Article
Biology
Nikolai L. Bjordalsbakke, Jacob T. Sturdy, David R. Hose, Leif R. Hellevik
Summary: This study investigated the feasibility of personalizing a model of systemic hemodynamics by estimating model parameters, including exploring structural identifiability and parameter sensitivity analysis. Results showed that in the noiseless case, all parameters could be calibrated to less than 10-3% error using time series data, while errors using clinical index data could reach over 100%.
MATHEMATICAL BIOSCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Seyedvahid Khodaei, Louis Garber, Mohamed Abdelkhalek, Nima Maftoon, Ali Emadi, Zahra Keshavarz-Motamed
Summary: Despite the benefits of TAVR, many candidates have coronary artery disease. A computational framework was developed to study the impact of TAVR on coronary and cardiac hemodynamics. The results suggest that TAVR may adversely affect coronary hemodynamics and increase left ventricle workload.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Engineering, Biomedical
Zhongyou Li, Wentao Jiang, Junjie Diao, Chong Chen, Kairen Xu, Haidong Fan, Fei Yan
Summary: The study developed a model to simulate the cardiovascular system involving regional skin blood flow and characterized the properties of cardiac cycles. The model effectively demonstrates the normal properties of the cardiovascular system and may be promising in predicting the skin-CS relationship.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Forough Jahandideh, Sareh Panahi, Ronan M. N. Noble, Ferrante S. Gragasin, Rachel G. Khadaroo, Kimberly F. Macala, Stephane L. Bourque
Summary: Sepsis is associated with circulatory dysfunction and organ injury, and the loss of vasoregulatory mechanisms contributes to decreased organ perfusion. This study investigated the development of vascular dysfunction as sepsis progressed to septic shock and found that the mesenteric vasculature exhibited dysregulation before the renal and carotid arteries.
Article
Cardiac & Cardiovascular Systems
Mattia Arduini, Jonathan Pham, Alison L. Marsden, Ian Y. Chen, Daniel B. Ennis, Seraina A. Dual
Summary: Despite limited treatment options for heart failure with preserved ejection fraction (HFpEF), this study proposes a soft robotic extra-aortic counterpulsation strategy and tests its effectiveness using a patient-specific closed-loop hemodynamic model. The results show that the strategy can reduce systolic pressure, decrease stroke work, slightly increase coronary perfusion, but increase left atrial pressures in HFpEF patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Nikolai L. Bjordalsbakke, Jacob Sturdy, Emma M. L. Ingestrom, Leif R. Hellevik
Summary: This study optimized personalized parameters of the cardiovascular system using physics-based models, and investigated the impact of using different pressure waveforms on the results. The findings showed that the compliance values obtained from the finger arterial pressure waveform were higher than those from the carotid waveform. The study also demonstrated that it is possible to differentiate individuals and measurement days based on parameter values using the presented optimization method.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Engineering, Mechanical
Seyedvahid Khodaei, Reza Sadeghi, Philipp Blanke, Jonathon Leipsic, Ali Emadi, Zahra Keshavarz-Motamed
Summary: Aortic stenosis is a cardiovascular disease that often coexists with other complex diseases, requiring accurate hemodynamics quantification for diagnosis. Current diagnostic methods are lacking, necessitating the development of new non-invasive diagnostic methods.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2021)
Article
Engineering, Mechanical
Reza Sadeghi, Nadav Gasner, Seyedvahid Khodaei, Julio Garcia, Zahra Keshavarz-Motamed
Summary: The optimal course of intervention for patients with coexisting coarctation of the aorta (COA) and mixed valvular disease (MVD) is uncertain. This study developed a computational-mechanics framework to investigate the impact of COA and MVD on aortic fluid dynamics. The results suggest that the presence and severity of MVD should be considered in the evaluation of risks in patients with COA.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jianning Zhang, Jiawen Liang, Xiaoyu Zhang, Chen Su, Jiang He, Yumin Qiu, Zhe Zhou, Zhichao Wang, Bing Dong, Qiang Tu, Shiyue Xu, Wenhao Xia, Jun Tao
Summary: The study highlights the impact of abnormal hemodynamic states on vascular damage beyond elevated blood pressure in hypertension. While there were significant alterations in systemic vascular resistance index and left stroke work index among different blood pressure stages, heterogeneous subsets of hemodynamics and vascular function were found within similar blood pressure ranges. The findings suggest that a systemic hemodynamic index may serve as a feasible tool for cardiovascular function assessment by showing a negative correlation with vascular damage index.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Physiology
Bao Li, Boyan Mao, Yue Feng, Jincheng Liu, Zhou Zhao, Mengyao Duan, Youjun Liu
Summary: The study demonstrated the importance of FFR values in guiding coronary artery bypass surgery, especially when bypassing lesions with high FFR values to avoid potential complications such as graft failure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Thermodynamics
L. Araneo, R. Clavenna, R. Boubaker, V. Dupont
Summary: The study tested a prototype Capillary Jet Loop Heat Pipe and developed a simplified model to investigate key parameters. Results showed strong relation between performance and orientation, with low dependence on thermal load and condensing temperature.
APPLIED THERMAL ENGINEERING
(2021)
Article
Computer Science, Information Systems
Gi-Young Lee, Min-Shin Cho, Rae-Young Kim
Summary: With the development of wide bandgap power semiconductor technology, the reliability of power converters with high efficiency and high power density is greatly affected by parasitic inductance components in the switching loop. The proposed power loop analysis method based on lumped parameter modeling allows for intuitive and easy analysis of power loops with various current paths, and effectively derives the parasitic inductance component for the main points in the power circuit board. The effectiveness of the lumped parameter model is verified through simulation results.
Article
Engineering, Biomedical
Abraham Umo, Ethan O. O. Kung
Summary: This study introduces a PSCOPE method that can couple in-vitro experiments with a physiological modeling network, addressing the limitation of previous methods in dealing with volumetrically dynamic experiments. The proposed method is capable of accurately coupling multi-branch and volumetrically dynamic in-vitro experiments to a lumped parameter network (LPN). A practical application of coupling an in-vitro renal circulation experiment to the LPN is illustrated, demonstrating the real-world performance within the constraints of the physical experiment.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Peripheral Vascular Disease
Wu Chen, Yiqun Han, Yanwen Wang, Xi Chen, Xinghua Qiu, Weiju Li, Yifan Xu, Tong Zhu
Summary: Glucose metabolic disorders may exacerbate vascular dysfunction associated with short-term ambient PM exposure. The effects of PM on vascular function vary according to glucose metabolic status.
Article
Computer Science, Artificial Intelligence
Nikrouz Bahadormanesh, Benjamin Tomka, Mason Kadem, Seyedvahid Khodaei, Zahra Keshavarz-Motamed
Summary: It provides an overview of aortic stenosis (AS) and its impact on patients, as well as the lack of effective tools for evaluating valve dynamics in clinical practice. The researchers developed a non-invasive computational framework using ultrasound technology, which can serve as a diagnostic tool to assess valve dynamics in patients with AS. The framework was validated using clinical data and demonstrated its accuracy and reliability in analyzing and interpreting clinical data.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Matthias Van Impe, Lisa Caboor, Violette Deleeuw, Margie Olbinado, Julie De Backer, Patrick Sips, Patrick Segers
Summary: This study successfully provides a biomechanical reference for the circulation in adult zebrafish by establishing 3D models of the cardiovascular system. By providing reference values for biomechanical stimuli in wild-type animals and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study investigates whether pulse wave velocity (PWV) can guide in determining appropriate parameter values for the Gasser-Ogden-Holzapfel (GOH) constitutive model. The results show that PWV80 and PWV110 are complementary measures that can reduce the parameter space in arterial models, particularly for media- and collagen-related parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Biology
Luis Almeida, Chloe Audebert, Emma Leschiera, Tommaso Lorenzi
Summary: We propose an individual-based model to study the coevolutionary dynamics between CTLs and tumor cells, where each cell is considered as an individual agent and their phenotypic states are modeled using discrete variables. We derive the continuous limit of this model and analyze the steady-state solutions, as well as the linear stability of these solutions, to understand the conditions that lead to different outcomes of immune competition and the emergence of phenotypic coevolution. Our computational results agree well with analytical and numerical results, providing insights into the impact of different parameters on the coevolutionary dynamics between tumor cells and CTLs. These findings support the idea of targeting TCR-tumor antigen binding affinity for immunotherapy and offer a theoretical basis for engineering TCRs to enhance their affinity for cancer targets.
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
(2023)
Review
Endocrinology & Metabolism
Wim Laleman, Michael Praktiknjo, Mette Munk Lauridsen, Lawrence Bonne, Emma Vanderschueren, Chris Verslype, Aleksander Krag, Jonel Trebicka, Geert Maleux
Summary: Spontaneous portosystemic shunts are often overlooked as a cause of hepatic encephalopathy associated with cirrhosis. They are considered as radiological biomarkers of clinically significant portal hypertension and have a clinical impact on complications related to portal hypertension. Interventional radiology embolization is a direct method to target these shunts.
METABOLIC BRAIN DISEASE
(2023)
Article
Gastroenterology & Hepatology
Michiel Bronswijk, Giuseppe Vanella, Roy L. J. van Wanrooij, Jayanta Samanta, Jonas Lauwereys, Enrique Perez-Cuadrado-Robles, Giuseppe Dell'Anna, Jahnvi Dhar, Vikas Gupta, Hannah van Malenstein, Wim Laleman, Joris Jaekers, Halit Topal, Baki Topal, Stefano Crippa, Massimo Falconi, Marc G. Besselink, Nouredin Messaoudi, Paolo Giorgio Arcidiacono, Rastislav Kunda, Schalk Van der Merwe
Summary: Same-session double EUS-guided bypass achieves similar technical and clinical success and is associated with fewer overall and severe adverse events compared to surgical gastroenterostomy and hepaticojejunostomy. Median time to oral intake and hospital stay are significantly shortened in the EUS group. Despite a patient population with more comorbidities, EUS-guided bypass shows promise as a less invasive alternative to surgical double bypass.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Emmanuel Weiss, Carlos de la Pena-Ramirez, Ferran Aguilar, Juan-Jose Lozano, Cristina Sanchez-Garrido, Patricia Sierra, Pedro Izquierdo-Bueno Martin, Juan Manuel Diaz, Francois Fenaille, Florence A. Castelli, Thierry Gustot, Wim Laleman, Agustin Albillos, Carlo Alessandria, Marco Domenicali, Paolo Caraceni, Salvatore Piano, Faouzi Saliba, Stefan Zeuzem, Alexander L. Gerbes, Julia A. Wendon, Christian Jansen, Wenyi Gu, Maria Papp, Raj Mookerjee, Carmine Gabriele Gambino, Cesar Jimenez, Ilaria Giovo, Giacomo Zaccherini, Manuela Merli, Antonella Putignano, Frank Erhard Uschner, Thomas Berg, Tony Bruns, Christian Trautwein, Alexander Zipprich, Rafael Banares, Jose Presa, Joan Genesca, Victor Vargas, Javier Fernandez, Mauro Bernardi, Paolo Angeli, Rajiv Jalan, Joan Claria, Christophe Junot, Richard Moreau, Jonel Trebicka, Vicente Arroyo
Summary: This study aimed to identify metabolites associated with short-term death in patients with acutely decompensated cirrhosis and design metabolomic prognostic models. Three prognostic metabolites strongly associated with death were selected and two models were built, which were found to be more accurate in predicting death within 7, 14, and 28 days compared to traditional scoring systems.
Article
Gastroenterology & Hepatology
Ares Villagrasa, Virginia Hernandez-Gea, Ramon Bataller, Alvaro Giraldez, Bogdan Procopet, Lucio Amitrano, Candid Villanueva, Dominique Thabut, Luis Ibanez-Samaniego, Agustin Albillos, Christophe Bureau, Jonel Trebicka, Elba Llop, Wim Laleman, J. M. Palazon, Jose Castellote, Susana L. Rodrigues, Lise N. Gluud, Carlos Ferreira, Nuria Canete, Manuel Rodriguez, Arnulf L. Ferlitsch, Jose Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'Era, Marco G. Senzolo, Juan Abraldes, Alexander Zipprich, Meritxell Casas, Helena Masnou, Massimo Primignani, Aleksander Krag, Gilberto Silva-Junior, Manuel Romero-Gomez, Marcel A. Tantau, Maria Guardascione, Edilmar Alvarado, Marika Rudler, Rafael Banares, Javier A. Martinez, Marie Robic, Christian L. Jansen, Jose Calleja, Frederik Nevens, Jaime Bosch, Meritxell C. Ventura-Cots, Juan Garcia-Pagan, Joan Genesca
Summary: This study aimed to assess the prevalence of alcohol-related hepatitis (AH) in patients with variceal bleeding and compare the clinical outcomes of AH patients with other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. The results showed that AH patients had more complications and abstinent ALD patients had higher survival rates compared to other groups.
LIVER INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Emma Vanderschueren, Jonel Trebicka, Wim Laleman
Summary: Endoscopy is an indispensable tool in diagnosing and managing liver disease and its complications. It has become an alternative route for interventions and is increasingly being used as a first-line choice. Endoscopic ultrasound is valuable for evaluating liver parenchyma, lesions, and surrounding tissues, as well as guiding portal pressure measurement and managing complications of portal hypertension. Hepatologists should be aware of the full spectrum of diagnostic and therapeutic tools available in this field. Future directions for endoscopy in hepatology are also discussed in this comprehensive review.
SEMINARS IN LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Wenyi Gu, Markus Kimmann, Wim Laleman, Michael Praktiknjo, Jonel Trebicka
Summary: Variceal bleeding is a serious complication of portal hypertension in cirrhosis patients. When combined with acute-on-chronic liver failure (ACLF), variceal bleeding poses a higher risk of treatment failure and short-term mortality. Treating the underlying causes and reducing portal pressure can improve outcomes in patients with acute decompensation or ACLF. Transjugular intrahepatic portosystemic shunts (TIPSs), especially in preemptive cases, have been found to effectively control bleeding, prevent rebleeding, and decrease short-term mortality. Therefore, TIPS placement should be considered as a treatment option for ACLF patients with variceal bleeding.
SEMINARS IN LIVER DISEASE
(2023)
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wenyi Gu, Yasmin Zeleke, Hannah Hortlik, Louisa Schaaf, Frank E. Uschner, Martin Schulz, Michael Tischendorf, Kai-Henrik Peiffer, Maximilian Joseph Brol, Markus Kimmann, Thomas Vogl, Michael Koehler, Carsten Meyer, Alexander Gerbes, Martin Roessle, Wim Laleman, Alexander Zipprich, Christian Steib, Michael Praktiknjo, Jonel Trebicka
Summary: This nationwide study in Germany demonstrates the increasing use of TIPS placement and its positive impact on patients with complications of cirrhosis, particularly in those with ascites and hepatorenal syndrome. However, higher grades of hepatic encephalopathy, infection, and circulatory diseases appear to be associated with increased risk of in-hospital mortality in patients with TIPS insertion.
HEPATOLOGY COMMUNICATIONS
(2023)