Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy

(2017) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

(2017) Louise Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review

(2017) Sherry G. Mansour et al.   BMC Nephrology

Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs

(2016) Alessandra Castaldi et al.   CELLULAR SIGNALLING

Novel anti-inflammatory drugs for the treatment of diabetic kidney disease

(2016) Hiddo J. L. Heerspink et al.   DIABETOLOGIA

Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium

(2016) Panfeng Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN- γ

(2016) Amandeep Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c

(2016)   MOLECULES AND CELLS

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

(2016) Sina M. Coldewey et al.   Scientific Reports

Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human

(2016) Masaya Sato et al.   Scientific Reports

Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts

(2015) Stephanie Schwalm et al.   BIOLOGICAL CHEMISTRY

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

(2015) Michael S. Donoviel et al.   FASEB JOURNAL

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway

(2014) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury

(2014) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

(2014) Jing Chen et al.   PLoS Genetics

Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway to Treat Chronic Inflammatory Kidney Diseases

(2013) Stephanie Schwalm et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Role of the EGF receptor in PPARγ-mediated sodium and water transport in human proximal tubule cells

(2013) S. Saad et al.   DIABETOLOGIA

Inhibition of KCa3.1 suppresses TGF-β1 induced MCP-1 expression in human proximal tubular cells through Smad3, p38 and ERK1/2 signaling pathways

(2013) Chunling Huang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages

(2013) Yuquan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

(2012) Stephanie Schwalm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis

(2012) Nigel J. Pyne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

(2012) Shigetomo Fukuhara et al.   JOURNAL OF CLINICAL INVESTIGATION

Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia

(2012) Arkady Rutkovskiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells

(2011) Phillip Callihan et al.   NEUROPHARMACOLOGY

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

(2010) Andrea Huwiler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

The Expression of Aquaporin-1 in the Medulla of the Kidney Is Dependent on the Transcription Factor Associated with Hypertonicity, TonEBP

(2010) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice

(2010) SO-YOUNG LEE et al.   NEPHROLOGY

Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells

(2009) Andreas Billich et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes

(2009) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

(2009) Shuyu Ren et al.   KIDNEY INTERNATIONAL

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

SPHINGANINE-1-PHOSPHATE ATTENUATES BOTH HEPATIC AND RENAL INJURY INDUCED BY HEPATIC ISCHEMIA AND REPERFUSION IN MICE

(2009) Sang Won Park et al.   SHOCK

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE