Polyamine Metabolism and Oxidative Protein Folding in the ER as ROS-Producing Systems Neglected in Virology

Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

(2018) Jin-Woo Jeong et al.   Biomolecules & Therapeutics

Organelle luminal dependence of (+)strand RNA virus replication reveals a hidden druggable target

(2018) Masaki Nishikiori et al.   Science Advances

Adaptive responses of heart and skeletal muscle to spermine oxidase overexpression: Evaluation of a new transgenic mouse model

(2017) Roberta Ceci et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

(2017) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip

(2017) Alise J. Ponsero et al.   MOLECULAR CELL

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus

(2017) Kiwamu Hyodo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of ERO1L in gastric cancer and its association with patient prognosis

(2017) Bo Zhou et al.   Experimental and Therapeutic Medicine

Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer

(2017) Tsutomu Tanaka et al.   Oncotarget

C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway

(2017) Rachel Hiu Ha Ching et al.   Oncotarget

Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury

(2017) Kamyar Zahedi et al.   PLoS One

Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells

(2017) Norio Takei et al.   Scientific Reports

Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling

(2016) Amita Shukla-Dave et al.   AMERICAN JOURNAL OF PATHOLOGY

Biosynthesis of polyamines and polyamine-containing molecules

(2016) A. J. Michael   BIOCHEMICAL JOURNAL

Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level

(2016) Tsutomu Tanaka et al.   BRITISH JOURNAL OF CANCER

Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses

(2016) Bryan C. Mounce et al.   Cell Host & Microbe

Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells

(2016) Toshimitsu Kajiwara et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2/ARE Pathway

(2016) Yulia V. Kuzmenko et al.   INTERVIROLOGY

Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses

(2016) Bryan C. Mounce et al.   JOURNAL OF VIROLOGY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

(2016) Olga A. Smirnova et al.   Oxidative Medicine and Cellular Longevity

The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβrather than EnterotoxigenicBacteroides fragilisInfection

(2016) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication

(2016) Michelle E. Olsen et al.   mBio

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

(2016) Alexander V. Ivanov et al.   Oncotarget

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Overexpression of Endoplasmic Reticulum Oxidoreductin 1-α (ERO1L) Is Associated with Poor Prognosis of Gastric Cancer

(2016) So-Young Seol et al.   Cancer Research and Treatment

Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells

(2015) Bruno Ramos-Molina et al.   AMINO ACIDS

Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermineN1-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells

(2015) Swati Mandal et al.   BIOCHEMICAL JOURNAL

The mitochondrial voltage-dependent anion channel 1 in tumor cells

(2015) Varda Shoshan-Barmatz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A PDI-catalyzed thiol–disulfide switch regulates the production of hydrogen peroxide by human Ero1

(2015) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel enzyme with spermine oxidase properties in bovine liver mitochondria: Identification and kinetic characterization

(2015) Emanuela Bonaiuto et al.   FREE RADICAL BIOLOGY AND MEDICINE

ERO1-independent production of H2O2within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

(2015) Tasuku Konno et al.   JOURNAL OF CELL BIOLOGY

Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding

(2015) Tsutomu Tanaka et al.   JOURNAL OF IMMUNOLOGY

Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding

(2015) Kazuharu Kukita et al.   JOURNAL OF IMMUNOLOGY

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Oxidative stress influences positive strand RNA virus genome synthesis and capping

(2015) Rebekah C. Gullberg et al.   VIROLOGY

HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells

(2015) Alexander Ivanov et al.   Viruses-Basel

The polyamine spermine induces the unfolded protein response via the MAPK cascade in Arabidopsis

(2015) G. H. M. Sagor et al.   Frontiers in Plant Science

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Does Influenza A Infection Increase Oxidative Damage?

(2014) Mary P.E. Ng et al.   ANTIOXIDANTS & REDOX SIGNALING

Human copper-dependent amine oxidases

(2014) Joel Finney et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Is mitochondrial generation of reactive oxygen species a trigger for autophagy?

(2014) Yongqiang Chen et al.   Autophagy

Inactivation of mammalian Ero1α is catalysed by specific protein disulfide-isomerases

(2014) Colin Shepherd et al.   BIOCHEMICAL JOURNAL

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

(2014) Henning G. Hansen et al.   BIOSCIENCE REPORTS

The Protective Role of Autophagy inHeterocephalus glaberHepatic Stellate Cells Exposed to H2O2or Nutritional Stress

(2014) Shanmin Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

(2014) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

SEPN1, an endoplasmic reticulum-localized selenoprotein linked to skeletal muscle pathology, counteracts hyperoxidation by means of redox-regulating SERCA2 pump activity

(2014) Marianna Marino et al.   HUMAN MOLECULAR GENETICS

Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function

(2014) Yu Mei et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase

(2014) R Chaturvedi et al.   ONCOGENE

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

(2014) David Olagnier et al.   PLoS Pathogens

Infection and Cancer: Global Distribution and Burden of Diseases

(2014) Jin-Kyoung Oh et al.   Annals of Global Health

eIF5A has a function in the cotranslational translocation of proteins into the ER

(2013) Danuza Rossi et al.   AMINO ACIDS

Polyamines and membrane transporters

(2013) Ahmed A. Abdulhussein et al.   AMINO ACIDS

Expression of the Endoplasmic Reticulum Oxidoreductase Ero1α in Gastro-Intestinal Cancer Reveals a Link Between Homocysteine and Oxidative Protein Folding

(2013) Danielle M. Battle et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1α to Promote Oxidative Protein Folding

(2013) Lei Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Forming disulfides in the endoplasmic reticulum

(2013) Ojore B.V. Oka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer

(2013) Goro Kutomi et al.   CANCER SCIENCE

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Polyamines and cancer: implications for chemotherapy and chemoprevention

(2013) Shannon L. Nowotarski et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity

(2013) Caterina Capone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cryptosporidium parvumInduces an Endoplasmic Stress Response in the Intestinal Adenocarcinoma HCT-8 Cell Line

(2013) Mary Morada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Regulation of Ero1α and Peroxiredoxin 4 Localization in the Secretory Pathway

(2013) Taichi Kakihana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

(2013) Kazutaka Araki et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum: reduced and oxidized glutathione revisited

(2013) J. Birk et al.   JOURNAL OF CELL SCIENCE

Exogenous polyamines promote osteogenic differentiation by reciprocally regulating osteogenic and adipogenic gene expression

(2013) Mon-Juan Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

(2013) S. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

(2013) Yoshimi Sato et al.   Scientific Reports

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus

(2012) A. N. Korovina et al.   BIOCHEMISTRY-MOSCOW

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells

(2012) Olga A. Smirnova et al.   BIOCHIMIE

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

(2012) C.-P. Liang et al.   DIABETES

Expression Profiling and Biochemical Analysis Suggest Stress Response as a Potential Mechanism Inhibiting Proliferation of Polyamine-depleted Cells

(2012) Guy Landau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chikungunya virus–induced autophagy delays caspase-dependent cell death

(2012) Pierre-Emmanuel Joubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

(2012) N Minois et al.   Cell Death & Disease

Regulation of polyamine metabolism by translational control

(2011) Oscar Perez-Leal et al.   AMINO ACIDS

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation

(2011) Lei Wang et al.   BIOCHEMICAL JOURNAL

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

(2011) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Functionalin VitroAnalysis of the ERO1 Protein and Protein-disulfide Isomerase Pathway

(2011) Kazutaka Araki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 Cells

(2011) Alexander V. Ivanov et al.   PLoS One

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes

(2010) Mahua Choudhury et al.   ALCOHOL

Redox State of the Endoplasmic Reticulum Is Controlled by Ero1L-alpha and Intraluminal Calcium

(2010) Balázs Enyedi et al.   ANTIOXIDANTS & REDOX SIGNALING

Chemoprevention of B-Cell Lymphomas by Inhibition of the Myc Target Spermidine Synthase

(2010) T. P. Forshell et al.   Cancer Prevention Research

Ero1α requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)

(2010) Susanna Y. Gilady et al.   CELL STRESS & CHAPERONES

Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum

(2010) Timothy J Tavender et al.   EMBO JOURNAL

Disulphide production by Ero1α–PDI relay is rapid and effectively regulated

(2010) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Suppression of Exogenous Gene Expression by Spermidine/SpermineN1-Acetyltransferase 1 (SSAT1) Cotransfection

(2010) Seung Bum Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin IV protects cells from oxidative stress by removing H2O2 produced during disulphide formation

(2010) T. J. Tavender et al.   JOURNAL OF CELL SCIENCE

Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells

(2010) Marco Prunotto et al.   LABORATORY INVESTIGATION

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis

(2010) Wei-Chung Hsieh et al.   MOLECULES AND CELLS

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-α-mediated apoptosis

(2009) Su-Min Kang et al.   CANCER LETTERS

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc

(2009) Sook-Jeong Lee et al.   GLIA

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

Respiratory Syncytial Virus Infection Induces a Reactive Oxygen Species-MSK1-Phospho-Ser-276 RelA Pathway Required for Cytokine Expression

(2009) M. Jamaluddin et al.   JOURNAL OF VIROLOGY

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

(2009) Mainul Hoque et al.   Retrovirology

IL-4 and IL-13 upregulate ornithine decarboxylase expression by PI3K and MAP kinase pathways in vascular smooth muscle cells

(2008) Liu Hua Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acrolein toxicity: Comparison with reactive oxygen species

(2008) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation

(2008) Karl M Baker et al.   EMBO JOURNAL

Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology

(2008) Tracy Murray-Stewart et al.   FEBS Journal

Increased spermine oxidase (SMO) activity as a novel differentiation marker of myogenic C2C12 cells

(2008) Manuela Cervelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression of antizyme inhibitor 2 in male haploid germinal cells suggests a role in spermiogenesis

(2008) Andrés J. López-Contreras et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Binding of spermine and ifenprodil to a purified, soluble regulatory domain of theN-methyl-d-aspartate receptor

(2008) Xia Han et al.   JOURNAL OF NEUROCHEMISTRY

Spermine signaling plays a significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus

(2008) Yoshiko Mitsuya et al.   JOURNAL OF PLANT PHYSIOLOGY

Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana

(2008) Dong-Ping Lu et al.   MOLECULAR GENETICS AND GENOMICS

Characterization of Arginine Decarboxylase in Rat Brain and Liver

(2003) S. Regunathan et al.   JOURNAL OF NEUROCHEMISTRY