Advances in the Genetics of Hypertension: The Effect of Rare Variants

Is There a Role for Genomics in the Management of Hypertension?

(2017) Jacopo Burrello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rare coding variants associated with blood pressure variation in 15 914 individuals of African ancestry

(2017) Priyanka Nandakumar et al.   JOURNAL OF HYPERTENSION

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

Genetic mechanisms of human hypertension and their implications for blood pressure physiology

(2017) Eric Seidel et al.   PHYSIOLOGICAL GENOMICS

A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

(2017) Carmine Vecchione et al.   Scientific Reports

A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension

(2017) Koichiro Higasa et al.   BMC Pulmonary Medicine

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure

(2017) Karen Y. He et al.   PLoS Genetics

Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin–Angiotensin–Aldosterone System and Blood PressureCLINICAL PERSPECTIVE

(2017) Katrina J. Scurrah et al.   Circulation-Cardiovascular Genetics

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCLINICAL PERSPECTIVE

(2017) Aldi T. Kraja et al.   Circulation-Cardiovascular Genetics

Genetic Predisposition to High Blood Pressure and Lifestyle Factors

(2017) Raha Pazoki et al.   CIRCULATION

Boosting the Power of the Sequence Kernel Association Test by Properly Estimating Its Null Distribution

(2016) Kai Wang   AMERICAN JOURNAL OF HUMAN GENETICS

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population

(2016) Yun Kyoung Kim et al.   Cardiovascular Diabetology

A W-test collapsing method for rare-variant association testing in exome sequencing data

(2016) Rui Sun et al.   GENETIC EPIDEMIOLOGY

A stop-codon of the phosphodiesterase 11A gene is associated with elevated blood pressure and measures of obesity

(2016) Therese Ohlsson et al.   JOURNAL OF HYPERTENSION

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and AngiogenesisNovelty and Significance

(2015) Francesco Villa et al.   CIRCULATION RESEARCH

Genetic and Molecular Aspects of Hypertension

(2015) S. Padmanabhan et al.   CIRCULATION RESEARCH

Rare Exome Sequence Variants inCLCN6Reduce Blood Pressure Levels and Hypertension RiskCLINICAL PERSPECTIVE

(2015) Bing Yu et al.   Circulation-Cardiovascular Genetics

The Role of Rare Variants in Systolic Blood Pressure: Analysis of ExomeChip Data in HyperGEN African Americans

(2015) Yun Ju Sung et al.   HUMAN HEREDITY

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

(2015) Bernard C. Rossier et al.   PHYSIOLOGICAL REVIEWS

Rare Exome Sequence Variants inCLCN6Reduce Blood Pressure Levels and Hypertension RiskCLINICAL PERSPECTIVE

(2015) Bing Yu et al.   Circulation-Cardiovascular Genetics

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

(2015) Ngan T. Tran et al.   Frontiers in Genetics

Strategies to Design and Analyze Targeted Sequencing Data: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study

(2014) H. Lin et al.   Circulation-Cardiovascular Genetics

Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

(2014) Esin Karaman et al.   CYTOTECHNOLOGY

A Unified Sparse Representation for Sequence Variant Identification for Complex Traits

(2014) Shaolong Cao et al.   GENETIC EPIDEMIOLOGY

CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs

(2014) Margus Putku et al.   HUMAN GENETICS

Sequence Analysis of Six Blood Pressure Candidate Regions in 4,178 Individuals: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study

(2014) Alanna C. Morrison et al.   PLoS One

Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat

(2013) Santosh S. Atanur et al.   CELL

Advances in Blood Pressure Genomics

(2013) Patricia B. Munroe et al.   CIRCULATION RESEARCH

Epithelial sodium channel (ENaC) and the control of blood pressure

(2013) Bernard C Rossier   CURRENT OPINION IN PHARMACOLOGY

Target Sequencing, Cell Experiments, and a Population Study Establish Endothelial Nitric Oxide Synthase ( eNOS ) Gene as Hypertension Susceptibility Gene

(2013) Erika Salvi et al.   HYPERTENSION

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Rare Variant Analysis for Family-Based Design

(2013) Gourab De et al.   PLoS One

Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium

(2013) Megan L. Grove et al.   PLoS One

Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies

(2012) Seunggeun Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Optimal tests for rare variant effects in sequencing association studies

(2012) S. Lee et al.   BIOSTATISTICS

Fibrillin-1 genotype and risk of prevalent hypertension: A study in two independent populations

(2012) Jørgen Jeppesen et al.   BLOOD PRESSURE

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

(2012) Sarah R. Langley et al.   CARDIOVASCULAR RESEARCH

Detecting Association of Rare and Common Variants by Testing an Optimally Weighted Combination of Variants

(2012) Qiuying Sha et al.   GENETIC EPIDEMIOLOGY

Sequence Kernel Association Test for Quantitative Traits in Family Samples

(2012) Han Chen et al.   GENETIC EPIDEMIOLOGY

Regulation of Epithelial Sodium Channel Trafficking by Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

(2012) Vikas Sharotri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

A powerful test for multiple rare variants association studies that incorporates sequencing qualities

(2012) Z. John Daye et al.   NUCLEIC ACIDS RESEARCH

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese

(2011) Shu-Ping Gao et al.   CYTOKINE

Comparison of statistical tests for disease association with rare variants

(2011) Saonli Basu et al.   GENETIC EPIDEMIOLOGY

Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

(2011) Thomas J. Hoffmann et al.   GENOMICS

Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase

(2011) Erika Salvi et al.   HYPERTENSION

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

Testing for an Unusual Distribution of Rare Variants

(2011) Benjamin M. Neale et al.   PLoS Genetics

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

(2010) Casey E. Romanoski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Genetics of Blood Pressure and Hypertension: The Role of Rare Variation

(2010) Peter A. Doris   Cardiovascular Therapeutics

CAPL: a novel association test using case-control and family data and accounting for population stratification

(2010) Ren-Hua Chung et al.   GENETIC EPIDEMIOLOGY

Statistical analysis strategies for association studies involving rare variants

(2010) Vikas Bansal et al.   NATURE REVIEWS GENETICS

A guide and guard: The many faces of T-cadherin

(2009) Maria Philippova et al.   CELLULAR SIGNALLING

Asymptotic tests of association with multiple SNPs in linkage disequilibrium

(2009) Wei Pan   GENETIC EPIDEMIOLOGY

An evaluation of statistical approaches to rare variant analysis in genetic association studies

(2009) Andrew P. Morris et al.   GENETIC EPIDEMIOLOGY

Genetic Analysis of Blood Pressure in 8 Mouse Intercross Populations

(2009) Minjie Feng et al.   HYPERTENSION

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

(2009) Murim Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic

(2009) Bo Eskerod Madsen et al.   PLoS Genetics

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

(2008) Bingshan Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine

(2008) P. Elliott et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

(2008) Michal Pravenec et al.   NATURE GENETICS

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

(2008) Weizhen Ji et al.   NATURE GENETICS