Helper-dependent adenoviral vectors for liver-directed gene therapy

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo

(2014) D. M. Appledorn et al.   JOURNAL OF IMMUNOLOGY

Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII

(2011) Chuhong Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of Hyperbilirubinemia in Gunn Rats Using Clinically Relevant Low Doses of Helper-Dependent Adenoviral Vectors

(2010) David Dimmock et al.   HUMAN GENE THERAPY

Chromosomal Integration of Adenoviral Vector DNA In Vivo

(2010) S. L. Stephen et al.   JOURNAL OF VIROLOGY

Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells

(2010) Jan-Michael Prill et al.   MOLECULAR THERAPY

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

(2009) R. C. Carlisle et al.   BLOOD

Progress Towards Liver and Lung-Directed Gene Therapy with Helper- Dependent Adenoviral Vectors

(2009) Nicola Brunetti-Pierri et al.   CURRENT GENE THERAPY

Short-Term Rescue of Neonatal Lethality in a Mouse Model of Propionic Acidemia by Gene Therapy

(2009) Sean E. Hofherr et al.   HUMAN GENE THERAPY

Bioengineered Factor IX Molecules with Increased Catalytic Activity Improve the Therapeutic Index of Gene Therapy Vectors for Hemophilia B

(2009) Nicola Brunetti-Pierri et al.   HUMAN GENE THERAPY

Adenovirus Activates Complement by Distinctly Different Mechanisms In Vitro and In Vivo: Indirect Complement Activation by Virions In Vivo

(2009) J. Tian et al.   JOURNAL OF VIROLOGY

Host Cell Detection of Noncoding Stuffer DNA Contained in Helper-Dependent Adenovirus Vectors Leads to Epigenetic Repression of Transgene Expression

(2009) P. J. Ross et al.   JOURNAL OF VIROLOGY

Redundant and Synergistic Mechanisms Control the Sequestration of Blood-born Adenovirus in the Liver

(2009) Nelson C Di Paolo et al.   MOLECULAR THERAPY

Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector

(2009) Chia-Ling Gau et al.   MOLECULAR THERAPY

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

(2009) Sergey S Seregin et al.   MOLECULAR THERAPY

Induction of Shock After Intravenous Injection of Adenovirus Vectors: A Critical Role for Platelet-activating Factor

(2009) Zhili Xu et al.   MOLECULAR THERAPY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver

(2008) Jeffrey S. Smith et al.   HUMAN GENE THERAPY

Coating of adenovirus type 5 with polymers containing quaternary amines prevents binding to blood components

(2008) Vladimir Subr et al.   JOURNAL OF CONTROLLED RELEASE

Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors

(2008) Nicola Brunetti-Pierri et al.   JOURNAL OF GENE MEDICINE

Clearance of Adenovirus by Kupffer Cells Is Mediated by Scavenger Receptors, Natural Antibodies, and Complement

(2008) Z. Xu et al.   JOURNAL OF VIROLOGY

Gene Therapy for Diabetes: Metabolic Effects of Helper-dependent Adenoviral Exendin 4 Expression in a Diet-induced Obesity Mouse Model

(2008) Susan L Samson et al.   MOLECULAR THERAPY

Efficient, Long-term Hepatic Gene Transfer Using Clinically Relevant HDAd Doses by Balloon Occlusion Catheter Delivery in Nonhuman Primates

(2008) Nicola Brunetti-Pierri et al.   MOLECULAR THERAPY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA