Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2

Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells

(2012) Hanhui Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress

(2012) K Ketola et al.   BRITISH JOURNAL OF CANCER

Rapamycin Resistance Is Linked to Defective Regulation of Skp2

(2012) H. Totary-Jain et al.   CANCER RESEARCH

Effects of Salinomycin on Cancer Stem Cell in Human Lung Adenocarcinoma A549 Cells

(2012) Yi Wang   Medicinal Chemistry

Salinomycin Selectively Targets ‘CD133+’ Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines

(2011) Tao-Tao Dong et al.   ANNALS OF SURGICAL ONCOLOGY

Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization

(2011) Kwang-Youn Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer

(2011) Qiao Ming Zhi et al.   BIOMEDICINE & PHARMACOTHERAPY

Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

(2011) Qing-Lian Tang et al.   CANCER LETTERS

Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest

(2011) Won Ki Kim et al.   INVESTIGATIONAL NEW DRUGS

von Hippel–Lindau protein promotes Skp2 destabilization on DNA damage

(2011) J-S Roe et al.   ONCOGENE

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SKP2 Promotes the Radiation Resistance of Esophageal Squamous Cell Carcinoma

(2011) Xiao-Chun Wang et al.   RADIATION RESEARCH

Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China

(2011) Hui-Min Xu et al.   Chinese Journal of Cancer

Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells

(2010) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor

(2010) Roberta Riccioni et al.   BLOOD CELLS MOLECULES AND DISEASES

Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein

(2010) Ju-Hwa Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis

(2010) Rinath Jeselsohn et al.   CANCER CELL

p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies

(2010) S. A. Wander et al.   CLINICAL CANCER RESEARCH

Regulation of Skp2 Levels by the Pim-1 Protein Kinase

(2010) Bo Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells

(2009) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

Deathproof: New Insights on the Role of Skp2 in Tumorigenesis

(2008) Steven I. Reed   CANCER CELL

Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APCCdh1 in G1 phase

(2008) Geneviève Rodier et al.   EMBO JOURNAL