Medically important fungi respond to azole drugs: an update

Multilaboratory Study of Epidemiological Cutoff Values for Detection of Resistance in Eight Candida Species to Fluconazole, Posaconazole, and Voriconazole

(2014) A. Espinel-Ingroff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

(2014) B. C. Monk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology and risk factors for invasive candidiasis

(2014) Nur Yapar   Therapeutics and Clinical Risk Management

Candida glabrata Drug:H+Antiporter CgQdr2 Confers Imidazole Drug Resistance, Being Activated by Transcription Factor CgPdr1

(2013) Catarina Costa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of Sterol Import under Aerobic and Anaerobic Conditions in Three Fungal Species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae

(2013) Martin Zavrel et al.   EUKARYOTIC CELL

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

(2013) Andrea Lohberger et al.   EUKARYOTIC CELL

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus 

(2013) Marcin G. Fraczek et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

TheCandida glabratasterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation

(2013) Minoru Nagi et al.   MOLECULAR MICROBIOLOGY

Candida albicanspathogenicity mechanisms

(2013) François L. Mayer et al.   Virulence

In Vitro Activity of Calcineurin and Heat Shock Protein 90 Inhibitors against Aspergillus fumigatus Azole- and Echinocandin-Resistant Strains

(2012) F. Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens

(2012) Andrew G. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of pH onIn VitroSusceptibility of Candida glabrata and Candida albicans to 11 Antifungal Agents and Implications for Clinical Use

(2012) Claire S. Danby et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Changes in Incidence and Antifungal Drug Resistance in Candidemia: Results From Population-Based Laboratory Surveillance in Atlanta and Baltimore, 2008-2011

(2012) A. A. Cleveland et al.   CLINICAL INFECTIOUS DISEASES

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Molecular Epidemiology of Aspergillus fumigatus Isolates Harboring the TR34/L98H Azole Resistance Mechanism

(2012) S. M. T. Camps et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Species Identification and Antifungal Susceptibility Testing of Candida Bloodstream Isolates from Population-Based Surveillance Studies in Two U.S. Cities from 2008 to 2011

(2012) S. R. Lockhart et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness inCandida albicans

(2012) Christoph Sasse et al.   MOLECULAR MICROBIOLOGY

Triazole Fungicides Can Induce Cross-Resistance to Medical Triazoles in Aspergillus fumigatus

(2012) Eveline Snelders et al.   PLoS One

Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

(2012) Simone M. T. Camps et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Sensitization of Candida albicans biofilms to various antifungal drugs by cyclosporine A

(2012) Ravikumar B Shinde et al.   Annals of Clinical Microbiology and Antimicrobials

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

(2011) Sabrina Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole Resistance of Aspergillus fumigatus Biofilms Is Partly Associated with Efflux Pump Activity

(2011) Ranjith Rajendran et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

(2011) Ann R. Holmes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin ResistanceIn Vivo

(2011) Keunsook K. Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Azole resistance inAspergillus fumigatus: a new challenge in the management of invasive aspergillosis?

(2011) Eveline Snelders et al.   Future Microbiology

Calcineurin Signaling and Membrane Lipid Homeostasis Regulates Iron Mediated MultiDrug Resistance Mechanisms in Candida albicans

(2011) Saif Hameed et al.   PLoS One

The Transcription Factor Ndt80 Does Not Contribute to Mrr1-, Tac1-, and Upc2-Mediated Fluconazole Resistance in Candida albicans

(2011) Christoph Sasse et al.   PLoS One

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-  Demethylase (CYP51) Isoenzymes A and B

(2010) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Calcineurin regulates innate antifungal immunity in neutrophils

(2010) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic Basis ofCandidaBiofilm Resistance Due to Drug‐Sequestering Matrix Glucan

(2010) Jeniel E. Nett et al.   JOURNAL OF INFECTIOUS DISEASES

Acquired antifungal drug resistance inAspergillus fumigatus:epidemiology and detection

(2010) Susan Julie Howard et al.   MEDICAL MYCOLOGY

Proteomics of drug resistance in Candida glabrata biofilms

(2010) C. Jayampath Seneviratne et al.   PROTEOMICS

Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi

(2010) Bryce E. Mansfield et al.   PLoS Pathogens

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

(2010) Edward Sionov et al.   PLoS Pathogens

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3- -D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint

(2009) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Analysis ofcis- andtrans-Acting Elements of theCandida albicans CDR2Promoter with a Novel Promoter Reporter System

(2009) Alix T. Coste et al.   EUKARYOTIC CELL

Ibuprofen reverts antifungal resistance onCandida albicansshowing overexpression of CDR genes

(2009) Elisabete Ricardo et al.   FEMS YEAST RESEARCH

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Formation of new chromosomes as a virulence mechanism in yeastCandida glabrata

(2009) Silvia Poláková et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

(2009) Sélène Ferrari et al.   PLoS Pathogens

Transcriptional Activation and Increased mRNA Stability Contribute to Overexpression of CDR1 in Azole-Resistant Candida albicans

(2008) R. Manoharlal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Establishing In Vitro-In Vivo Correlations for Aspergillus fumigatus: the Challenge of Azoles versus Echinocandins

(2008) M. C. Arendrup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Breakthrough Aspergillus fumigatus and Candida albicans Double Infection during Caspofungin Treatment: Laboratory Characteristics and Implication for Susceptibility Testing

(2008) M. C. Arendrup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomewide Location Analysis ofCandida albicansUpc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance

(2008) Sadri Znaidi et al.   EUKARYOTIC CELL

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

Functional analysis of Candida albicans GPI-anchored proteins: Roles in cell wall integrity and caspofungin sensitivity

(2008) Armêl Plaine et al.   FUNGAL GENETICS AND BIOLOGY

Rapid Detection of Triazole Antifungal Resistance in Aspergillus fumigatus

(2008) G. Garcia-Effron et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Synergistic activity of azoles with amiodarone against clinically resistant Candida albicans tested by chequerboard and time-kill methods

(2008) Q. Guo et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms

(2008) S. J. Hoot et al.   MICROBIOLOGY-SGM

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

The ATP-binding cassette transporter–encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata

(2008) Riccardo Torelli et al.   MOLECULAR MICROBIOLOGY

Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism

(2008) Eveline Snelders et al.   PLOS MEDICINE