The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration

Microglia in steady state

(2017) Katrin Kierdorf et al.   JOURNAL OF CLINICAL INVESTIGATION

Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34 + circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes

(2017) Nermin Kady et al.   Journal of Clinical Lipidology

Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy

(2017) Michelle E. LeBlanc et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization

(2017) Yedi Zhou et al.   Molecular Medicine Reports

Behaviour of CD11b-Positive Cells in an Animal Model of Laser-Induced Choroidal Neovascularisation

(2017) Lu Li et al.   OPHTHALMOLOGICA

Effects of Novel Nitric Oxide-Releasing Molecules against Oxidative Stress on Retinal Pigmented Epithelial Cells

(2017) Valeria Pittalà et al.   Oxidative Medicine and Cellular Longevity

miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions

(2017) Eun-Ah Ye et al.   VISION RESEARCH

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

(2017) Andrew S. Mendiola et al.   Frontiers in Cellular Neuroscience

Microglial Activation in the Pathogenesis of Huntington’s Disease

(2017) Hui-Ming Yang et al.   Frontiers in Aging Neuroscience

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel

(2017) Carl D. Regillo et al.   Ophthalmic Surgery Lasers & Imaging Retina

Modulation of microglia polarization dynamics during diabetic retinopathy in db / db mice

(2016) Ana I. Arroba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Toll-like receptor (TLR)-2/4 expression in retinal ganglion cells in a high-glucose environment and its implications

(2016) M. Zhao et al.   GENETICS AND MOLECULAR RESEARCH

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Endothelial STAT3 Activation Increases Vascular Leakage Through Downregulating Tight Junction Proteins: Implications for Diabetic Retinopathy

(2016) Jang-Hyuk Yun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes

(2016) Eleni Beli et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

(2016) Xu Wang et al.   JOURNAL OF NEUROSCIENCE

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

(2016) Elliott H. Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy

(2016) Harshini Chakravarthy et al.   STEM CELLS

DKK1 inhibits proliferation and migration in human retinal pigment epithelial cells via the Wnt/β-catenin signaling pathway

(2016) Jinzi Zhou et al.   Experimental and Therapeutic Medicine

Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS

(2016) Luciana Frick et al.   Journal of Immunology Research

Nanoparticle-Mediated Expression of a Wnt Pathway Inhibitor Ameliorates Ocular NeovascularizationSignificance

(2015) Zhongxiao Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

(2015) Sandra M. Cardona et al.   ASN Neuro

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Effects of diabetes on retinal pigment epithelial cell proliferation and mitogen-activated protein kinase signaling in dark Agouti rats

(2015) Heba Al-Hussaini et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization

(2015) Sergio Crespo-Garcia et al.   EXPERIMENTAL EYE RESEARCH

A Probable Dual Mode of Action for Both L- and D-Lactate Neuroprotection in Cerebral Ischemia

(2015) Ximena Castillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammatory responses in diabetic retinopathy

(2015) Ying Yu et al.   Journal of Neuroinflammation

Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

(2015) Devy Deliyanti et al.   Journal of Neuroinflammation

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

(2015) James B. Hurley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism

(2015) Mei Du et al.   MOLECULAR AND CELLULAR BIOLOGY

Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease

(2015) Miriam Kolko et al.   NEUROCHEMICAL RESEARCH

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions

(2015) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence

(2015) Rafael Simó et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Association between retinal neuronal degeneration and visual function impairment in type 2 diabetic patients without diabetic retinopathy

(2015) TiePei Zhu et al.   Science China-Life Sciences

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy

(2015) Jianbo He et al.   Journal of Ophthalmology

Diabetic Retinopathy: Vascular and Inflammatory Disease

(2015) F. Semeraro et al.   Journal of Diabetes Research

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration

(2015) Haihan Jiao et al.   PLoS One

Hyperglycemia Induces Toll-Like Receptor-2 and -4 Expression and Activity in Human Microvascular Retinal Endothelial Cells: Implications for Diabetic Retinopathy

(2015) Uthra Rajamani et al.   Journal of Diabetes Research

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy

(2014) Rafael Simó et al.   DIABETES CARE

New treatments for diabetic retinopathy

(2014) A. Das et al.   DIABETES OBESITY & METABOLISM

CD40 promotes the development of early diabetic retinopathy in mice

(2014) Jose-Andres C. Portillo et al.   DIABETOLOGIA

Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy

(2014) F Qiu et al.   EYE

Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Müller cell ablation

(2014) Weiyong Shen et al.   GLIA

Early spatiotemporal characterization of microglial activation in the retinas of rats with streptozotocin-induced diabetes

(2014) Xiaofei Chen et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

(2014) Pierre Bouzat et al.   INTENSIVE CARE MEDICINE

Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina

(2014) M. Wang et al.   JOURNAL OF NEUROSCIENCE

The Role of Inflammation in the Pathogenesis of Macular Edema Secondary to Retinal Vascular Diseases

(2014) Francisco J. Ascaso et al.   MEDIATORS OF INFLAMMATION

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

(2014) Ana R. Santiago et al.   MEDIATORS OF INFLAMMATION

Astrocytic and microglial response in experimentally induced diabetic rat brain

(2014) Aarti Nagayach et al.   METABOLIC BRAIN DISEASE

The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration

(2014) Patricia Bogdanov et al.   PLoS One

High Glucose Alters Retinal Astrocytes Phenotype through Increased Production of Inflammatory Cytokines and Oxidative Stress

(2014) Eui Seok Shin et al.   PLoS One

Effect of Doxycycline vs Placebo on Retinal Function and Diabetic Retinopathy Progression in Patients With Severe Nonproliferative or Non–High-Risk Proliferative Diabetic Retinopathy

(2014) Ingrid U. Scott et al.   JAMA Ophthalmology

Role of phospholipases A2 in diabetic retinopathy: In vitro and in vivo studies

(2013) Gabriella Lupo et al.   BIOCHEMICAL PHARMACOLOGY

Advances in our understanding of diabetic retinopathy

(2013) Alan W. Stitt et al.   CLINICAL SCIENCE

Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases

(2013) Ramya Vadlapatla et al.   CURRENT DRUG TARGETS

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Diabetic Retinopathy and Other Ocular Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

(2013) Lloyd Paul Aiello et al.   DIABETES CARE

Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy

(2013) M.I. Nawaz et al.   EXPERIMENTAL EYE RESEARCH

Microvascular complications and diabetic retinopathy: recent advances and future implications

(2013) Megha Barot et al.   Future Medicinal Chemistry

The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS-stimulated inflammation via enhancement of the platelet-activating factor acetylhydrolase activity in human retinal pigment epithelial cells

(2013) WON-KYO JUNG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury

(2013) Steven F Abcouwer et al.   Journal of Neuroinflammation

Granulocyte macrophage colony-stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of rapamycin-dependent mechanism

(2013) Jacqueline Legacy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuroprotective effects of lactate in brain ischemia: Dependence on anesthetic drugs

(2013) Tobias Horn et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

(2013) Antoine Lampron et al.   NEURON

VEGF Receptor Blockade Markedly Reduces Retinal Microglia/Macrophage Infiltration into Laser-Induced CNV

(2013) Hu Huang et al.   PLoS One

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

(2013) Rafael Simó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Current treatments in diabetic macular oedema: systematic review and meta-analysis

(2013) John Alexander Ford et al.   BMJ Open

Causes of vision loss worldwide, 1990–2010: a systematic analysis

(2013) Rupert R A Bourne et al.   Lancet Global Health

Anti-vascular endothelial growth factor therapy for diabetic macular edema

(2013) David S. Boyer et al.   Therapeutic Advances in Endocrinology and Metabolism

Profile of intraocular tumour necrosis factor-α and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy

(2012) Carin Gustavsson et al.   ACTA OPHTHALMOLOGICA

The role of microglia in the neurogenesis of zebrafish retina

(2012) Tao Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Role of Intravitreal Inflammatory Cytokines and Angiogenic Factors in Proliferative Diabetic Retinopathy

(2012) Jinzi Zhou et al.   CURRENT EYE RESEARCH

Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy

(2012) K. Lee et al.   DIABETES

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

(2012) R. Robinson et al.   Disease Models & Mechanisms

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

(2012) G.N. Costa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy

(2012) Jane Yellowlees Douglas et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The role of microglia in brain maintenance: implications for Rett syndrome

(2012) Noël C. Derecki et al.   TRENDS IN IMMUNOLOGY

Changes in Aqueous Concentrations of Various Cytokines After Intravitreal Triamcinolone Versus Bevacizumab for Diabetic Macular Edema

(2011) Hee Jin Sohn et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Advanced glycation end products and diabetic retinopathy

(2011) Ross Milne et al.   AMINO ACIDS

AGEs, RAGE, and Diabetic Retinopathy

(2011) Hongliang Zong et al.   Current Diabetes Reports

Microvascular Modifications in Diabetic Retinopathy

(2011) Jennifer T. Durham et al.   Current Diabetes Reports

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

(2011) A. S. Ibrahim et al.   DIABETES

Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy

(2011) Carmel M. McVicar et al.   DIABETES

Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy

(2011) M. Tyrberg et al.   DOCUMENTA OPHTHALMOLOGICA

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9

(2011) Ghulam Mohammad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ICAM-1: Getting a Grip on Leukocyte Adhesion

(2011) E. O. Long   JOURNAL OF IMMUNOLOGY

Role of Endothelial Chemokines and Their Receptors during Inflammation

(2011) Cecilia L. Speyer et al.   JOURNAL OF INVESTIGATIVE SURGERY

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

(2011) Minhua Wang et al.   Journal of Neuroinflammation

Identification of a Novel Inhibitor of the Canonical Wnt Pathway

(2011) K. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Inflammation in diabetic retinopathy

(2011) Johnny Tang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Aging increases retinal vascular lesions characteristic of early diabetic retinopathy

(2010) Sumon Roy et al.   BIOGERONTOLOGY

Visual Dysfunction Associated with Diabetic Retinopathy

(2010) Gregory R. Jackson et al.   Current Diabetes Reports

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

Muller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

(2010) J. Wang et al.   DIABETES

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products

(2010) T. M. Curtis et al.   DIABETOLOGIA

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats

(2010) P. Palsamy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction

(2010) Ghulam Mohammad et al.   LABORATORY INVESTIGATION

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Activation of the Wnt Pathway Plays a Pathogenic Role in Diabetic Retinopathy in Humans and Animal Models

(2009) Ying Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy

(2009) M. Garcia-Ramírez et al.   DIABETOLOGIA

Oxidative stress and the development of diabetic retinopathy: Contributory role of matrix metalloproteinase-2

(2009) Renu A. Kowluru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglial response to light-induced photoreceptor degeneration in the mouse retina

(2009) Ana M. Santos et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Active HIF-1 in the Normal Human Retina

(2009) John M. Hughes et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Regulatory SNP in the RBP4 Gene Modified the Expression in Adipocytes and Associated With BMI

(2009) Lkhagvasuren Munkhtulga et al.   Obesity

Diabetic Macular Edema: Pathogenesis and Treatment

(2009) Neelakshi Bhagat et al.   SURVEY OF OPHTHALMOLOGY

Role of Steroids in the Management of Diabetic Macular Edema and Proliferative Diabetic Retinopathy

(2009) Paolo S. Silva et al.   Seminars in Ophthalmology

Diabetes-Enhanced Tumor Necrosis Factor-α Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy

(2008) Yugal Behl et al.   AMERICAN JOURNAL OF PATHOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Microglial Activation in Human Diabetic Retinopathy

(2008) Hui-yang Zeng   ARCHIVES OF OPHTHALMOLOGY

An RBP4 promoter polymorphism increases risk of type 2 diabetes

(2008) M. van Hoek et al.   DIABETOLOGIA

Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients

(2008) Carole Ichai et al.   INTENSIVE CARE MEDICINE

Ex Vivo Dynamic Imaging of Retinal Microglia Using Time-Lapse Confocal Microscopy

(2008) J. E. Lee et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Microglia: gatekeepers of central nervous system immunology

(2008) Bart R. Tambuyzer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Retinal ganglion cells in diabetes

(2008) Timothy S. Kern et al.   JOURNAL OF PHYSIOLOGY-LONDON