Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer

Mitochondrial dynamics: The dynamin superfamily and execution by collusion

(2018) Rajesh Ramachandran   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells

(2017) Guangju Zhao et al.   International Journal of Biological Sciences

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer

(2017) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer

(2017) Joan Ballista-Hernández et al.   MOLECULAR CANCER RESEARCH

Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-κB activation

(2017) Untack Cho et al.   MOLECULAR CARCINOGENESIS

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

(2017) Yu-Lu Cao et al.   NATURE

Mitochondrial elongation-mediated glucose metabolism reprogramming is essential for tumour cell survival during energy stress

(2017) J Li et al.   ONCOGENE

Molecular mechanism of DRP1 assembly studied in vitro by cryo-electron microscopy

(2017) Kaustuv Basu et al.   PLoS One

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion

(2017) Juan Zhang et al.   Cell Death & Disease

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission

(2017) Katharina Rehklau et al.   Cell Death & Disease

Targeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucus nigra agglutinin

(2017) Shreya Roy Chowdhury et al.   Cell Death & Disease

Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest

(2017) Hideaki Tsuyoshi et al.   Oncotarget

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

(2017) Chun Guo et al.   Scientific Reports

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

(2017) Marie-Luce Vignais et al.   Stem Cells International

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff

(2017) Rong Yu et al.   Scientific Reports

Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1

(2017) Harish C. Pal et al.   Scientific Reports

Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer

(2017) Christopher A. Francy et al.   Scientific Reports

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission

(2017) So Hee Ko et al.   Scientific Reports

Mitochondrial dynamics during cell cycling

(2016) Rostyslav Horbay et al.   APOPTOSIS

Novel Insights into the Roles of Rho Kinase in Cancer

(2016) Lei Wei et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

Tumour microenvironment factors shaping the cancer metabolism landscape

(2016) Dimitrios Anastasiou   BRITISH JOURNAL OF CANCER

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells

(2016) C.-T. Cheng et al.   CANCER RESEARCH

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer

(2016) Soochi Kim et al.   CANCER SCIENCE

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose

(2016) Julien Prudent et al.   CURRENT BIOLOGY

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle

(2016) Yu Kitaoka et al.   JOURNAL OF APPLIED PHYSIOLOGY

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Multiple dynamin family members collaborate to drive mitochondrial division

(2016) Jason E. Lee et al.   NATURE

SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer

(2016) Z Zhou et al.   ONCOGENE

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells

(2016) Jianye Cai et al.   Cell Death & Disease

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

(2016) Javier Prieto et al.   Nature Communications

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons

(2016) Haibin Wang et al.   PLoS One

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells

(2016) Pengying Li et al.   Scientific Reports

Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis

(2016) Nan Chen et al.   Scientific Reports

Mitochondrial dynamics regulating chemoresistance in gynecological cancers

(2015) Bao Kong et al.   Annals of the New York Academy of Sciences

Intercellular transfer of mitochondria

(2015) E. Y. Plotnikov et al.   BIOCHEMISTRY-MOSCOW

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

(2015) Isabel Diebold et al.   Cell Metabolism

Mitochondrial division and fusion in metabolism

(2015) Madhuparna Roy et al.   CURRENT OPINION IN CELL BIOLOGY

A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division

(2015) Kohei Arasaki et al.   DEVELOPMENTAL CELL

ABT737 enhances cholangiocarcinoma sensitivity to cisplatin through regulation of mitochondrial dynamics

(2015) Zhongqi Fan et al.   EXPERIMENTAL CELL RESEARCH

Base Excision Repair in the Mitochondria

(2015) Aishwarya Prakash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1

(2015) Raymond Liu et al.   MOLECULAR BIOLOGY OF THE CELL

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model

(2015) HUI HAN et al.   Molecular Medicine Reports

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs

(2015) H Mei et al.   Cell Death & Disease

Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis

(2015) Risa Okada et al.   Scientific Reports

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

(2015) Carmela Guido et al.   Oncotarget

Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death

(2014) Ivan Zaja et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial dysfunction in cancer chemoresistance

(2014) Nicoletta Guaragnella et al.   BIOCHEMICAL PHARMACOLOGY

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Shaping the dynamic mitochondrial network

(2014) Laura L Lackner   BMC BIOLOGY

FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells

(2014) Tsai-Hsien Hung et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells

(2014) XIAO-JIAN HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers

(2014) Bao Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria

(2014) J.-Y. Lee et al.   JOURNAL OF CELL SCIENCE

Mitofusin 1 Is Negatively Regulated by MicroRNA 140 in Cardiomyocyte Apoptosis

(2014) J. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission

(2014) Patrick J. Macdonald et al.   MOLECULAR BIOLOGY OF THE CELL

O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

(2014) Christina M. Ferrer et al.   MOLECULAR CELL

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis

(2014) H. P. Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Mitochondrial dysfunction-related genes in hepatocellular carcinoma

(2013) Shusen Zheng   Frontiers in Bioscience-Landmark

Piceatannol Enhances Cisplatin Sensitivity in Ovarian Cancer via Modulation of p53, X-linked Inhibitor of Apoptosis Protein (XIAP), and Mitochondrial Fission

(2013) Lee Farrand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

The connection between inner membrane topology and mitochondrial function

(2013) Carmen A. Mannella et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2

(2013) Ying Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2

(2013) Ayumu Sugiura et al.   MOLECULAR CELL

AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1

(2013) Jakob D. Wikstrom et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

(2013) A Casazza et al.   ONCOGENE

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

(2013) R Kang et al.   ONCOGENE

An Improved Quantitative Approach for the Assessment of Mitochondrial Fragmentation in Chemoresistant Ovarian Cancer Cells

(2013) Lee Farrand et al.   PLoS One

Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

(2013) S. Din et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation

(2013) Joshua K. Salabei et al.   Redox Biology

Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System

(2013) Bongki Cho et al.   Experimental Neurobiology

The dynamin GTPase OPA1: More than mitochondria?

(2012) Pascale Belenguer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2

(2012) L.-Y. Chung et al.   CLINICAL CANCER RESEARCH

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Modulation of Dynamin-related Protein 1 (DRP1) Function by IncreasedO-linked-β-N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

(2012) Thomas Gawlowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

(2012) Kenta Onoue et al.   JOURNAL OF CELL SCIENCE

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

(2012) Lukas Stiburek et al.   MOLECULAR BIOLOGY OF THE CELL

Upregulation of phosphorylated cofilin 1 correlates with taxol resistance in human ovarian cancer in vitro and in vivo

(2012) MIN LI et al.   ONCOLOGY REPORTS

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

(2012) Céline Douarre et al.   PLoS One

GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress

(2012) Chia-Hua Chou et al.   PLoS One

Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens

(2012) R A Anvekar et al.   Cell Death & Disease

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

(2012) James P White et al.   Skeletal Muscle

IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors

(2011) Heba A Alshaker et al.   Cancer Cell International

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

(2011) Jian Zhao et al.   EMBO JOURNAL

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast

(2011) Johannes Förtsch et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Mitochondrial fission and remodelling contributes to muscle atrophy

(2010) Vanina Romanello et al.   EMBO JOURNAL

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo

(2010) Xin Qi et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosis

(2008) Rosalind C. Gregory-Bass et al.   INTERNATIONAL JOURNAL OF CANCER

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

(2008) Akiko Hori et al.   NUCLEIC ACIDS RESEARCH

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA