Future perspective for potential Helicobacter pylori eradication therapies

Manuka honey ( Leptospermum scoparium ) inhibits jack bean urease activity due to methylglyoxal and dihydroxyacetone

(2017) Jana Rückriemen et al.   FOOD CHEMISTRY

Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism

(2017) Jiang-Tao Zhou et al.   PLoS One

Plant-Derived Urease Inhibitors as Alternative Chemotherapeutic Agents

(2016) Sherif T. S. Hassan et al.   ARCHIV DER PHARMAZIE

Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori

(2016) Kristof Moonens et al.   Cell Host & Microbe

Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface

(2016) L. Mazzei et al.   DALTON TRANSACTIONS

The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults

(2016) Carlo A. Fallone et al.   GASTROENTEROLOGY

Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus Report

(2016) P Malfertheiner et al.   GUT

Inflammation, immunity, and vaccines forHelicobacter pyloriinfection

(2016) Dominique Velin et al.   HELICOBACTER

Epidemiology ofHelicobacter pyloriinfection

(2016) Mārcis Leja et al.   HELICOBACTER

Piper umbellatum L.: A medicinal plant with gastric-ulcer protective and ulcer healing effects in experimental rodent models

(2016) Iberê Ferreira da Silva Junior et al.   JOURNAL OF ETHNOPHARMACOLOGY

1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors

(2016) Katarzyna Macegoniuk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of Helicobacter pylori infected mice with Bryophyllum pinnatum, a medicinal plant with antioxidant and antimicrobial properties, reduces bacterial load

(2016) Laure Brigitte Kouitcheu Mabeku et al.   PHARMACEUTICAL BIOLOGY

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

(2016) Anahita Javaheri et al.   Nature Microbiology

Review article: the global emergence ofHelicobacter pyloriantibiotic resistance

(2015) I. Thung et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor ofHelicobacter PyloriHtrA

(2015) Anna M. Perna et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyridodiazepine Amines Are Selective Therapeutic Agents for Helicobacter pylori by Suppressing Growth through Inhibition of Glutamate Racemase but Are Predicted To Require Continuous Elevated Levels in Plasma To Achieve Clinical Efficacy

(2015) Boudewijn L. M. de Jonge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

(2015) Ségolène Ruer et al.   Chemical Biology & Drug Design

Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies

(2015) Concepcion Gonzalez-Bello   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Honey and green/black tea consumption may reduce the risk of Helicobacter pylori infection

(2015) Lyudmila Boyanova et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Inflammation, Immunity, and Vaccines forHelicobacter pyloriInfection

(2015) Anna Walduck et al.   HELICOBACTER

The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015)

(2015) György M. Buzás et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dynamic HypA zinc site is essential for acid viability and proper urease maturation in Helicobacter pylori

(2015) Ryan C. Johnson et al.   Metallomics

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

(2015) Nicole Tegtmeyer et al.   MOLECULAR MICROBIOLOGY

Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides

(2015) Joyanta K. Modakh et al.   PLoS One

Effects of Antibiotics on Human Microbiota and Subsequent Disease

(2014) Kristie M. Keeney et al.   Annual Review of Microbiology

Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor

(2014) Robert Ménard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

(2014) James R. Sayer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of bacterial transglycosylase inhibitors as new antibiotics: Moenomycin A treatment for drug-resistant Helicobacter pylori

(2014) Yen-Yu Tseng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of Helicobacter pylori adhesion to human gastric adenocarcinoma epithelial cells by aqueous extracts and pectic polysaccharides from the roots of Cochlospermum tinctorium A. Rich. and Vernonia kotschyana Sch. Bip. ex Walp

(2014) Kari Tvete Inngjerdingen et al.   FITOTERAPIA

Rifabutin-based High-dose Proton-pump Inhibitor and Amoxicillin Triple Regimen as the Rescue treatment forHelicobacter pylori

(2014) Hyun Chul Lim et al.   HELICOBACTER

Global burden of gastric cancer attributable toHelicobacterpylori

(2014) Martyn Plummer et al.   INTERNATIONAL JOURNAL OF CANCER

In silicoapproach towards identification of potential inhibitors ofHelicobacter pyloriDapE

(2014) Rahul Shubhra Mandal et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori

(2014) Xinming Yang et al.   Metallomics

Exploring alternative treatments forHelicobacter pyloriinfection

(2014) Guadalupe Ayala   WORLD JOURNAL OF GASTROENTEROLOGY

Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials

(2014) A. C. Ford et al.   BMJ-British Medical Journal

Anti-Helicobacter pylori xanthones of Garcinia fusca

(2013) Jannarin Nontakham et al.   ARCHIVES OF PHARMACAL RESEARCH

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates

(2013) Jed W. Fahey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

(2013) Gernot Posselt et al.   Cell Communication and Signaling

Resistance mechanism to an uncompetitive inhibitor of a single-substrate, single-product enzyme: a study ofHelicobacter pyloriglutamate racemase

(2013) Thomas A Keating   Future Medicinal Chemistry

Improved Flavodoxin Inhibitors with Potential Therapeutic Effects against Helicobacter pylori Infection

(2013) Juan J. Galano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical application of probiotics in the treatment of Helicobacter pylori infection—A brief review

(2013) Ami Patel et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Anti-Helicobacter pylori and Urease Inhibition Activities of Some Traditional Medicinal Plants

(2013) Muhammad Amin et al.   MOLECULES

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Experimentally Validated Novel Inhibitors of Helicobacter pylori Phosphopantetheine Adenylyltransferase Discovered by Virtual High-Throughput Screening

(2013) Chao-Sheng Cheng et al.   PLoS One

Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy

(2013) L. Gatta et al.   BMJ-British Medical Journal

Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori

(2013) Hilde de Reuse et al.   Frontiers in Cellular and Infection Microbiology

Review article: biofilm formation by Helicobacter pylori as a target for eradication of resistant infection

(2012) G. Cammarota et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty

(2012) Gregory S. Basarab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model

(2012) A. Gomi et al.   JOURNAL OF DAIRY SCIENCE

Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogenHelycobacter pyloriwith anions

(2012) Alfonso Maresca et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Structures of Helicobacter pylori Shikimate Kinase Reveal a Selective Inhibitor-Induced-Fit Mechanism

(2012) Wen-Chi Cheng et al.   PLoS One

Sulforaphane Enhances Protection and Repair of Gastric Mucosa Against Oxidative stress In Vitro, and Demonstrates Anti-inflammatory Effects on Helicobacter pyloriInfected Gastric Mucosae in Mice and Human Subjects

(2011) Akinori Yanaka   CURRENT PHARMACEUTICAL DESIGN

The –Cys–Cys– motif in Helicobacter pylori's Hpn and HspA proteins is an essential anchoring site for metal ions

(2011) Magdalena Rowinska-Zyrek et al.   DALTON TRANSACTIONS

Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review

(2011) Paulina Kosikowska et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemical constituents of Stereospermum acuminatissimum and their urease and α-chymotrypsin inhibitions

(2011) Kamdem Soup T. Ramsay et al.   FITOTERAPIA

BabA-mediated Adherence Is a Potentiator of theHelicobacter pyloriType IV Secretion System Activity

(2011) Nozomi Ishijima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular modeling-based antioxidant arylidene barbiturates as urease inhibitors

(2011) Khalid Mohammed Khan et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Large-scale virtual screening for the identification of new Helicobacter pylori urease inhibitor scaffolds

(2011) Homa Azizian et al.   JOURNAL OF MOLECULAR MODELING

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

(2011) Martin Löwer et al.   PLoS One

Difluoromethylornithine Is a Novel Inhibitor of Helicobacter pylori Growth, CagA Translocation, and Interleukin-8 Induction

(2011) Daniel P. Barry et al.   PLoS One

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

(2011) C. K. Cusumano et al.   Science Translational Medicine

ACTION OF PROTEOLYTIC ENZYMES ON PURIFIED BOVINE SUBMAXILLARY MUCIN*

(2010) Y. Hashimoto et al.   Annals of the New York Academy of Sciences

Novel ProbioticBifidobacterium bifidumCECT 7366 Strain Active against the Pathogenic BacteriumHelicobacter pylori

(2010) E. Chenoll et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Selected South African Honeys and Their Extracts Possess In Vitro Anti-Helicobacter pylori Activity

(2010) Christy E. Manyi-Loh et al.   ARCHIVES OF MEDICAL RESEARCH

The C terminus of HspA—a potential target for native Ni(ii) and Bi(iii) anti-ulcer drugs

(2010) Magdalena Rowinska-Zyrek et al.   DALTON TRANSACTIONS

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol

(2010) Zhong-Lu You et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expression of the BabA Adhesin during Experimental Infection with Helicobacter pylori

(2010) C. M. Styer et al.   INFECTION AND IMMUNITY

Effect of the mucolytic erdosteine on the success rate of PPI-based first-line triple therapy for Helicobacter pylori eradication: a prospective, double-blind, randomized, placebo-controlled study

(2010) Evren Abut et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents againstHelicobacter pyloriInfection

(2009) Nunilo Cremades et al.   ACS Chemical Biology

Pyrazolopyrimidinediones Are Selective Agents for Helicobacter pylori That Suppress Growth through Inhibition of Glutamate Racemase (MurI)

(2009) B. L. M. de Jonge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Green tea inhibits Helicobacter growth in vivo and in vitro

(2009) Calin Stoicov et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Aqueous extracts and polysaccharides from Liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa

(2009) Nicole Wittschier et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors ofHelicobacter pyloriType II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues‡

(2009) Verónica F. V. Prazeres et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase

(2008) Jai-Shin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: A novel pro-drug approach to increase exposure

(2008) Gregory S. Basarab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): Pyridodiazepine amines

(2008) Bolin Geng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Competitive Inhibitors ofHelicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies

(2008) Cristina Sánchez-Sixto et al.   ChemMedChem

The α and β Classes Carbonic Anhydrases from Helicobacter pylori as Novel Drug Targets

(2008) Hiroaki Takeuchi et al.   CURRENT PHARMACEUTICAL DESIGN

Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system

(2008) A. C. Goodwin et al.   MICROBIOLOGY-SGM

In vitroanti-adhesive activity of green tea extract against pathogen adhesion

(2008) Ji-Hye Lee et al.   PHYTOTHERAPY RESEARCH

Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics

(2008) T.-J. R. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA