Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer

Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion

(2017) Jinlu Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma

(2016) K. Satoh et al.   CLINICAL CANCER RESEARCH

Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family

(2016) Mohammed A. Suliman et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer

(2016) Rebecca C. Arend et al.   Oncotarget

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

Niclosamide Analogs for Treatment of Ovarian Cancer

(2015) Christen L. Walters Haygood et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition

(2015) Chengfei Liu et al.   PROSTATE

A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells

(2015) B Chu et al.   Cell Death & Disease

Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells

(2015) Sylvie Maubant et al.   PLoS One

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer

(2014) Rebecca C. Arend et al.   GYNECOLOGIC ONCOLOGY

Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells

(2014) Bibek Parajuli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Niclosamide on Basal-like Breast Cancers

(2014) A. I. Londono-Joshi et al.   MOLECULAR CANCER THERAPEUTICS

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

(2014) Tinghong Ye et al.   PLoS One

Wnt signaling in triple negative breast cancer is associated with metastasis

(2013) Nandini Dey et al.   BMC CANCER

Therapeutic targets in triple negative breast cancer

(2013) Sandra A O'Toole et al.   JOURNAL OF CLINICAL PATHOLOGY

Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

(2013) Birdal Bilir et al.   Journal of Translational Medicine

Tumor-Initiating Cells and FZD8 Play a Major Role in Drug Resistance in Triple-Negative Breast Cancer

(2013) S. Yin et al.   MOLECULAR CANCER THERAPEUTICS

Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer

(2013) S. You et al.   MOLECULAR CANCER THERAPEUTICS

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells

(2013) Yu-Chi Wang et al.   PLoS One

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

(2013) J. L. Green et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

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6-Nitrobenzimidazole derivatives: Potential phosphodiesterase inhibitors: Synthesis and structure–activity relationship

(2011) K.M. Khan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

(2011) T. Osada et al.   CANCER RESEARCH

Niclosamide: An Established Antihelminthic Drug as a Potential Therapy Against S100A4-Mediated Metastatic Colon Tumors

(2011) D. M. Helfman   JNCI-Journal of the National Cancer Institute

Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer

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FZD7 has a critical role in cell proliferation in triple negative breast cancer

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Molecular Stratification of Triple-Negative Breast Cancers

(2011) C. M. Perou   ONCOLOGIST

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

(2011) Wenyan Lu et al.   PLoS One

Antitumorigenic potential of STAT3 alternative splicing modulation

(2011) F. Zammarchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

(2011) F L Khanim et al.   Blood Cancer Journal

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

Cytoplasmic Localization of  -Catenin is a Marker of Poor Outcome in Breast Cancer Patients

(2010) E. Lopez-Knowles et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

(2010) Xiaomei Ren et al.   ACS Medicinal Chemistry Letters

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

(2009) Minyong Chen et al.   BIOCHEMISTRY

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells

(2009) An-Ming Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

(2009) Yunsong Tong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology