The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten

(2017) Matthew J. Stopford et al.   HUMAN MOLECULAR GENETICS

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

(2017) J Chu et al.   MOLECULAR PSYCHIATRY

The most prevalent genetic cause of ALS-FTD, C9orf72 synergizes the toxicity of ATXN2 intermediate polyglutamine repeats through the autophagy pathway

(2016) Sorana Ciura et al.   Autophagy

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis

(2016) Raffaele Ferrari et al.   Molecular Neurodegeneration

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

(2016) Huili Zhu et al.   Scientific Reports

Rab8, POSH, and TAK1 regulate synaptic growth in aDrosophilamodel of frontotemporal dementia

(2015) Ryan J.H. West et al.   JOURNAL OF CELL BIOLOGY

Regulation of Postsynaptic Function by the Dementia-Related ESCRT-III Subunit CHMP2B

(2015) R. Chassefeyre et al.   JOURNAL OF NEUROSCIENCE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins

(2015) Sarin Chimnaronk et al.   BMC STRUCTURAL BIOLOGY

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

TheDrosophilaeffector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB

(2014) Lindsay DeVorkin et al.   JOURNAL OF CELL BIOLOGY

Frontotemporal dementia and its subtypes: a genome-wide association study

(2014) Raffaele Ferrari et al.   LANCET NEUROLOGY

Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia

(2014) Eduardo Gascon et al.   NATURE MEDICINE

Neuroprotection Signaling of Nuclear Akt in Neuronal Cells

(2014) Jee-Yin Ahn   Experimental Neurobiology

SH3RF2 functions as an oncogene by mediating PAK4 protein stability

(2013) Tae Woo Kim et al.   CARCINOGENESIS

Syntaxin 13, a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia, Is Required for Autophagosome Maturation

(2013) Yubing Lu et al.   MOLECULAR CELL

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

POSH Localizes Activated Rac1 to Control the Formation of Cytoplasmic Dilation of the Leading Process and Neuronal Migration

(2012) Tao Yang et al.   Cell Reports

Sh3rf2/POSHER Protein Promotes Cell Survival by Ring-mediated Proteasomal Degradation of the c-Jun N-terminal Kinase Scaffold POSH (Plentyof SH3s) Protein

(2011) Michael Wilhelm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila

(2010) Ming Zhang et al.   Journal of Genetics and Genomics

Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures

(2010) Gernot Kleinberger et al.   JOURNAL OF NEUROCHEMISTRY

POSH is an Intracellular Signal Transducer for the Axon Outgrowth Inhibitor Nogo66

(2010) H. M. Dickson et al.   JOURNAL OF NEUROSCIENCE

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Regulation of the protein stability of POSH and MLK family

(2010) Chunyan Wang et al.   Protein & Cell

The Akt Pathway Is Involved in Rapid Ischemic Tolerance in Focal Ischemia in Rats

(2010) Xuwen Gao et al.   Translational Stroke Research

POSH misexpression induces caspase-dependent cell death in Drosophila

(2009) Ashley L. Lennox et al.   DEVELOPMENTAL DYNAMICS

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

(2009) Hai Wu et al.   MECHANISMS OF DEVELOPMENT

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

(2009) S. T. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Scaffold Protein POSH Regulates Axon Outgrowth

(2008) Jennifer Taylor et al.   MOLECULAR BIOLOGY OF THE CELL