Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach

Ultramicronized Palmitoylethanolamide (um-PEA): A New Possible Adjuvant Treatment in COVID-19 patients

(2021) Annalisa Noce et al.   Pharmaceuticals

Micronized / ultramicronized palmitoylethanolamide (PEA) as natural neuroprotector against COVID-19 inflammation

(2021) Luca Roncati et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The role of Annexin A1 and formyl peptide receptor 2/3 signaling on chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory

(2020) Alessio Filippo Peritore et al.   CNS & Neurological Disorders-Drug Targets

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Ultramicronized Palmitoylethanolamide and Paracetamol, a New Association to Relieve Hyperalgesia and Pain in a Sciatic Nerve Injury Model in Rat

(2020) Alessio Filippo Peritore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High IL‐6/IFN‐γ ratio could be associated with severe disease in COVID‐19 patients

(2020) Francisco Alejandro Lagunas‐Rangel et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway

(2020) Tao Li et al.   MOLECULAR IMMUNOLOGY

ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain

(2020) Ramona D’Amico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effect of Colchicine on LPS-Induced Lung Injury in Rats via Inhibition of P-38, ERK1/2, and JNK Activation

(2020) Qianyu Yue et al.   PHARMACOLOGY

Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis

(2020) Roberta Fusco et al.   Antioxidants

The Role of Cashew (Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease

(2020) Roberta Fusco et al.   Antioxidants

The Protective Effects of Pre- and Post-Administration of Micronized Palmitoylethanolamide Formulation on Postoperative Pain in Rats

(2020) Rosalba Siracusa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sodium chromo-glycate and palmitoylethanolamide: A possible strategy to treat mast cell-induced lung inflammation in COVID-19

(2020) Antonio Gigante et al.   MEDICAL HYPOTHESES

NLRC5 negatively regulates inflammatory responses in LPS-induced acute lung injury through NF-κB and p38 MAPK signal pathways

(2020) Yuanyuan Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Jinzhong Li et al.   VIRUS RESEARCH

Dietary Supplementation with Palmitoyl-Glucosamine Co-Micronized with Curcumin Relieves Osteoarthritis Pain and Benefits Joint Mobility

(2020) Enrico Gugliandolo et al.   Animals

Phytotherapics in COVID19 : Why palmitoylethanolamide?

(2020) Marcella Pesce et al.   PHYTOTHERAPY RESEARCH

Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα

(2020) Yitian Li et al.   BIOCHEMICAL PHARMACOLOGY

N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion

(2019) Daniela Impellizzeri et al.   NEUROBIOLOGY OF DISEASE

The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice

(2019) Daniela Impellizzeri et al.   FASEB JOURNAL

Ginsenoside Rb1 ameliorates Staphylococcus aureus-induced Acute Lung Injury through attenuating NF-κB and MAPK activation

(2019) Aftab Shaukat et al.   MICROBIAL PATHOGENESIS

Therapeutic Efficacy of Palmitoylethanolamide and Its New Formulations in Synergy with Different Antioxidant Molecules Present in Diets

(2019) Alessio Filippo Peritore et al.   Nutrients

Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4–MyD88–NF-κB signaling pathway

(2019) Naigang Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity

(2019) Stefania Petrosino et al.   Journal of Neuroinflammation

Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation of Pain, Oxidative Stress, and Inflammation

(2019) Roberta Fusco et al.   Antioxidants

Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury

(2018) Jae-Won Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Involvement Of TLR4 and PPAR-α Receptors in Host Response and NLRP3 Inflammosome Activation, Against Pulmonary Infection with Pseudomosas Aeruginosa

(2018) Enrico Gugliandolo et al.   SHOCK

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

(2018) Stefania Petrosino et al.   Frontiers in Pharmacology

Topical Application of Adelmidrol + Trans-Traumatic Acid Enhances Skin Wound Healing in a Streptozotocin-Induced Diabetic Mouse Model

(2018) Rosalba Siracusa et al.   Frontiers in Pharmacology

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity

(2017) Cristina Travelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of ARDS Severity and Etiology on Short-Term Outcomes

(2017) Haitham El-Haddad et al.   Respiratory Care

Intratracheal LPS administration attenuates the acute hypoxic ventilatory response: Role of brainstem IL-1β receptors

(2017) A.P. Ribeiro et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse

(2017) Fiorentina Roviezzo et al.   Frontiers in Pharmacology

A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome

(2016) Raiko Blondonnet et al.   DISEASE MARKERS

Acute respiratory distress syndrome

(2016) Rob Mac Sweeney et al.   LANCET

Ultramicronized palmitoylethanolamide (PEA-um ® ) in the treatment of idiopathic pulmonary fibrosis

(2016) Rosanna Di Paola et al.   PHARMACOLOGICAL RESEARCH

Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative Stress Pathway

(2016) Yuan Weifeng et al.   PLoS One

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

Key mechanisms governing resolution of lung inflammation

(2016) C. T. Robb et al.   Seminars in Immunopathology

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

(2016) Jeroen Slaats et al.   PLoS Pathogens

Prognostic role of Oct4, CD44 and c-Myc in radio–chemo-resistant oral cancer patients and their tumourigenic potential in immunodeficient mice

(2015) Sharada Sawant et al.   Clinical Oral Investigations

The Acute Respiratory Distress Syndrome: From Mechanism to Translation

(2015) SeungHye Han et al.   JOURNAL OF IMMUNOLOGY

Alveolar NF-κB signaling regulates endotoxin-induced lung inflammation

(2014) Benjamin Lopez et al.   EXPERIMENTAL LUNG RESEARCH

Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

(2014) Daniela Impellizzeri et al.   Journal of Neuroinflammation

Pelagia noctiluca (Scyphozoa) Crude Venom Injection Elicits Oxidative Stress and Inflammatory Response in Rats

(2014) Giuseppe Bruschetta et al.   Marine Drugs

Palmitoylethanolamide in CNS health and disease

(2014) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples

(2014) Frency Varghese et al.   PLoS One

Palmitoylethanolamide in Homeostatic and Traumatic Central Nervous System Injuries

(2013) Emanuela Esposito et al.   CNS & Neurological Disorders-Drug Targets

A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury

(2013) Irene Paterniti et al.   Journal of Neuroinflammation

Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats

(2012) Pinjie Huang et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus

(2012) Y. Hu et al.   JOURNAL OF VIROLOGY

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

(2011) Caterina Scuderi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biological implications of preformed mast cell mediators

(2010) Anders Lundequist et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization

(2007) Hyung S. Youn et al.   BIOCHEMICAL PHARMACOLOGY