The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells

(2017) Bogdan Beirowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

(2017) Yaqi Deng et al.   Nature Communications

Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

(2017) Monica Ghidinelli et al.   PLOS BIOLOGY

Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

(2017) Gianluca Figlia et al.   eLife

Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS

(2016) E. Domenech-Estevez et al.   JOURNAL OF NEUROSCIENCE

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

(2016) Lai Man Natalie Wu et al.   NATURE NEUROSCIENCE

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

(2016) Minqing Jiang et al.   Nature Communications

Genotype–phenotype characteristics and baseline natural history of heritable neuropathies caused by mutations in theMPZgene

(2015) Oranee Sanmaneechai et al.   BRAIN

New insights on schwann cell development

(2015) Kelly R. Monk et al.   GLIA

Demyelinating CMT–what’s known, what’s new and what’s in store?

(2015) Kathryn M. Brennan et al.   NEUROSCIENCE LETTERS

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

(2015) Sharon W. Way et al.   Nature Communications

Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

(2014) Nicolas Snaidero et al.   CELL

Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development

(2014) Melanie Janning et al.   Future Oncology

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

(2014) S. E. Wahl et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

(2014) Camilla Norrmén et al.   Cell Reports

Jab1 regulates Schwann cell proliferation and axonal sorting through p27

(2013) Emanuela Porrello et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polo-like kinase 2 regulates selective autophagic  -synuclein clearance and suppresses its toxicity in vivo

(2013) A. Oueslati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

Critical Period of Axoglial Signaling between Neuregulin-1 and Brain-Derived Neurotrophic Factor Required for Early Schwann Cell Survival and Differentiation

(2011) Z. Ma et al.   JOURNAL OF NEUROSCIENCE

A functional link between Polo-like kinase 1 and the mammalian Target-Of-Rapamycin pathway?

(2010) Annelies G. Renner et al.   CELL CYCLE

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Molecular mechanisms of inherited demyelinating neuropathies

(2008) Steven S. Scherer et al.   GLIA

The molecular machinery of myelin gene transcription in Schwann cells

(2008) John Svaren et al.   GLIA

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

(2008) Kelly J. Inglis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration

(2008) Junji Yamauchi et al.   JOURNAL OF CELL BIOLOGY

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

The Yeast Tor Signaling Pathway Is Involved in G2/M Transition via Polo-Kinase

(2008) Akio Nakashima et al.   PLoS One