Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor ofHelicobacter PyloriHtrA

Multidimensional De Novo Design Reveals 5-HT2BReceptor-Selective Ligands

(2014) Tiago Rodrigues et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multi-Objective Molecular De Novo Design by Adaptive Fragment Prioritization

(2014) Michael Reutlinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   ACS Chemical Biology

Steering Target Selectivity and Potency by Fragment-Based De Novo Drug Design

(2013) Tiago Rodrigues et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis

(2013) Gernot Posselt et al.   Cell Communication and Signaling

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?

(2013) Steffen Backert et al.   Cell Communication and Signaling

A Detective Story in Drug Discovery: Elucidation of a Screening Artifact Reveals Polymeric Carboxylic Acids as Potent Inhibitors of RNA Polymerase

(2013) Weixing Zhu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fast, Non-Competitive and Reversible Inhibition of NMDA-Activated Currents by 2-BFI Confers Neuroprotection

(2013) Zhao Han et al.   PLoS One

De novo design and optimization of Aurora A kinase inhibitors

(2013) Tiago Rodrigues et al.   Chemical Science

Drugs by Numbers: Reaction-Driven De Novo Design of Potent and Selective Anticancer Leads

(2012) Birgit Spänkuch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

(2012) Benjamin Hoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

(2012) Christian Seeger et al.   JOURNAL OF MOLECULAR RECOGNITION

An Allosteric Inhibitor of Protein Arginine Methyltransferase 3

(2012) Alena Siarheyeva et al.   STRUCTURE

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

(2012) Manja Boehm et al.   Gut Pathogens

DOGS: Reaction-Driven de novo Design of Bioactive Compounds

(2012) Markus Hartenfeller et al.   PLoS Computational Biology

The structural basis of mode of activation and functional diversity: A case study with HtrA family of serine proteases

(2011) Nitu Singh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Drug discovery in the next decade: innovation needed ASAP

(2011) Youssef L. Bennani   DRUG DISCOVERY TODAY

Soluble E-cadherin: more than a symptom of disease

(2011) Magdalena et al.   Frontiers in Bioscience-Landmark

From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space

(2011) Alexander Klenner et al.   Molecular Informatics

Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

(2011) Martin Löwer et al.   PLoS One

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Host-Bacterial Interactions in Helicobacter pylori Infection

(2008) Manuel R. Amieva et al.   GASTROENTEROLOGY