Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2

Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail

(2015) Y. Yang et al.   BIOCHEMICAL JOURNAL

Polycystin-2 (TRPP2) Regulation by Ca2+ Is Effected and Diversified by Actin-Binding Proteins

(2015) María del Rocío Cantero et al.   BIOPHYSICAL JOURNAL

The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function

(2015) María del Rocío Cantero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of the Polycystin-2 C-terminal Tail and Effects on Its Ca2+-binding Properties

(2015) Yifei Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site

(2015) X. Su et al.   JOURNAL OF CELL SCIENCE

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

(2015) Vladimir G. Gainullin et al.   JOURNAL OF CLINICAL INVESTIGATION

A polycystin-centric view of cyst formation and disease: the polycystins revisited

(2015) Albert C.M. Ong et al.   KIDNEY INTERNATIONAL

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Vasopressin and disruption of calcium signalling in polycystic kidney disease

(2015) Fouad T. Chebib et al.   Nature Reviews Nephrology

The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function

(2014) Ivana Y. Kuo et al.   FASEB JOURNAL

Structural Basis for Calcium and Magnesium Regulation of a Large Conductance Calcium-activated Potassium Channel with β1 Subunits

(2014) Hao-Wen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyst formation following disruption of intracellular calcium signaling

(2014) Ivana Y. Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-resolution structure of the EF-hand domain of human polycystin-2

(2014) Mark D. Allen et al.   PROTEIN SCIENCE

Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: A QCM study based on solid supported membranes

(2013) Daniela Morick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Explicit Formulation Approach for the Analysis of Calcium Binding to EF-Hand Proteins Using Isothermal Titration Calorimetry

(2013) Camille Keeler et al.   BIOPHYSICAL JOURNAL

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation

(2013) Andrew J. Streets et al.   HUMAN MOLECULAR GENETICS

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are Necessary for Channel Gating

(2012) Andjelka S. Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin

(2012) Qian Wang et al.   PLoS One

Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

(2012) S. Yoshiba et al.   SCIENCE

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach

(2011) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain

(2011) F. M. Ferreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the interaction of the C-terminal regions of polycystin-2 and polycystin-1 attached to a lipid bilayer by means of QCM

(2010) Daniela Behn et al.   BIOPHYSICAL CHEMISTRY

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes

(2010) Aurélie Giamarchi et al.   EMBO JOURNAL

Polycystin-2 Activation by Inositol 1,4,5-Trisphosphate-induced Ca2+Release Requires Its Direct Association with the Inositol 1,4,5-Trisphosphate Receptor in a Signaling Microdomain

(2010) Eva Sammels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase D–mediated Phosphorylation of Polycystin-2 (TRPP2) Is Essential for Its Effects on Cell Growth and Calcium Channel Activity

(2010) Andrew J. Streets et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

(2010) E. T. Petri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

(2009) Yong Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Domain Mapping of the Polycystin-2 C-terminal Tail Usingde NovoMolecular Modeling and Biophysical Analysis

(2008) Andjelka Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2

(2008) Shuang Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Periodic Table of Coiled-Coil Protein Structures

(2008) Efrosini Moutevelis et al.   JOURNAL OF MOLECULAR BIOLOGY