Regulation of Akt/FoxO3a/Skp2 Axis Is Critically Involved in Berberine-Induced Cell Cycle Arrest in Hepatocellular Carcinoma Cells

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

(2017) Wenguang Chang   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth

(2017) Dandan Li et al.   LABORATORY INVESTIGATION

Overexpression of CCAAT Enhancer-Binding Protein α Inhibits the Growth of K562 Cells via the Foxo3a-Bim Pathway

(2016) Guili Zhang et al.   ACTA HAEMATOLOGICA

Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system

(2016) Kun Zou et al.   ACTA PHARMACOLOGICA SINICA

Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma

(2016) Soon Young Park et al.   Oncotarget

Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma

(2015) Chi Man Tsang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine

(2015) Yin-Xu Zhang et al.   CANCER BIOLOGY & THERAPY

Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner

(2015) V. V. Prabhu et al.   CANCER RESEARCH

Current knowledge and pharmacological profile of berberine: An update

(2015) Anil Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

(2015) Ao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

E3 ubiquitin ligase Skp2 as an attractive target in cancer therapy

(2015) Zhonglin Hao   Frontiers in Bioscience-Landmark

Akt Signaling Is Associated with the Berberine-Induced Apoptosis of Human Gastric Cancer Cells

(2015) Tingting Yi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis

(2015) M Sarkar et al.   ONCOGENE

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

(2015) Juan M. Caraballo et al.   Oncotarget

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway

(2014) Tao Jia et al.   Cancer Cell International

Downregulation of FOXO3a Promotes Tumor Metastasis and Is Associated with Metastasis-Free Survival of Patients with Clear Cell Renal Cell Carcinoma

(2014) D. Ni et al.   CLINICAL CANCER RESEARCH

FoxO proteins’ nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells

(2014) Shatrunajay Shukla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prognostic Significance of Capn4 Overexpression in Intrahepatic Cholangiocarcinoma

(2013) Chi Zhang et al.   PLoS One

Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2

(2013) K H Koo et al.   Cell Death & Disease

Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma

(2012) Mary Maluccio et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex

(2012) J Wu et al.   ONCOGENE

Translational medicine in hepatocellular carcinoma

(2012) Qiang Gao et al.   Frontiers of Medicine

Bimodal regulation of FoxO3 by AKT and 14-3-3

(2011) Melissa Dobson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147

(2011) Qian Hou et al.   CANCER SCIENCE

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21

(2011) Yuehua Huang et al.   GASTROENTEROLOGY

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of the SKP2–p27KIP1 pathway in suppression of cancer cell proliferation by RECK

(2011) Y Yoshida et al.   ONCOGENE

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice

(2009) Guan-Yu Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

(2009) Jung-Mu Hur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1

(2009) Jinlong Shi et al.   JOURNAL OF NEURO-ONCOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Final checkup of neoplastic DNA replication: Evidence for failure in decision-making at the mitotic cell cycle checkpoint G1/S

(2008) Gregor Prindull   EXPERIMENTAL HEMATOLOGY

Functional interaction between FOXO3a and ATM regulates DNA damage response

(2008) Wen-Bin Tsai et al.   NATURE CELL BIOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE