Tracking miRNAs' footprints in tumor-microenvironment interactions: Insights and implications for targeted cancer therapy

Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

(2015) Sanyukta Rana et al.   NEOPLASIA

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses

(2014) Xuanming Yang et al.   CANCER CELL

Good things come in small packages: exosomes, immunity and cancer

(2014) W Wang et al.   CANCER GENE THERAPY

MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN

(2014) Ting-Song Yang et al.   FEBS LETTERS

Bevacizumab in combination with fluoropyrimidine-based chemotherapy for the first-line treatment of metastatic colorectal cancer

(2014) S Whyte et al.   HEALTH TECHNOLOGY ASSESSMENT

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31

(2014) Emmanuelle Viré et al.   MOLECULAR CELL

miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization

(2014) Karmele Valencia et al.   Molecular Oncology

Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer

(2014) Maria Angelica Cortez et al.   MOLECULAR THERAPY

Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages

(2014) Fatemeh Momen-Heravi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lessons from miR-143/145: the importance of cell-type localization of miRNAs

(2014) Oliver A. Kent et al.   NUCLEIC ACIDS RESEARCH

Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells

(2014) Jong-Kuen Lee et al.   PLoS One

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

(2014) Fatiha Tabet et al.   Nature Communications

Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

(2014) Catarina Roma-Rodrigues et al.   Biomed Research International

Hypoxia-regulated microRNAs in human cancer

(2013) Guomin Shen et al.   ACTA PHARMACOLOGICA SINICA

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer

(2013) Song Hu et al.   CELL RESEARCH

MiRNA-29: A microRNA Family with Tumor-Suppressing and Immune-Modulating Properties

(2013) M.J. Schmitt et al.   CURRENT MOLECULAR MEDICINE

MicroRNAs in the tumour microenvironment: big role for small players

(2013) Patsy Soon et al.   ENDOCRINE-RELATED CANCER

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain

(2013) L Zeng et al.   GENE THERAPY

Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis

(2013) Xin-Long Yan et al.   HEPATOLOGY

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells

(2013) Hiroko Tadokoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA let-7c Regulates Macrophage Polarization

(2013) S. Banerjee et al.   JOURNAL OF IMMUNOLOGY

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

MicroRNA-148a suppresses the epithelial–mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling

(2013) J-P Zhang et al.   ONCOGENE

MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene

(2013) J Yang et al.   ONCOGENE

Role of Deregulated microRNAs in Breast Cancer Progression Using FFPE Tissue

(2013) Liang Chen et al.   PLoS One

Inhibition of IL-17A in Tumor Microenvironment Augments Cytotoxicity of Tumor-Infiltrating Lymphocytes in Tumor-Bearing Mice

(2013) Keiji Hayata et al.   PLoS One

Expression, Tissue Distribution and Function of miR-21 in Esophageal Squamous Cell Carcinoma

(2013) Nazila Nouraee et al.   PLoS One

Comparisons of microRNA Patterns in Plasma before and after Tumor Removal Reveal New Biomarkers of Lung Squamous Cell Carcinoma

(2013) Vasily N. Aushev et al.   PLoS One

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model

(2013) Jacqueline Banyard et al.   Scientific Reports

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Functional transfer of microRNA by exosomes

(2012) W. Stoorvogel   BLOOD

miR-155 regulates IFN-  production in natural killer cells

(2012) R. Trotta et al.   BLOOD

miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma

(2012) A. L. Kasinski et al.   CANCER RESEARCH

MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

(2012) P. N. Plummer et al.   CANCER RESEARCH

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

TLRs as miRNA Receptors

(2012) M. Fabbri   CANCER RESEARCH

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure

(2012) Philipp Jakob et al.   CIRCULATION

Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters

(2012) N. Nishida et al.   CLINICAL CANCER RESEARCH

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility

(2012) O Aprelikova et al.   ONCOGENE

MicroRNA Signatures in Tumor Tissue Related to Angiogenesis in Non-Small Cell Lung Cancer

(2012) Tom Donnem et al.   PLoS One

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells

(2012) P Kharaziha et al.   Cell Death & Disease

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

(2012) Mario Leonardo Squadrito et al.   Cell Reports

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome

(2011) Z. Zuo et al.   BLOOD

MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A

(2011) C. Urbich et al.   BLOOD

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

CD248 facilitates tumor growth via its cytoplasmic domain

(2011) Margarida Maia et al.   BMC CANCER

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

EMT and Stem Cell-Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells

(2011) C. S. Tellez et al.   CANCER RESEARCH

Cytokines, Inflammation and Colon Cancer

(2011) L. Klampfer   CURRENT CANCER DRUG TARGETS

miR-605joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

(2011) Jiening Xiao et al.   EMBO JOURNAL

Heparin Impairs Angiogenesis through Inhibition of MicroRNA-10b

(2011) Xiaokun Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1  Activity during Prolonged Hypoxia

(2011) U. Bruning et al.   MOLECULAR AND CELLULAR BIOLOGY

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells

(2011) Kim J. Png et al.   NATURE

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

(2011) M Musumeci et al.   ONCOGENE

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

(2011) E. Tili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23 27 24 clusters

(2011) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics

(2011) Guang-Rong Yan et al.   PROTEOMICS

Alterations of MicroRNAs Contribute to Colon Carcinogenesis

(2011) Aaron J. Schetter et al.   SEMINARS IN ONCOLOGY

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Concurrent Suppression of Integrin α5, Radixin, and RhoA Phenocopies the Effects of miR-31 on Metastasis

(2010) Scott Valastyan et al.   CANCER RESEARCH

IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3-Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced Apoptosis

(2010) C. H. Yang et al.   CANCER RESEARCH

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

(2010) Esmerina Tili et al.   CARCINOGENESIS

The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts

(2010) Olga Aprelikova et al.   CELL CYCLE

MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

(2010) S. Hu et al.   CIRCULATION

MicroRNA-151 and its hosting geneFAK(focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma

(2010) Tom Luedde   HEPATOLOGY

Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction

(2010) Qin Yao et al.   INTERNATIONAL JOURNAL OF CANCER

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells

(2010) Yuk Cheung Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-21: an oncomir on strike in prostate cancer

(2010) Marco Folini et al.   Molecular Cancer

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Hypoxia and RAS-signaling pathways converge on and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

(2010) F Loayza-Puch et al.   ONCOGENE

Aberrant MicroRNA-155 Expression Is an Early Event in the Multistep Progression of Pancreatic Adenocarcinoma

(2010) Ji Kon Ryu et al.   PANCREATOLOGY

miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor

(2010) N. E. Renthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation

(2010) Michael C. Schmid et al.   Journal of Oncology

Role of specific microRNAs for endothelial function and angiogenesis

(2009) Fusheng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane Microvesicles as Actors in the Establishment of a Favorable Prostatic Tumoral Niche: A Role for Activated Fibroblasts and CX3CL1-CX3CR1 Axis

(2009) D. Castellana et al.   CANCER RESEARCH

Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma

(2009) A. J. Schetter et al.   CLINICAL CANCER RESEARCH

MicroRNAs: tools for cancer diagnostics

(2009) T Paranjape et al.   GUT

miR-155: On the Crosstalk Between Inflammation and Cancer

(2009) Esmerina Tili et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

(2009) Zhang Lei et al.   PLoS One

A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer

(2009) Merle Hanke et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

(2008) Na Li et al.   CANCER LETTERS

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

Regulation of the Adenomatous Polyposis Coli Gene by the miR-135 Family in Colorectal Cancer

(2008) R. Nagel et al.   CANCER RESEARCH

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

(2008) Kathryn N. Ivey et al.   Cell Stem Cell

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

(2008) Qihong Huang et al.   NATURE CELL BIOLOGY

miR-29 miRNAs activate p53 by targeting p85α and CDC42

(2008) Seong-Yeon Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

(2008) Z Lu et al.   ONCOGENE