Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology

Corticosteroid receptors adopt distinct cyclical transcriptional signatures

(2018) Florian Le Billan et al.   FASEB JOURNAL

Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain

(2018) Karen R. Mifsud et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation

(2018) Judit Bigas et al.   Cell Death & Disease

NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid Receptor DNA Binding in the Male Rat Brain

(2017) Lisa T.C.M. van Weert et al.   ENDOCRINOLOGY

Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants

(2017) Julia Boix et al.   EXPERIMENTAL DERMATOLOGY

Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5

(2017) Andrew P. Sawaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid receptors: finding the middle ground

(2017) Sofie J. Desmet et al.   JOURNAL OF CLINICAL INVESTIGATION

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Coregulators as mediators of mineralocorticoid receptor signalling diversity

(2017) Peter J Fuller et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor

(2017) Stefanie Ruhs et al.   JOURNAL OF ENDOCRINOLOGY

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Evolution of the mineralocorticoid receptor: sequence, structure and function

(2017) Michael E Baker et al.   JOURNAL OF ENDOCRINOLOGY

Stress Signals, Mediated by Membranous Glucocorticoid Receptor, Activate PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure

(2017) Ivan Jozic et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action

(2017) Andrzej T. Slominski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Pathogenic Mechanism of Psoriasis

(2017) Rosalind Hannen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation

(2017) Mrinal K. Sarkar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes

(2017) Julia Boix et al.   Scientific Reports

Glucocorticoid Signaling: An Update from a Genomic Perspective

(2016) Maria A. Sacta et al.   Annual Review of Physiology

Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance

(2016) Nicolas Nicolaides et al.   Hormones-International Journal of Endocrinology and Metabolism

Phosphorylation of Mineralocorticoid Receptor Ligand Binding Domain Impairs Receptor Activation and Has a Dominant Negative Effect over Non-phosphorylated Receptors

(2016) Rubén Jiménez-Canino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local cortisol/corticosterone activation in skin physiology and pathology

(2016) Mika Terao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Epidermal Mineralocorticoid Receptor Plays Beneficial and Adverse Effects in Skin and Mediates Glucocorticoid Responses

(2016) Julia Boix et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism

(2016) Van Tuan Nguyen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic dermatitis

(2016) Stephan Weidinger et al.   LANCET

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases

(2016) Ioanna Petta et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus

(2016) Karen R. Mifsud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

(2016) Diego M. Presman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin steroidogenesis in health and disease

(2016) Georgios Nikolakis et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1

(2016) Elena Carceller et al.   Scientific Reports

A novel actor in skin biology: the mineralocorticoid receptor

(2015) Nicolette Farman et al.   EXPERIMENTAL DERMATOLOGY

The mineralocorticoid receptor plays a transient role in mouse skin development

(2015) Julia Boix et al.   EXPERIMENTAL DERMATOLOGY

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells

(2015) Florian Le Billan et al.   FASEB JOURNAL

GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation

(2015) Sarah A. Jones et al.   JOURNAL OF AUTOIMMUNITY

Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin

(2015) Eve Maubec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glucocorticoid signaling in the heart: A cardiomyocyte perspective

(2015) Robert H. Oakley et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes

(2015) Lisa M. Sevilla et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex

(2015) Guoqiang Hua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Compound A – a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

(2015) Ekaterina Lesovaya et al.   Oncotarget

Genome-wide analysis of murine renal distal convoluted tubular cells for the target genes of mineralocorticoid receptor

(2014) Kohei Ueda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comprehensive Overview of the Structure and Regulation of the Glucocorticoid Receptor

(2014) Sofie Vandevyver et al.   ENDOCRINE REVIEWS

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

(2014) Andrzej T. Slominski et al.   EXPERIMENTAL DERMATOLOGY

Post-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?

(2014) Nourdine Faresse   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner

(2014) Hyun Kyung Yoon et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mammalian skin cell biology: At the interface between laboratory and clinic

(2014) F. M. Watt   SCIENCE

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

(2014) Diego M. Presman et al.   PLOS BIOLOGY

Epithelialization in Wound Healing: A Comprehensive Review

(2014) Irena Pastar et al.   Advances in Wound Care

Cell death by cornification

(2013) Leopold Eckhart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Anti-inflammatory glucocorticoids: Changing concepts

(2013) Robert Newton   EUROPEAN JOURNAL OF PHARMACOLOGY

Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

(2013) Shuang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

(2013) Ana Tiganescu et al.   JOURNAL OF CLINICAL INVESTIGATION

GRowing an Epidermal Tumor

(2013) Wendy B. Bollag et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Selective Ablation of Glucocorticoid Receptor in Mouse Keratinocytes Increases Susceptibility to Skin Tumorigenesis

(2013) Víctor Latorre et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

(2013) Karen Chapman et al.   PHYSIOLOGICAL REVIEWS

Glucocorticoid receptor signaling in health and disease

(2013) Mahita Kadmiel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing

(2013) Jong-Kyung Youm et al.   WOUND REPAIR AND REGENERATION

Aging-like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling

(2012) Takashi Nagase et al.   AGING CELL

The mineralocorticoid signaling pathway throughout development: Expression, regulation and pathophysiological implications

(2012) Laetitia Martinerie et al.   BIOCHIMIE

Nuclear Shuttling Precedes Dimerization in Mineralocorticoid Receptor Signaling

(2012) Claudia Grossmann et al.   CHEMISTRY & BIOLOGY

Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis

(2012) Mayte Suárez-Fariñas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermal Inactivation of the Glucocorticoid Receptor Triggers Skin Barrier Defects and Cutaneous Inflammation

(2012) Lisa M. Sevilla et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

Keratinocyte-Targeted Overexpression of the Glucocorticoid Receptor Delays Cutaneous Wound Healing

(2012) Ana Sanchis et al.   PLoS One

Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function

(2011) Matthew D. Taves et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury

(2011) Sasa Vukelic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratinocytes synthesize and activate cortisol

(2011) Nicola Cirillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis

(2010) Peter M. Elias   Annals of Dermatology

Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

(2010) Ana Tiganescu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glucocorticoid Receptor Regulates Overlapping and Differential Gene Subsets in Developing and Adult Skin

(2010) Lisa M. Sevilla et al.   MOLECULAR ENDOCRINOLOGY

Making an Epidermis

(2009) Maranke I. Koster   Annals of the New York Academy of Sciences

The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

(2009) Nicolette Farman et al.   EXPERIMENTAL DERMATOLOGY

Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

(2009) T. E. Reddy et al.   GENOME RESEARCH

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

Transrepression Function of the Glucocorticoid Receptor Regulates Eyelid Development and Keratinocyte Proliferation but Is Not Sufficient to Prevent Skin Chronic Inflammation

(2008) Eva Donet et al.   MOLECULAR ENDOCRINOLOGY

Glucocorticoid Receptor Is Required for Skin Barrier Competence

(2007) Pilar Bayo et al.   ENDOCRINOLOGY