A Simple Method to Reduce both Lactic Acid and Ammonium Production in Industrial Animal Cell Culture

Toward an era of utilizing methionine overproducing hosts for recombinant protein production inEscherichia coli

(2015) Karthik Veeravalli et al.   Bioengineered

Strain engineering to prevent norleucine incorporation during recombinant protein production inEscherichia coli

(2014) Karthik Veeravalli et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Cellular requirements and product quality considerations

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Effects of copper on CHO cells: Insights from gene expression analyses

(2014) Inn H. Yuk et al.   BIOTECHNOLOGY PROGRESS

Metabolic flux rewiring in mammalian cell cultures

(2013) Jamey D Young   CURRENT OPINION IN BIOTECHNOLOGY

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

(2012) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

Characterization of the basic charge variants of a human IgG1

(2012) Timothy Kaschak et al.   mAbs

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

(2012) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

(2011) Jee Yon Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

(2011) Jun Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Controlling glycation of recombinant antibody in fed-batch cell cultures

(2011) Inn H. Yuk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems

(2011) John Paul Smelko et al.   BIOTECHNOLOGY PROGRESS

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

Engineering a mammalian super producer

(2011) Stefanie Dietmair et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

(2009) Ningning Ma et al.   BIOTECHNOLOGY PROGRESS

Metabolic flux analysis in mammalian cell culture

(2009) Lake-Ee Quek et al.   METABOLIC ENGINEERING

Substitution of Glutamine by Pyruvate To Reduce Ammonia Formation and Growth Inhibition of Mammalian Cells

(2005) Yvonne Genzel et al.   BIOTECHNOLOGY PROGRESS

Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed

(2005) Wendy B. Chaderjian et al.   BIOTECHNOLOGY PROGRESS

Temperature Reduction in Cultures of hGM-CSF-expressing CHO Cells: Effect on Productivity and Product Quality

(2005) Mariela Bollati-Fogolín et al.   BIOTECHNOLOGY PROGRESS