Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression

Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences

(2014) Hong-Yi Zheng et al.   EXPERIMENTAL GERONTOLOGY

Innate Functions of Immunoglobulin M Lessen Liver Gene Transfer with Helper-Dependent Adenovirus

(2014) Carmen Unzu et al.   PLoS One

Safety and Liver Transduction Efficacy of rAAV5-cohPBGD in Nonhuman Primates: A Potential Therapy for Acute Intermittent Porphyria

(2013) Astrid Pañeda et al.   HUMAN GENE THERAPY

Transgene Expression up to 7 Years in Nonhuman Primates Following Hepatic Transduction with Helper-Dependent Adenoviral Vectors

(2013) Nicola Brunetti-Pierri et al.   HUMAN GENE THERAPY

Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice

(2013) Carmen Unzu et al.   HUMAN MOLECULAR GENETICS

Circulating Antibodies and Macrophages as Modulators of Adenovirus Pharmacology

(2013) R. Khare et al.   JOURNAL OF VIROLOGY

Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement

(2013) Zhili Xu et al.   NATURE MEDICINE

Improved Efficacy and Reduced Toxicity by Ultrasound-Guided Intrahepatic Injections of Helper-Dependent Adenoviral Vector in Gunn Rats

(2013) Nunzia Pastore et al.   Human Gene Therapy Methods

Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

(2012) Carmen Unzu et al.   Journal of Translational Medicine

Balloon Catheter Delivery of Helper-dependent Adenoviral Vector Results in Sustained, Therapeutic hFIX Expression in Rhesus Macaques

(2012) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

(2011) Reeti Khare et al.   CURRENT GENE THERAPY

Adenoviral Vector Immunity: Its Implications and Circumvention Strategies

(2011) Yadvinder S. Ahi et al.   CURRENT GENE THERAPY

Gene Transfer for Inherited Metabolic Disorders of the Liver: Immunological Challenges

(2011) Stephanie C. Gordts et al.   CURRENT PHARMACEUTICAL DESIGN

Self-inactivating helper virus for the production of high-capacity adenoviral vectors

(2011) M Gonzalez-Aparicio et al.   GENE THERAPY

Helper-dependent adenoviral vectors for liver-directed gene therapy

(2011) N. Brunetti-Pierri et al.   HUMAN MOLECULAR GENETICS

Liver transplantation for acute intermittent porphyria is complicated by a high rate of hepatic artery thrombosis

(2011) Joanna K. Dowman et al.   LIVER TRANSPLANTATION

Generation of a Kupffer Cell-evading Adenovirus for Systemic and Liver-directed Gene Transfer

(2011) Reeti Khare et al.   MOLECULAR THERAPY

Readministration of helper-dependent adenoviral vectors to mouse airway mediated via transient immunosuppression

(2010) H Cao et al.   GENE THERAPY

Porphyrias

(2010) Hervé Puy et al.   LANCET

Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates

(2010) Antonio Fontanellas et al.   MOLECULAR THERAPY

Sustained Enzymatic Correction by rAAV-Mediated Liver Gene Therapy Protects Against Induced Motor Neuropathy in Acute Porphyria Mice

(2010) Carmen Unzu et al.   MOLECULAR THERAPY

Progress and prospects: immune responses to viral vectors

(2009) S Nayak et al.   GENE THERAPY

IgM in microbial infections: Taken for granted?

(2009) Rachael Racine et al.   IMMUNOLOGY LETTERS

Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency

(2009) James M. Wilson   MOLECULAR GENETICS AND METABOLISM

AAV8-mediated Gene Therapy Prevents Induced Biochemical Attacks of Acute Intermittent Porphyria and Improves Neuromotor Function

(2009) Makiko Yasuda et al.   MOLECULAR THERAPY

Combined liver and kidney transplantation in acute intermittent porphyria

(2009) Staffan Wahlin et al.   TRANSPLANT INTERNATIONAL

Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors

(2008) N Brunetti-Pierri et al.   GENE THERAPY

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

(2008) Z. Xu et al.   JOURNAL OF VIROLOGY

The Host Response to Adenovirus, Helper-dependent Adenovirus, and Adeno-associated Virus in Mouse Liver

(2008) Anton P McCaffrey et al.   MOLECULAR THERAPY

Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

(2008) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY