer, Wei Wei, Dave S. B. Hoon, Nathan D. Price, Naeha Subramanian, Joshua A. Hill, Jennifer Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D. Goldman, James R. Heath
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Clinical Neurology
Kalle Johansson, Pontus Wasling, Markus Axelsson
Summary: Fatigue is a prevalent cause of impaired ability to work in patients with multiple sclerosis and narcolepsy. Research indicates that fatigued MS patients resemble narcolepsy patients more than they resemble non-fatigued MS patients, who resemble healthy controls. Insomnia is identified as the main factor associated with fatigue in MS.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Soo Hwan Yim, Jun-Sang Sunwoo, Daeyoung Kim, Min Kyung Chu, Chang-Ho Yun, Kwang Ik Yang
Summary: This study investigated the relationship between fatigue, excessive daytime sleepiness, and depression, finding that both fatigue and excessive daytime sleepiness were associated with depression regardless of the presence of each other.
SLEEP AND BREATHING
(2023)
Article
Multidisciplinary Sciences
Ziyad Al-Aly, Yan Xie, Benjamin Bowe
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Review
Biology
Philipp E. Scherer, John P. Kirwan, Clifford J. Rosen
Summary: Despite efforts to control the SARS-CoV-2 pandemic, a post-COVID-19 syndrome known as long-COVID or Post-Acute Sequelae of CoV-2 (PASC) has emerged. Fatigue, dyspnea, brain fog, and loss of smell and/or taste are common symptoms of this syndrome, which may be associated with metabolic dysfunction and chronic inflammatory state.
Article
Virology
Priya Duggal, Tristan Penson, Hannah N. Manley, Candelaria Vergara, Rebecca M. Munday, Dylan Duchen, Elizabeth A. Linton, Amber Zurn, Jeanne C. Keruly, Shruti H. Mehta, David L. Thomas
Summary: Understanding and describing the symptoms of COVID-19 patients in community settings months after infection, it was found that nearly one-third of the individuals reported incomplete recovery, and a small percentage reported symptoms severe enough to affect daily activities. Those with post-acute sequelae were more likely to have a history of heart attack. Among those with long-term symptoms, men and women were equally represented, but only women reported symptoms that constrained daily activities, with a majority being caregivers. The types of symptoms varied, with many experiencing a deviation from prior COVID-19 health, such as reduced exercise ability, walking ability, concentration, or breathing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Sofiene Chenini, Anna Laura Rassu, Yves Dauvilliers
Summary: This study evaluated the feasibility, acceptability, and usefulness of home nocturnal infrared video recording in assessing the frequency and complexity of non-rapid eye movement sleep parasomnias in adults, as well as monitoring treatment response.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Anesthesiology
Selena Gong, Dorothy Qian, Sheila Riazi, Frances Chung, Marina Englesakis, Qixuan Li, Ella Huszti, Jean Wong
Summary: This systematic review and meta-analysis examined the association between the FRAIL scale and mortality and postoperative outcomes in older surgical patients. The results showed that frailty was associated with 30-day mortality, 6-month mortality, postoperative complications, and postoperative delirium.
ANESTHESIA AND ANALGESIA
(2023)
Article
Clinical Neurology
Serena Scarpelli, Alessandra De Santis, Valentina Alfonsi, Maurizio Gorgoni, Charles M. Morin, Colin Espie, Ilona Merikanto, Frances Chung, Thomas Penzel, Bjorn Bjorvatn, Yves Dauvilliers, Brigitte Holzinger, Yun K. Wing, Markku Partinen, Giuseppe Plazzi, Luigi De Gennaro
Summary: Recent investigations have found that COVID-19 patients may continue to experience symptoms for 2-3 months after the onset of the infection. This study examined sleep and dream alterations in patients with long-COVID and identified the factors that contribute to these alterations. The results showed that long-COVID patients had more severe sleep problems compared to short-COVID patients. Additionally, the number of post-acute symptoms and psychological factors were found to be important determinants of sleep and dream alterations in long-COVID individuals.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Hoi Man Yuen, Kate Ching-ching Chan, Winnie Chiu Wing Chu, Joey W. Y. Chan, Yun Kwok Wing, Albert Martin Li, Chun Ting Au
Summary: This study aimed to examine the craniofacial phenotype of Chinese prepubertal children with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique and to develop a prediction model for OSA diagnosis based on the photogrammetric data. Potential ethnic differences in the association between OSA and photogrammetric data between Chinese and Caucasian children were also examined. The results showed significant differences in craniofacial features between different OSA groups in prepubertal children, and a prediction model based on clinical measurements and photogrammetric features achieved a good performance in OSA diagnosis.
Article
Psychiatry
Pei Xue, Ilona Merikanto, Frances Chung, Charles M. Morin, Colin Espie, Bjorn Bjorvatn, Jonathan Cedernaes, Anne-Marie Landtblom, Thomas Penzel, Luigi De Gennaro, Brigitte Holzinger, Kentaro Matsui, Harald Hrubos-Strom, Maria Korman, Damien Leger, Sergio Mota-Rolim, Courtney J. Bolstad, Michael Nadorff, Giuseppe Plazzi, Catia Reis, Rachel Ngan Yin Chan, Yun Kwok Wing, Juliana Yordanova, Adrijana Koscec Bjelajac, Yuichi Inoue, Markku Partinen, Yves Dauvilliers, Christian Benedict
Summary: Short and long sleep duration after receiving mRNA vaccines is associated with a higher risk of post-COVID symptoms. The study suggests that short and long sleepers are more likely to experience prolonged COVID-19 symptoms compared to normal sleepers. Further research is needed to validate these findings in cohorts with confirmed SARS-CoV-2 infection.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Anna M. Abdollahi, Xinyue Li, Ilona Merikanto, Marja H. Leppanen, Henna Vepsalainen, Reetta Lehto, Carola Ray, Maijaliisa Erkkola, Eva Roos
Summary: This study compared weekday and weekend sleep in relation to weight status among preschool-aged children. Actigraphy measures were more accurate than parent reports. Sleep timing, such as earlier sleep onset and midpoint, was associated with a higher body mass index in children.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, General & Internal
Matthew Weightman, Barbara Robinson, Ricky Fallows, Alasdair L. Henry, Simon D. Kyle, Emma Garratt, Anton Pick, Rachel Teal, Sara Ajina, Nele Demeyere, Colin A. Espie, Ben Seymour, Heidi Johansen-Berg, Melanie K. Fleming
Summary: This trial aims to evaluate the potential of digital cognitive behavioural therapy (dCBT) to improve sleep and rehabilitation outcomes after stroke. The study will randomly allocate participants into either the dCBT intervention group or the control group receiving treatment as usual. The primary outcome will be changes in insomnia symptoms, while secondary outcomes include improvement in overnight motor memory consolidation, sleep measures, and changes in symptoms of depression and fatigue.
Review
Neurosciences
Sara Uccella, Ramona Cordani, Federico Salfi, Maurizio Gorgoni, Serena Scarpelli, Angelo Gemignani, Pierre Alexis Geoffroy, Luigi De Gennaro, Laura Palagini, Michele Ferrara, Lino Nobili
Summary: Sleep patterns change significantly throughout the human lifespan. Adolescents are at high risk for mental health problems due to various physiological and psychosocial changes, including sleep disturbances. Insufficient sleep in adolescents is both a cause and consequence of mental health issues. The recent COVID-19 pandemic has further worsened the mental health and sleep quality of many adolescents. This review aims to summarize the existing knowledge in this field and explore the implications for adolescents' mental and physical health, as well as propose potential prevention strategies.
Article
Health Care Sciences & Services
Lulu Yang, Hongliang Feng, Sizhi Ai, Yue Liu, Binbin Lei, Jie Chen, Xiao Tan, Christian Benedict, Ningjian Wang, Yun Kwok Wing, Lu Qi, Jihui Zhang
Summary: Evidence suggests a potential relationship between circadian rhythm and atrial fibrillation (AF), however, it is largely unknown whether circadian disruption can predict the onset of AF in the general population. This study aimed to investigate the association between accelerometer-measured circadian rest-activity rhythm (CRAR) and the risk of AF, as well as examine the joint associations and potential interactions of CRAR and genetic susceptibility with AF incidence. The results indicate that low amplitude, delayed acrophase, and low mesor are significantly associated with a higher risk of AF.
NPJ DIGITAL MEDICINE
(2023)
Article
Chemistry, Analytical
Gizem Yilmaz, Xingyu Lyu, Ju Lynn Ong, Lieng Hsi Ling, Thomas Penzel, B. T. Thomas Yeo, Michael W. L. Chee
Summary: This study utilized machine learning to predict nocturnal blood pressure using single-channel fingertip plethysmography. The results demonstrated the accuracy of the predictions, highlighting the potential for a cuffless method to continuously monitor blood pressure during sleep.
Article
Clinical Neurology
Tomi Sarkanen, Markku Partinen, Bjorn Bjorvatn, Ilona Merikanto, Christian Benedict, Michael R. Nadorff, Courtney J. Bolstad, Colin Espie, Kentaro Matsui, Frances Chung, Charles M. Morin, Yun Kwok Wing, Thomas Penzel, Taina Macedo, Sergio Mota-Rolim, Brigitte Holzinger, Giuseppe Plazzi, Luigi De Gennaro, Anne-Marie Landtblom, Yuichi Inoue, Mariuz Sieminski, Damien Leger, Yves Dauvilliers
Summary: The COVID-19 pandemic and related restriction measures have led to an increase in excessive daytime sleepiness, excessive quantity of sleep, and fatigue. Self-reported cases of COVID-19 are particularly associated with these sleep problems. Shorter sleep duration than desired, depressive symptoms, use of hypnotics, and having reported COVID-19 are strong predictors of excessive daytime sleepiness.
