GDF11 Modulates Ca2+-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy

Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15

(2018) Juli E. Jones et al.   Cell Reports

Transforming growth factor (TGF)-β1 signal pathway: A promising therapeutic target for attenuating cardiac fibrosis

(2017) Jin Xie et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Gdf11/Smad signalling and Cdx proteins cooperate to activate the Hoxc8 early enhancer in HepG2 cells

(2017) Stephen J. Gaunt   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The production of fibroblast growth factor 23 is controlled by TGF-β2

(2017) Martina Feger et al.   Scientific Reports

Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

(2017) Javier Duran et al.   Frontiers in Pharmacology

Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia–reperfusion injury

(2016) Guo-Qing Du et al.   BASIC RESEARCH IN CARDIOLOGY

GDF-15 enhances intracellular Ca2+ by increasing Cav1.3 expression in rat cerebellar granule neurons

(2016) J.-M. Lu et al.   BIOCHEMICAL JOURNAL

GDF11 Inhibits Bone Formation by Activating Smad2/3 in Bone Marrow Mesenchymal Stem Cells

(2016) Qiong Lu et al.   CALCIFIED TISSUE INTERNATIONAL

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

(2016) Marissa J. Schafer et al.   Cell Metabolism

Biochemistry and Biology of GDF11 and MyostatinResponse to Walker et al

(2016) Ryan G. Walker et al.   CIRCULATION RESEARCH

Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy

(2016) Toshimi Tando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GDF11 administration does not extend lifespan in a mouse model of premature aging

(2016) Sandra Freitas-Rodríguez et al.   Oncotarget

GDF11 improves tubular regeneration after acute kidney injury in elderly mice

(2016) Ying Zhang et al.   Scientific Reports

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance

(2015) Tommaso Poggioli et al.   CIRCULATION RESEARCH

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

(2015) Kristoff A. Olson et al.   EUROPEAN HEART JOURNAL

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Transforming Growth Factor–β Evokes Ca2+Waves and Enhances Gene Expression in Human Pulmonary Fibroblasts

(2012) Subhendu Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Calcium Signaling in Cardiac Myocytes

(2011) C. J. Fearnley et al.   Cold Spring Harbor Perspectives in Biology

The IP 3 Receptor Regulates Cardiac Hypertrophy in Response to Select Stimuli

(2010) Hiroyuki Nakayama et al.   CIRCULATION RESEARCH

TGF-β mediates PTEN suppression and cell motility through calcium-dependent PKC-α activation in pancreatic cancer cells

(2008) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY