The Olive Biophenols Oleuropein and Hydroxytyrosol Selectively Reduce Proliferation, Influence the Cell Cycle, and Induce Apoptosis in Pancreatic Cancer Cells

New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo

(2017) Pinelopi Samara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury

(2017) Fatime Geyikoglu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

(2017) Haseeb Zubair et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A

(2017) Karine Z. Oben et al.   Oncotarget

Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells

(2016) Mücahit Seçme et al.   GENE

Activator protein 1 promotes gemcitabine-induced apoptosis in pancreatic cancer by upregulating its downstream target Bim

(2016) Xiaoxia Ren et al.   Oncology Letters

EGR-1/Bax pathway plays a role in vitamin E δ-tocotrienol-induced apoptosis in pancreatic cancer cells

(2015) Chen Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

(2015) S. Silva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line

(2015) CHUN-MEI YAN et al.   Molecular Medicine Reports

Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells

(2015) Chloe Goldsmith et al.   MOLECULES

Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis

(2015) Ilavarasi Kalaiselvan et al.   PHARMACEUTICAL BIOLOGY

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

(2014) Zeinab Korany Hassan et al.   Asian Pacific Journal of Cancer Prevention

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Nutrient-based dietary patterns and pancreatic cancer risk

(2013) Cristina Bosetti et al.   ANNALS OF EPIDEMIOLOGY

Oleuropein Induces Anti-metastatic Effects in Breast Cancer

(2013) Zeinab K. Hassan et al.   Asian Pacific Journal of Cancer Prevention

The role of Mediterranean diet on the risk of pancreatic cancer

(2013) C Bosetti et al.   BRITISH JOURNAL OF CANCER

The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways

(2013) Izza de Arao Tan et al.   INTERNATIONAL JOURNAL OF CANCER

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells

(2013) Adele Chimento et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein, a Secoiridoid Derived from Olive Tree, Inhibits the Proliferation of Human Colorectal Cancer Cell Through Downregulation of HIF-1α

(2013) Ana Cárdeno et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hydroxytyrosol inhibits cholangiocarcinoma tumor growth: An in vivo and in vitro study

(2013) SHUAI LI et al.   ONCOLOGY REPORTS

Protective role of oleuropein and its metabolite hydroxytyrosol on cancer

(2013) M.P. Carrera-González et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Antiproliferative effect of oleuropein in prostate cell lines

(2012) Luca Vanella   INTERNATIONAL JOURNAL OF ONCOLOGY

The fate of olive fruit phenols during commercial olive oil processing: Traditional press versus continuous two- and three-phase centrifuge

(2012) Tina Jerman Klen et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Chemical and Cellular Antioxidant Activity of Phytochemicals Purified from Olive Mill Waste Waters

(2011) Donato Angelino et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hydroxytyrosol Induces Proliferation and Cytoprotection against Oxidative Injury in Vascular Endothelial Cells: Role of Nrf2 Activation and HO-1 Induction

(2011) Houda Zrelli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

(2010) Eitan Shaulian   CELLULAR SIGNALLING

Regulation of ceramide channels by Bcl-2 family proteins

(2010) Vidyaramanan Ganesan et al.   FEBS LETTERS

Hydroxytyrosol: from laboratory investigations to future clinical trials

(2010) Sergio Granados-Principal et al.   NUTRITION REVIEWS

Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities

(2009) Ok-Hwan Lee et al.   BIORESOURCE TECHNOLOGY

ADAMTS1, a putative anti-angiogenic factor, is decreased in human prostate cancer

(2009) Heléne Gustavsson et al.   BJU INTERNATIONAL

Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice

(2009) Yoshiyuki Kimura et al.   JOURNAL OF NUTRITION

Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells

(2009) Vlassios Goulas et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Aberrant methylation of ADAMTS1 in non-small cell lung cancer

(2008) Jin Eun Choi et al.   CANCER GENETICS AND CYTOGENETICS