Why Two? On the Role of (A-)Symmetry in Negative Supercoiling of DNA by Gyrase

Gyrase containing a single C-terminal domain catalyzes negative supercoiling of DNA by decreasing the linking number in steps of two

(2018) Jampa Tsedön Stelljes et al.   NUCLEIC ACIDS RESEARCH

Binding and Hydrolysis of a Single ATP Is Sufficient for N-Gate Closure and DNA Supercoiling by Gyrase

(2017) Simon Hartmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase

(2017) Wareed Ahmed et al.   PLoS Genetics

DNA gyrase with a single catalytic tyrosine can catalyze DNA supercoiling by a nicking-closing mechanism

(2016) Airat Gubaev et al.   NUCLEIC ACIDS RESEARCH

The mechanism of negative DNA supercoiling: A cascade of DNA-induced conformational changes prepares gyrase for strand passage

(2014) Airat Gubaev et al.   DNA REPAIR

The Acidic C-terminal Tail of the GyrA Subunit Moderates the DNA Supercoiling Activity ofBacillus subtilisGyrase

(2014) Martin A. Lanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Regulation of Promoter Melting in Naive Lymphocytes

(2013) Fedor Kouzine et al.   CELL

Mapping the Spectrum of Conformational States of the DNA- and C-Gates in Bacillus subtilis Gyrase

(2013) Markus G. Rudolph et al.   JOURNAL OF MOLECULAR BIOLOGY

Transcription-dependent dynamic supercoiling is a short-range genomic force

(2013) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase

(2013) Julie Papillon et al.   NUCLEIC ACIDS RESEARCH

Potassium Ions Are Required for Nucleotide-induced Closure of Gyrase N-gate

(2012) Airat Gubaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs

(2012) Elsa M. Tretter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs

(2012) Elsa M. Tretter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The GyrA-box determines the geometry of DNA bound to gyrase and couples DNA binding to the nucleotide cycle

(2012) Martin A. Lanz et al.   NUCLEIC ACIDS RESEARCH

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

(2011) Frédéric Collin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage

(2011) Jinjun Wu et al.   NUCLEIC ACIDS RESEARCH

Guiding strand passage: DNA-induced movement of the gyrase C-terminal domains defines an early step in the supercoiling cycle

(2011) Martin A. Lanz et al.   NUCLEIC ACIDS RESEARCH

DNA-induced narrowing of the gyrase N-gate coordinates T-segment capture and strand passage

(2011) A. Gubaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In front of and behind the replication fork: bacterial type IIA topoisomerases

(2010) Claudia Sissi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The DNA-gate of Bacillus subtilis gyrase is predominantly in the closed conformation during the DNA supercoiling reaction

(2009) A. Gubaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS