Cetacea are natural knockouts for IL20

Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands

(2018) Mark S. Springer et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

A genomics approach reveals insights into the importance of gene losses for mammalian adaptations

(2018) Virag Sharma et al.   Nature Communications

Their loss is our gain: regressive evolution in vertebrates provides genomic models for uncovering human disease loci

(2017) Christopher A Emerling et al.   JOURNAL OF MEDICAL GENETICS

Unusual loss of chymosin in mammalian lineages parallels neo-natal immune transfer strategies

(2017) Mónica Lopes-Marques et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Epidermal cornification is preceded by the expression of a keratinocyte-specific set of pyroptosis-related genes

(2017) Julia Lachner et al.   Scientific Reports

Evolution by gene loss

(2016) Ricard Albalat et al.   NATURE REVIEWS GENETICS

Lessons from non-canonical splicing

(2016) Christopher R. Sibley et al.   NATURE REVIEWS GENETICS

Coding exon-structure aware realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation

(2016) Virag Sharma et al.   NUCLEIC ACIDS RESEARCH

Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis

(2016) Yu-Hsiang Hsu et al.   Scientific Reports

Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins

(2015) Bettina Strasser et al.   EXPERIMENTAL DERMATOLOGY

Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales

(2015) Benjamin A. Braun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RELAX: Detecting Relaxed Selection in a Phylogenetic Framework

(2014) Joel O. Wertheim et al.   MOLECULAR BIOLOGY AND EVOLUTION

A comprehensive survey of non-canonical splice sites in the human transcriptome

(2014) Guillermo E. Parada et al.   NUCLEIC ACIDS RESEARCH

Molecular evolution tracks macroevolutionary transitions in Cetacea

(2014) Michael R. McGowen et al.   TRENDS IN ECOLOGY & EVOLUTION

Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals

(2013) Fabiana Neves et al.   Innate Immunity

Minke whale genome and aquatic adaptation in cetaceans

(2013) Hyung-Soon Yim et al.   NATURE GENETICS

Anti-IL-20 Monoclonal Antibody Suppresses Breast Cancer Progression and Bone Osteolysis in Murine Models

(2012) Y.-H. Hsu et al.   JOURNAL OF IMMUNOLOGY

The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss

(2012) J. J. Morris et al.   mBio

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

(2011) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-24 Transgenic Mice: In Vivo Evidence of Overlapping Functions for IL-20, IL-22, and IL-24 in the Epidermis

(2010) Miao He et al.   JOURNAL OF IMMUNOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM