GDF11 Inhibits Bone Formation by Activating Smad2/3 in Bone Marrow Mesenchymal Stem Cells

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

Growth differentiation factor 11 is a protective factor for osteoblastogenesis by targeting PPARgamma

(2015) Yan Zhang et al.   GENE

S-nitrosoglutathione reductase–dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis

(2015) Yenong Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation

(2015) Chang-Jun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Factors Mediate Reversible Age-Associated Brain Dysfunction

(2014) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

FOXOs attenuate bone formation by suppressing Wnt signaling

(2013) Srividhya Iyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

(2013) Jae-Hyuck Shim et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

(2012) Yanqiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

(2011) Joy Y. Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of vertebral deformities to chronic back pain and disability

(2010) Bruce Ettinger et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation

(2010) Keizo Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra

(2010) Zicong Li et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Cellular mechanisms of bone remodeling

(2010) Erik Fink Eriksen   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Recombinant Myostatin (GDF-8) Propeptide Enhances the Repair and Regeneration of Both Muscle and Bone in a Model of Deep Penetrant Musculoskeletal Injury

(2010) Mark W. Hamrick et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION