Chimpanzee adenoviral vectors as vaccines – challenges to move the technology into the fast lane

Viral Vector Malaria Vaccines Induce High-Level T Cell and Antibody Responses in West African Children and Infants

(2017) Carly M. Bliss et al.   MOLECULAR THERAPY

Chimpanzee Adenovirus Vector Ebola Vaccine

(2017) Julie E. Ledgerwood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques

(2017) Diane L. Bolton et al.   VACCINE

Exploiting Mucosal Immunity for Antiviral Vaccines

(2016) Akiko Iwasaki   Annual Review of Immunology

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

(2016) Milagritos D Tapia et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study

(2016) Olga De Santis et al.   LANCET INFECTIOUS DISEASES

Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer

(2016) Mitsuhiro Machitani et al.   MOLECULAR CANCER THERAPEUTICS

Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs

(2016) Julio Alonso-Padilla et al.   MOLECULAR THERAPY

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

(2016) Selidji T. Agnandji et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

(2016) Katie Ewer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimpanzee adenovirus vector-based avian influenza vaccine completely protects mice against lethal challenge of H5N1

(2016) Tao Cheng et al.   VACCINE

Viral vectors as vaccine carriers

(2016) Hildegund CJ Ertl   Current Opinion in Virology

Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever

(2016) George M. Warimwe et al.   Scientific Reports

Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling

(2015) Kylie M. Quinn et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

(2015) Ana Maria Henao-Restrepo et al.   LANCET

Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection

(2015) M Jeyanathan et al.   Mucosal Immunology

Chimpanzee adenovirus– and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults

(2015) Christopher A. Green et al.   Science Translational Medicine

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

(2015) Geraldine Taylor et al.   Science Translational Medicine

Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

(2015) Caroline Ogwang et al.   Science Translational Medicine

Improvement of BCG protective efficacy with a novel chimpanzee adenovirus and a modified vaccinia Ankara virus both expressing Ag85A

(2015) E. Stylianou et al.   VACCINE

The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species

(2015) Matthew D.J. Dicks et al.   VACCINE

Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man

(2015) Beatrice Bolinger et al.   Cell Reports

Inflammasome control of viral infection

(2015) Christopher Lupfer et al.   Current Opinion in Virology

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

(2014) Jose Luis Perez-Gracia et al.   CURRENT OPINION IN IMMUNOLOGY

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

(2014) Susanne H. Hodgson et al.   JOURNAL OF INFECTIOUS DISEASES

Construction and Evaluation of Novel Rhesus Monkey Adenovirus Vaccine Vectors

(2014) Peter Abbink et al.   JOURNAL OF VIROLOGY

Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial

(2014) Susanne H Hodgson et al.   MOLECULAR THERAPY

Fusion of HCV Nonstructural Antigen to MHC Class II–associated Invariant Chain Enhances T-cell Responses Induced by Vectored Vaccines in Nonhuman Primates

(2014) Stefania Capone et al.   MOLECULAR THERAPY

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

(2014) Daphne A Stanley et al.   NATURE MEDICINE

Enhanced Vaccine-Induced CD8+ T Cell Responses to Malaria Antigen ME-TRAP by Fusion to MHC Class II Invariant Chain

(2014) Alexandra J. Spencer et al.   PLoS One

Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial

(2014) Emma-Jo Hayton et al.   PLoS One

A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS

(2014) Eoghan de Barra et al.   PLoS One

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

(2014) L. Swadling et al.   Science Translational Medicine

Protection of non-human primates against rabies with an adenovirus recombinant vaccine

(2014) Z.Q. Xiang et al.   VIROLOGY

Carbohydrate-Based Ice Recrystallization Inhibitors Increase Infectivity and Thermostability of Viral Vectors

(2014) Shahrokh M. Ghobadloo et al.   Scientific Reports

The prevalence of neutralising antibodies to chimpanzee adenovirus type 6 and type 7 in healthy adult volunteers, patients with chronic hepatitis B and patients with primary hepatocellular carcinoma in China

(2013) Li Jian et al.   ARCHIVES OF VIROLOGY

Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Seroprevalence of neutralizing antibodies to human adenoviruses type-5 and type-26 and chimpanzee adenovirus type-68 in healthy Chinese adults

(2013) Shujun Zhang et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Genetic Vaccine for Respiratory Syncytial Virus Provides Protection Without Disease Potentiation

(2013) Teresa R Johnson et al.   MOLECULAR THERAPY

Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1

(2013) Nicola Borthwick et al.   MOLECULAR THERAPY

Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus

(2013) Alessandra Vitelli et al.   PLoS One

Comparison of Systemic and Mucosal Immunization with Helper-Dependent Adenoviruses for Vaccination against Mucosal Challenge with SHIV

(2013) Eric A. Weaver et al.   PLoS One

The Viruses of Wild Pigeon Droppings

(2013) Tung Gia Phan et al.   PLoS One

Dry-Coated Live Viral Vector Vaccines Delivered by Nanopatch Microprojections Retain Long-Term Thermostability and Induce Transgene-Specific T Cell Responses in Mice

(2013) Frances E. Pearson et al.   PLoS One

Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley Fever vaccine in mice

(2013) George M Warimwe et al.   Virology Journal

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

(2013) Katie J. Ewer et al.   Nature Communications

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

(2012) Geraldine A. O’Hara et al.   JOURNAL OF INFECTIOUS DISEASES

Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys

(2012) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

(2012) Susanne H Sheehy et al.   MOLECULAR THERAPY

Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

(2012) Susanne H. Sheehy et al.   PLoS One

A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity

(2012) Matthew D. J. Dicks et al.   PLoS One

Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity

(2012) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species

(2012) S. Colloca et al.   Science Translational Medicine

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

(2012) E. Barnes et al.   Science Translational Medicine

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

(2011) Nicole Frahm et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors

(2011) Susanne H Sheehy et al.   MOLECULAR THERAPY

Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation

(2011) W. C. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective anti-Pseudomonas aeruginosa humoral and cellular mucosal immunity by AdC7-mediated expression of the P. aeruginosa protein OprF

(2011) Anja Krause et al.   VACCINE

Creation of a panel of vectors based on ape adenovirus isolates

(2010) Soumitra Roy et al.   JOURNAL OF GENE MEDICINE

Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8+ T Lymphocytes

(2010) D. R. Kaufman et al.   JOURNAL OF VIROLOGY

Adenovirus-Based Vaccines: Comparison of Vectors from Three Species ofAdenoviridae

(2010) H. Chen et al.   JOURNAL OF VIROLOGY

Vaccination with Ad5 Vectors Expands Ad5-Specific CD8+ T Cells without Altering Memory Phenotype or Functionality

(2010) Natalie A. Hutnick et al.   PLoS One

Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses

(2010) Graeme E. Price et al.   PLoS One

Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

(2010) Christoph A. Kahl et al.   VACCINE

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

(2010) Natalie A. Hutnick et al.   VACCINE

Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

(2009) A. Reyes-Sandoval et al.   INFECTION AND IMMUNITY

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

(2009) R. S. Akondy et al.   JOURNAL OF IMMUNOLOGY

Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

(2009) Kara L O'Brien et al.   NATURE MEDICINE

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells

(2009) Natalie A Hutnick et al.   NATURE MEDICINE

Adenovirus receptors: implications for tropism, treatment and targeting

(2009) Niklas Arnberg   REVIEWS IN MEDICAL VIROLOGY

Prevalence of serum neutralizing antibodies against chimpanzee adenovirus 63 and human adenovirus 5 in Kenyan Children, in the context of vaccine vector efficacy

(2009) M. Dudareva et al.   VACCINE

Safety studies on an adenovirus recombinant vaccine for rabies (AdRG1.3-ONRAB®) in target and non-target species

(2009) M. Kimberly Knowles et al.   VACCINE

Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates

(2009) Soumitra Roy et al.   PLoS Pathogens

Single-dose immunogenicity and protective efficacy of simian adenoviral vectors againstPlasmodium berghei

(2008) Arturo Reyes-Sandoval et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Host Immune Responses to Chronic Adenovirus Infections in Human and Nonhuman Primates

(2008) R. Calcedo et al.   JOURNAL OF VIROLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY